Protein Alignment Pex1 and NVL

DIOPT Version :10

• Sequence 1: NP_652016.1
• Gene: Pex1 / 45460
• FlyBaseID: FBgn0013563
• Length: 1006
• Species: Drosophila melanogaster
• Sequence 2: XP_016856867.1
• Gene: NVL / 4931
• HGNCID: 8070
• Length: 917
• Species: Homo sapiens
• Alignment Length: 1017
• Identity: 248/1017 - (24%)
• Similarity: 419/1017 - (41%)
• Gaps: 226/1017 - (22%)

  Fly    82 KCALIADV----LNLRSVHVTPVSSKDWEIIELSTEKISGSVLEQTRIVNSTQILIVWINKSMQV 142
            ||....|:    .:|:.|:......:......:..||:...:..:..:.|.|:
Human    25 KCGKYVDIGVLASDLQRVYSIDYGRRKRNAFRIQVEKVFSIISSEKELKNLTE------------ 77

  Fly   143 ALTVDRLKPHMNYGRIDHNTELVVAPNLYKGLTNGTSNGVIEENTKLSRSKTTAQVKDELTEKLT 207
             |..:.|......|..|::..|     .:.|.            :.|::|..||.:..:....|.
Human    78 -LEDEHLAKRARQGEEDNDVSL-----CHPGF------------SALAQSWLTAVLTSQAQAILP 124

  Fly   208 PLTHSSTVSNVKNTIQRNKRQDHMERLKKDLRRESSRSFEFRVIRGLWREQAQESDVFVNGKHLP 272
            |..|..|.|...:.   :..:|:.:....:....|        :..|:|:...:|     ..:.|
Human   125 PQPHRYTESYSDDD---SSMEDYPDPQSANHMNSS--------LLSLYRKGNPDS-----VSNTP 173

  Fly   273 EFFDLDLFYCMHTAADKDYYVRVRTVEDDIEDD--LPETIHPSIELNANLMKLLGIKELERVVLR 335
            |....:........:.|...:.::|...|.|..  :.:|  ||::.::..:.|...|...:   :
Human   174 EMEQRETTSSTPRISSKTGSIPLKTPAKDSEGGWFIDKT--PSVKKDSFFLDLSCEKSNPK---K 233

  Fly   336 PKTTVVNFVEKIELFANKKTHYKIMENAFKRFVIERTQHKPMLFNQEEVVRLEDDLLVTVGILPE 400
            |.|.:.:..:...|.::.|...|:.....||             .:|::..::.:
Human   234 PITEIQDSKDSSLLESDMKRKGKLKNKGSKR-------------KKEDLQEVDGE---------- 275

  Fly   401 HFRYCVVDAQFLKESKIYAADLVRPVGEIIKEETPPTSPLSVQDLIQLPEYDKIVDQVVQELRMN 465
                  ::|...|::|  |..|...:.. :|.|....:.::::::.::     ::.....|:..:
Human   276 ------IEAVLQKKAK--ARGLEFQISN-VKFEDVGGNDMTLKEVCKM-----LIHMRHPEVYHH 326

  Fly   466 LCLSADNSVMRQCNVLLAGASGTGKTVLVERI--LDQLSRKPDYCHFEFFHGSRS---------- 518
            |      .|:....|||.|..|.|||:|...|  .:.......:|.|: |.||..
Human   327 L------GVVPPRGVLLHGPPGCGKTLLAHAIAGAECSGMITAHCSFD-FSGSNDPPASASQELD 384

  Fly   519 ------------KGRKTESIQKDLRNIFTSCLQHAPAIVVLENLDVLAHAAGEQSSQDGEYYNRM 571
                        .|...||.|| ||.:|...:.:||.|:.::.:|.:. ...|.:|:|.|
Human   385 LPILKVAAPEIVSGVSGESEQK-LRELFEQAVSNAPCIIFIDEIDAIT-PKREVASKDME----- 442

  Fly   572 ADTVYQLIVQYTT-----NNAIA-----VIATVNELQTLNKRLSSPRGRHVFQTVARLPNLERAD 626
                .:::.|..|     ||..|     ||...|...:|:..|.. .||...:....:|  :.|.
Human   443 ----RRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRR-AGRFDREICLGIP--DEAS 500

  Fly   627 REIILRELCSHINVAKDLDLVKFSNLTEGYRKCDLVQFVERAIFYAYR--ISKTQPLLTNDQLIE 689
            ||.||:.||..:.:.:..|....::||.|:...||:.....|...|..  :.|.|.....:..:|
Human   501 RERILQTLCRKLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKLQEQQKKNPEME 565

  Fly   690 SLEHTNSYCLQGIQSNQRTGND----------------ADANEMRVEELPG-----------LES 727
            .|..      :|:| .:|.|.:                .|.:.:..|::.|           |.|
Human   566 DLPS------KGVQ-EERLGTEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALSS 623

  Fly   728 V-------------------VGVLEEV-------LMWPSRYPTIFNASPLRNQAGVLLYGPPGTG 766
            |                   :|.||::       ::.|.|.|..|.|..|...|||||.||||.|
Human   624 VQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCG 688

  Fly   767 KTYLVSQLATSWNLRIISVKGPELLAKYIGQSEENVRNLFNRARSARPCVLFFDEFDSLAPKRGH 831
            ||.|...:|....|..|||||||||..|:|:||..||.:|.||:::.|||:||||.|:|.|:|..
Human   689 KTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSD 753

  Fly   832 DSTGVTDRVVNQLLTELDGVEGLQGVTVIAATSRPELLDPALLRSGRIDRLVECPLPDAPARVRI 896
            ..||.:.|||||||||:||:|..|.|.::|||:||:::|||:||.||:|:.:...||....|:.|
Human   754 RETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRLAI 818

  Fly   897 FEALSSTLS---LDECVDFDWFAG--KTANYTGADIQSILTSANMAAVKEALA--QFGHEKLAKK 954
            .:.::...:   ||..|:.:..||  :...|||||:.:::..|::.|:::.:|  :.|:||...|
Human   819 LKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREASICALRQEMARQKSGNEKGELK 883

  Fly   955 ISLKQKHLIESFQTTRPSLSASDVAKYHRTYARFTNKEKTSR 996
            :|  .||..|:|:..|.|:|..|...|.|.      :|..||
Human   884 VS--HKHFEEAFKKVRSSISKKDQIMYERL------QESLSR 917

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pex1	NP_652016.1	PEX-1N	93..168	CDD:462729	10/74 (14%)
		CDC48	365..983	CDD:273521	199/713 (28%)
		RecA-like_PEX1_r2	728..885	CDD:410934	83/182 (46%)
NVL	XP_016856867.1	Nucleolin_bd	2..72	CDD:465247	7/46 (15%)
		CDC48	<277..917	CDD:273521	198/683 (29%)