DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pex1 and smid

DIOPT Version :9

Sequence 1:	NP_652016.1	Gene:	Pex1 / 45460	FlyBaseID:	FBgn0013563	Length:	1006	Species:	Drosophila melanogaster
Sequence 2:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster

Alignment Length:	1016	Identity:	232/1016 - (22%)
Similarity:	392/1016 - (38%)	Gaps:	315/1016 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 EKLTPLTHSSTVS-NVKNTIQRNKRQDHMERLKKDLRRE--------SSRSFEFRVIRGLWREQA 259
            :|..||.|...:: .||..::.:..:.:::  .|.:.||        |.|.|      |.:|:..
  Fly     2 KKAKPLLHDHLITIRVKKYLEEHIGETYLD--VKQMTRELMQKYPEYSRRKF------GPFRQLV 58

  Fly   260 QESDVFVNGKHLPEFFDLDLFYCMHTAADKDYYVRVRTVEDDI--EDDLPETIHPSIELNANLMK 322
            .::...::     |.::||               :|.:.|:|.  ||..|.   |:..:..|:|.
  Fly    59 HQAFSIIS-----ESYNLD---------------KVSSSEEDCVSEDSEPP---PTNSVMNNMMN 100

  Fly   323 LLGIKELERVVLRPKTTVVNFV--EKIELFANKKTHY---------------KIMENAFKRFVIE 370
            .|..:..:.:..:|.:..::..  ::.|..:|.||..               .:..:|.||.:
  Fly   101 SLYSQPRKPLAPKPISEPIDISSGDENEDDSNTKTTNGDGVAAAAAPPPPTPAVQGSALKRLM-- 163

  Fly   371 RTQHKPMLFNQEEVVRLEDDLLVTVGILPEHFRYCVVDAQFLKESKIY--AADLVRPVGEII--- 430
                       |||              ||   ..|...:..|.:.|:  :::.::.:.:::
  Fly   164 -----------EEV--------------PE---IAVAAKKVAKPNTIHVSSSEAIQKLHQVVGNR 200

  Fly   431 ----KEETPPTS------PLSVQDLIQLPEYDKI---------------------VDQVVQEL-R 463
                .|:..|.|      |...|.|.|....|::                     :|..::|| .
  Fly   201 AKNLSEDAVPRSKDHRNVPGLYQQLHQNQSRDRLRKFKRDLEVQHPTESFRDIGGMDSTLKELCE 265

  Fly   464 MNLCLSADN-----SVMRQCNVLLAGASGTGKTVLVERILDQLSRKP--DYCHFEFFHGSRSKGR 521
            |.:.:.:..     .::....:||.|..|.|||.|...|..|| :.|  :....|...|  ..|.
  Fly   266 MLIHIKSPEFYFQLGLLPSRGLLLHGPPGCGKTFLARAISGQL-KMPLMEIPATELIGG--ISGE 327

  Fly   522 KTESIQKDLRNIFTSCLQHAPAIVVLENLDVLAHAAGEQSSQDGEYYNRMADTVYQLIVQYTTN- 585
            ..|.|    |.:|...:.::|.::.::.:|.:. ...:.:|:|.|  .|:...:...:.....|
  Fly   328 SEERI----REVFDQAIGYSPCVLFIDEIDAIG-GNRQWASKDME--RRIVSQLISSLDNLKANE 385

  Fly   586 --NAIAVIATVNELQTLN---KRLSSPRGRHVFQTVARLPNLERADREIILRELCSHINVAKDLD 645
              .::.|||.......|:   :|:    ||...:....:|:  |.:|..|||..|..::|...|:
  Fly   386 FGQSVVVIAATTRPDVLDPGLRRI----GRFDHEIAIHIPS--RKERREILRIQCEGLSVDPKLN 444

  Fly   646 LVKFSNLTEGYRKCDLVQFVERAIFYAYR---ISKTQPL------------LTNDQLIESLEHTN 695
            ..|.:.||.||...||:..|.||...|.:   :.|.:.|            |.:|:..|....|.
  Fly   445 YDKIAELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVTLDDDEPSEDAGETP 509

  Fly   696 SYCLQGIQSNQRTGNDADANEMRVE-------------ELPGLESV------------------- 728
            ....:|    :.|..||:| |.:|:             :.|.:|:.
  Fly   510 VPDSKG----EETAKDAEA-EQKVDGDKETSAKDKSEGDSPNIETPKKATNGNSSIKSPQKTPKK 569

  Fly   729 ----------------------------------------------------------------- 728

  Fly   570 SAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFADPNFCLTL 634

  Fly   729 -----------------------------VGVLEEV-------LMWPSRYPTIFNASPLRNQAGV 757
                                         :|.||::       ::.|.:||.:.....|...:||
  Fly   635 IDFVDAIKVMQPSAKREGFITVPDTTWDDIGALEKIREELKLAVLAPVKYPEMLERLGLTAPSGV 699

  Fly   758 LLYGPPGTGKTYLVSQLATSWNLRIISVKGPELLAKYIGQSEENVRNLFNRARSARPCVLFFDEF 822
            ||.||||.|||.|...:|....:..||||||||:..|:|:||..||..|.|||::.|||:|||||
  Fly   700 LLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRACFQRARNSAPCVIFFDEF 764

  Fly   823 DSLAPKR--GHDSTGVTDRVVNQLLTELDGVEGLQGVTVIAATSRPELLDPALLRSGRIDRLVEC 885
            |||.|||  |.|......|:|||||||:||||..:||.::|||:||:::|||:||.||:|.::..
  Fly   765 DSLCPKRSDGGDGNNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILRPGRLDTILYV 829

  Fly   886 PLPDAPARVRIFEALSSTLS---LDECVDFDWFAGKTANYTGADIQSILTSANMAAVKEALAQFG 947
            ..|:...|..|.:|.:....   |.:.||.|..|.:|..|||||:..::..|:|.:::::|.. |
  Fly   830 GFPEQSERTEILKATTKNGKRPVLADDVDLDEIAAQTEGYTGADLAGLVKQASMFSLRQSLNN-G 893

  Fly   948 HEKLAKKISLKQKHLIESFQTTRPSLSASDVAKYHRTYARF 988
            ...| ..:.::.:|..|:.|..|||::..|...|.:...::
  Fly   894 DTNL-DDLCVRSQHFQEALQQLRPSVNEQDRKIYDKLRLKY 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex1	NP_652016.1	PEX-1N	93..168	CDD:286361
		SpoVK	479..974	CDD:223540	175/655 (27%)
		P-loop_NTPase	480..604	CDD:304359	30/131 (23%)
		AAA	757..887	CDD:278434	73/131 (56%)
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330	15/81 (19%)
		SpoVK	271..919	CDD:223540	175/670 (26%)
		AAA	287..418	CDD:278434	33/144 (23%)
		P-loop_NTPase	679..>716	CDD:304359	16/36 (44%)
		AAA	699..830	CDD:278434	73/130 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445201
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23077
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.840