DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pex1 and Pex1

DIOPT Version :9

Sequence 1:	NP_652016.1	Gene:	Pex1 / 45460	FlyBaseID:	FBgn0013563	Length:	1006	Species:	Drosophila melanogaster
Sequence 2:	NP_001102690.1	Gene:	Pex1 / 500006	RGDID:	1559939	Length:	1283	Species:	Rattus norvegicus

Alignment Length:	1080	Identity:	292/1080 - (27%)
Similarity:	509/1080 - (47%)	Gaps:	171/1080 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VVYRPIRSNFVLLPDQYYGVVSTYDTGCLSLQYNGRTHYASWAPQKGGGGIKDTEIGINARAAKE 72
            |.:...|..|:.||......:.......:.:..:.:..|.||...:......:....||.:..::
  Rat    19 VAFTNARDCFLHLPRHLVAQLHLLQNQAIEVTGDHQPTYLSWVEGRHFNDQSENVAEINRQVGQK 83

  Fly    73 IGLHENDLVKCALIADVLNLRSVHVTPVSSKDWEIIELSTEKISGSVLEQTRIVNSTQILIVWIN 137
            :||...|.|.....:.|::.:.|.|.|:|:.||||:||....:...:|:|.|||....|:.:|::
  Rat    84 LGLSSGDQVFLRPCSHVVSCQQVEVEPLSADDWEILELHAISLEEHLLDQIRIVFPKAIVPIWVD 148

  Fly   138 KSMQVALTVDRLKPHMNYGRIDHNTELVVAPNLYKGLTN-----GTSNGVIEENTKLSRSKTTAQ 197
            :...:.:.:..|.|...|||::.||:|::.|...:...:     |.:.|  :.:......|.|
  Rat   149 QQTYIFIQIVALMPTAPYGRLETNTKLLIQPKTRQAKESTFPKEGDARG--QAHNYGREQKGT-- 209

  Fly   198 VKDELTEKLTPLTHSSTVSNVKN-TIQRNKRQDH-------MERLKKDLRRESS-RSFEFRVIRG 253
            ||:..|::|...|.:..|||.:| .:..:..:..       |.....|.::||: .|.|....:.
  Rat   210 VKELQTKQLHKNTEAVPVSNGRNPEVPGDSVKPRWWAVLGSMFSFGPDNKQESAWGSLELGAFKN 274

  Fly   254 LWREQAQESDVF-----------------VNGKHL--------PEFFDLDLFYC--------MHT 285
            :..:......:|                 |..||.        .|:||::..:.        :|:
  Rat   275 MQSQTVPLDSIFRVCQVQPPSVHNTPANSVFHKHCTVHVFPWDQEYFDVEPSFTVVYGKLVKLHS 339

  Fly   286 -------------AADKDYYVRV----RTVEDDIEDDLPETI----------------------- 310
                         ..:|:..:..    :.:..|..::..||.
  Rat   340 PKQQQDKSKQGVLLPEKEKQLSQSPGHKRIGSDGSEEAAETCVLKVVWNGLEELKNATEFTKSLE 404

  Fly   311 ---HPSIELNANLMKLLGIKELERVV-LRPKTTVVNFVEKIELFANKKTHYKIMENAFKRFVIER 371
               |..:.:.|:|.|.|.| |:..|| :.|..|.......:.|...:.....:.|...|......
  Rat   405 PLHHGKVWIPADLRKRLNI-EMHAVVRITPLETTPVIPRALRLQPAENLPRDVSEEEVKAVFSSW 468

  Fly   372 TQHK-----PMLFNQEEVVRLEDDLLVTVGILPEHFRYCVVDAQFLKESKIYAADLVRPVGEIIK 431
            .|..     |::.:::|.::||    :..|:  :.|...:|.:|..::.:.....::.|:  :::
  Rat   469 LQESATTMFPLIISKQECIKLE----IKDGL--KEFSLSIVHSQEKEKEQGRTVFVLSPI--LLQ 525

  Fly   432 EETPPTSPLSVQDLIQ--LPEYDKIVDQVVQELRM-------NLCLSADNSV------------- 474
            :       :|||.|::  :.|:.:.:|.::..|.:       :|.:||...:
  Rat   526 K-------ISVQVLLEPMIGEHSEEIDILLPSLTLSSLGGVSSLSVSAMEHITHSLLGRPLSRQL 583

  Fly   475 ------MRQCNVLLAGASGTGKTVLVERILDQLSRKPDYCHFEFFHGSRSKGRKTESIQKDLRNI 533
                  :|...:|:.|..|:||:.|.:.|..:.....| .|.|.......:|::.|||||.|...
  Rat   584 MALVAGLRNGALLITGGKGSGKSTLAKAICKEAHDALD-AHVEMVDCKALRGKRLESIQKALEVA 647

  Fly   534 FTSCLQHAPAIVVLENLDVLAHAAGEQSSQDGEY------YNRMADTVYQLIVQYTT-NNAIAVI 591
            |:......|::::|::||::   ||..|:.:.|:      ..|:|..:..:|.::.: .:.:|:|
  Rat   648 FSEAAWRQPSVILLDDLDLI---AGLPSTPEHEHSPEAVQSQRLAHALNNMIKEFVSMGSLVALI 709

  Fly   592 ATVNELQTLNKRLSSPRGRHVFQTVARLPNLERADR-----EIILRELCSHINVAKDLDLVKFSN 651
            ||.....:|:..|.|.:|.|.||.:..:...::..|     .::..:|...|:.:.||||...:.
  Rat   710 ATSQLQHSLHPSLVSAQGVHTFQCIQHIQPPDQEQRCEILHSVVKNKLGCDISKSPDLDLKCIAK 774

  Fly   652 LTEGYRKCDLVQFVERAIFYAYRISKTQPLLTNDQLIESLEHTNS---YCLQG-IQSNQRTGNDA 712
            .||.:...|....|:|||..:  :|:.|     :...|.|..|.:   ..|:| :.::.|..|..
  Rat   775 ETEAFVARDFTVLVDRAIHSS--LSRQQ-----NPTREGLTLTTADFQKALRGFLPASLRNVNLH 832

  Fly   713 DANEMRVEELPGLESVVGVLEEVLMWPSRYPTIFNASPLRNQAGVLLYGPPGTGKTYLVSQLATS 777
            ...::..:::.||..|..:|.:.:..|::||.:|...|:|.:.|:|||||||||||.|...:|..
  Rat   833 KPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVVARE 897

  Fly   778 WNLRIISVKGPELLAKYIGQSEENVRNLFNRARSARPCVLFFDEFDSLAPKRGHDSTGVTDRVVN 842
            ..:..||::|||||:||||.||:.||::|.||::|:||:||||||:|:||:||||:|||||||||
  Rat   898 SGMNFISIQGPELLSKYIGASEQAVRDVFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDRVVN 962

  Fly   843 QLLTELDGVEGLQGVTVIAATSRPELLDPALLRSGRIDRLVECPLPDAPARVRIFEALSSTLSLD 907
            ||||:||||||||||.|:||||||:|:||||||.||:|:.|.||.||..:|:.|...||.:|.|.
  Rat   963 QLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILTVLSKSLPLA 1027

  Fly   908 ECVDFDWFAGKTANYTGADIQSILTSANMAAVKEALAQFG 947
            :.||....|..|.::||||::::|.:|.:.|::..|...|
  Rat  1028 DDVDLQHVASVTESFTGADLKALLYNAQLEALQGRLLPGG 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex1	NP_652016.1	PEX-1N	93..168	CDD:286361	25/74 (34%)
		SpoVK	479..974	CDD:223540	185/485 (38%)
		P-loop_NTPase	480..604	CDD:304359	34/130 (26%)
		AAA	757..887	CDD:278434	89/129 (69%)
Pex1	NP_001102690.1	PEX-2N	19..98	CDD:286362	14/78 (18%)
		PEX-1N	104..179	CDD:286361	25/74 (34%)
		AAA	591..741	CDD:214640	37/159 (23%)
		AAA	595..724	CDD:278434	34/138 (25%)
		AAA	877..1009	CDD:214640	35/82 (43%)
		AAA	877..1006	CDD:278434	35/82 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353569
Domainoid	1	1.000	191	1.000	Domainoid score	I3151
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	388	1.000	Inparanoid score	I1945
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171861at2759
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	1	1.000	-	-		oto98022
orthoMCL	1	0.900	-	-		OOG6_103335
Panther	1	1.100	-	-	LDO	PTHR23077
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3465
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760