Protein Alignment Pex1 and DRC11L

DIOPT Version :10

• Sequence 1: NP_652016.1
• Gene: Pex1 / 45460
• FlyBaseID: FBgn0013563
• Length: 1006
• Species: Drosophila melanogaster
• Sequence 2: NP_001291348.1
• Gene: DRC11L / 392843
• HGNCID: 22831
• Length: 818
• Species: Homo sapiens
• Alignment Length: 990
• Identity: 190/990 - (19%)
• Similarity: 313/990 - (31%)
• Gaps: 376/990 - (37%)

  Fly   157 RIDHNTELVVAP---NLYKGLTNGTSNGVIE-----------ENTKLSR---------------- 191
            |.|...:.:|.|   .|.:.|.:|.:..|:|           ||..|.|
Human    56 RFDTVYDQMVQPQKRRLLRRLLDGVAGRVLELKDELVRADLCENHCLDRVLQDFKLTPADLEVPI 120

  Fly   192 -------SKTTAQ----VKDELTEKLTPLTHSSTVSNVKNT-----IQRNKRQDHMERLKKDLRR 240
                   ..||.:    :..|:..:|.|::...:.:.:..|     :|:.:|. ...||:....|
Human   121 PKYFLLEQSTTVRERGLILAEILSRLEPVSSQKSFTGMHRTEAIILVQKAERA-RQGRLRATFMR 184

  Fly   241 ESSRSFEFRVIRGLWREQAQESDVFVNGKHLPEFFDLDLFYCMHTAAD------KDYYVRVRTVE 299
            |         ||   |::.|:..:..:|.|.         :....||.      |.|..|.||.:
Human   185 E---------IR---RDEEQDGRIREDGWHK---------FSQGQAAVTIQKVWKGYLQRKRTQQ 228

  Fly   300 DDIEDDLPETIHPSIELNANLMKLLGIKELERVVLRPKTTVVNFVEKIELFANKKTHYKIMENAF 364
            |                        ...|:|.:.:.|.             .|:..|..|:.
Human   229 D------------------------RRMEMEFIGMLPS-------------PNQVEHLSIIS--- 253

  Fly   365 KRFVIERTQHKPMLFNQEE----VVRLEDDLLVTVGILPEHFRYCVVDAQFLKESKIYAADLVRP 425
            :..::|..|....:..:||    :|:..|.|:.|.|                       .|:...
Human   254 QPCLVEDVQRLRQMEKEEEFRAAMVKAHDSLVETEG-----------------------PDMKEK 295

  Fly   426 VGEIIKEETPPTSPLSVQDLI-QLPEY-------------DKIVDQVVQELRMNLCLSADNSVMR 476
            :.|.|::..     :...||. :.|:|             ||..:||..||.|.:
Human   296 MKEQIRQWF-----IECHDLTGRFPDYPDASSGGSYSIFADKTPEQVRMELEMQM---------- 345

  Fly   477 QCNVLLAGASGTGKTVLVERILDQLSRKPDYCHFEFFHGSRSKGRKTESIQKDLRNIFTSCLQHA 541
                                   |.:||.:.      ..|:.||:..:..:|
Human   346 -----------------------QENRKKEQ------EKSKEKGKDEKEKKK------------- 368

  Fly   542 PAIVVLENLDVLAHAAGEQSSQDGEYYNRMADTVYQLIVQYTTNNAIAVIATVNE--LQTLNKRL 604
                           ..|:.::.||     .|.|.|::    .:..|.:|...:|  |.|...|.
Human   369 ---------------GKEEKAKKGE-----VDAVLQVL----PSKCIPMICAGHEEYLNTWKNRC 409

  Fly   605 SS--PRGRHVFQTVARLPNLERADREIILRELCSHINVAKDLDLVKFSNLTEGYRKCDLVQFVER 667
            .|  |...:..:|:          ||...:|:...|.:..| :|::     :..||..|.  |::
Human   410 ESIHPSQNYDSETL----------REEKRKEVELEIRIQVD-ELMR-----QELRKLRLA--VDK 456

  Fly   668 AIFYAYRISKTQP----------LLTNDQLIESLEHTNSYCLQGIQSNQRTGNDADANEMRVEEL 722
            ......|..|..|          .||:|:.:|||  .....:.|:              :|..|.
Human   457 EEERPLRAPKKTPGKKTGKKKEKDLTSDRSVESL--YEELVISGL--------------LRKSES 505

  Fly   723 PGLESVVG---------VLEEVLMWPSRY----------------PTIFNASPLRNQAGVLLYGP 762
            ..|:..:|         .|.:.|..||.:                |.|...:||..  .:||.||
Human   506 VALKDYIGDFLYLGSTLSLVKKLPMPSLFDIRQNVALYAVLRLGSPDIHIMAPLIR--SILLVGP 568

  Fly   763 PGTGKTYLVSQLATSWNLRIISVKGPELLAKYIGQ--SEENVRNLFNRARSARPCVLFFDEFDSL 825
            .|.||..||..:.|.....:..:....||.||.|:  ::..|..:|..||..:|.|::...
Human   569 SGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRNGAQMMVHIVFKVARLLQPSVIWIGN---- 629

  Fly   826 APKRGHDSTGVTDRVVNQLLTELDGVEGLQGVT------VIAATSRPELLD-PALLRSGRIDRLV 883
            |.|..:..|...|:.::....:.|..:.|:.:|      :|..||||:|.: ..|.|.  .:|::
Human   630 AEKNFYKKTPKEDKEMDPKRIKKDLTKALRLLTPGDRVMLIGTTSRPQLAEMRGLCRV--YERIL 692

  Fly   884 ECPLPDAPARV----RIFEA--LSSTLSLDECVDFDWFAGKTANYTGADIQSILT-------SAN 935
            ..|.||..:|.    |:.||  :..|..||.........|.|..:....|||:|:       |..
Human   693 FMPRPDYASRYVLWKRMIEARGIQPTQHLDISALAKVSDGYTPGHILQAIQSVLSERRFLQLSKR 757

  Fly   936 MAAVKEALAQ-------FGHEK-----------LAKKISLKQKHLIESFQTTRPSLSASDVAKYH 982
            .....|.|.|       :..|:           |.||   ..||.::..:.....|
Human   758 PLVASEFLGQLVKLDPVYREEEESLKDWYFKTPLGKK---SMKHRMDQLEAEEAKL--------- 810

  Fly   983 RTYARFTNKEKTSRE 997
                   :|||..|:
Human   811 -------DKEKKKRK 818

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pex1	NP_652016.1	PEX-1N	93..168	CDD:462729	3/10 (30%)
		CDC48	365..983	CDD:273521	141/714 (20%)
		RecA-like_PEX1_r2	728..885	CDD:410934	46/190 (24%)
DRC11L	NP_001291348.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	344..377		8/99 (8%)
		SpoVK	411..744	CDD:440232	85/374 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	458..482		3/23 (13%)
		P-loop containing Nucleoside Triphosphate Hydrolases	535..694	CDD:476819	41/166 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	795..818		6/38 (16%)