Protein Alignment Pex1 and Afg2a

DIOPT Version :10

• Sequence 1: NP_652016.1
• Gene: Pex1 / 45460
• FlyBaseID: FBgn0013563
• Length: 1006
• Species: Drosophila melanogaster
• Sequence 2: NP_001402011.1
• Gene: Afg2a / 361935
• RGDID: 1310478
• Length: 893
• Species: Rattus norvegicus
• Alignment Length: 993
• Identity: 245/993 - (24%)
• Similarity: 408/993 - (41%)
• Gaps: 235/993 - (23%)

  Fly    46 YASWAPQKGGGGIKDTEIGINARAAKEIGLHENDLVKC-ALIADVLNLRSVHVTPVSSKDWEIIE 109
            |.:| |..|..|.|   :|::..|.|.:|:...:.::. .|:..||..:.:.:. :|.||.||.|
  Rat    97 YTAW-PVAGFPGGK---VGLSEMAQKNVGVKAGETIRVQPLLGAVLQAQEMDLA-LSDKDKEINE 156

  Fly   110 LSTEKISGSVLEQT--RIVNSTQILIVWINKSMQVALTVDRLKPHMNYGRIDHNTELVVAPNLYK 172
               |:::|.:|.:.  :||.....|....                  |||:.....|.|     |
  Rat   157 ---EELTGCILRKLDGKIVLPGNFLYCTF------------------YGRLCKLQVLQV-----K 195

  Fly   173 GLTNGTSNGVIEENTKLSRSKTTAQVKDELTEKLTPLTHSSTVSNVKNTIQRNKRQDHMERLKKD 237
            | |:||:.|                         .|.:.|.|
  Rat   196 G-TDGTTLG-------------------------KPQSSSGT----------------------- 211

  Fly   238 LRRESSRSFEFRVIRGLWREQA--QESDVFVNGKHLPEFFDLDLFYCMHTAADKD--YYVRVRTV 298
                        .:.|:..||:  :.|||.::.    :...|||......|:...  ..:..||:
  Rat   212 ------------DVHGMASEQSSMESSDVDISF----QLSQLDLKEPQSPASQSTPCKPINDRTM 260

  Fly   299 EDDIEDDLPETIHPSIELNANLMKLLGIK--------------ELERVVLRPKTTVVNFVEKIEL 349
            ....|..|..|..|.......|.::.|:|              ..|:::........|
  Rat   261 NKAGEVLLDVTQSPRDGSGLGLEEITGLKCSFDSSKEGNTQPISEEKLLKSTSAGAKN------- 318

  Fly   350 FANKKTHYKIMENAFKRFVIERTQHKPMLFNQEEVVRLEDDLLVTVGILPEHFRYCVVDAQFLKE 414
              |..|.|.|....       |...:.:..|.:|                       .|:||
  Rat   319 --NTDTFYFISSTT-------RINLRKICTNSKE-----------------------QDSQF--- 348

  Fly   415 SKIYAADLVRPVGEIIKEETPPTSPLSVQDLIQLPEYDKIVDQVVQELRMNLCLSADNSVMRQCN 479
             |: ..|::..:...:|         :::::|:||     :.|  .||..:..:.|..      .
  Rat   349 -KV-TYDMIGGLNSQLK---------AIREIIELP-----LKQ--PELFKSYGIPAPR------G 389

  Fly   480 VLLAGASGTGKTVLVERILDQLSRKPDYCHFEFFHGSRSKGRKTESIQKDLRNIFTSCLQHAPAI 544
            :||.|..|||||::...:.:::.     .:....:|.....:.....:..||.||.......|:|
  Rat   390 LLLYGPPGTGKTMIARAVANEVG-----AYVSVINGPEIISKFYGETEARLRQIFAEATLRHPSI 449

  Fly   545 VVLENLDVLA-HAAGEQSSQDGEYYNRMADTVYQL---IVQYTTNNAIAVIATVNELQTLNKRLS 605
            :.::.||.|. ...|.||    |...|:..::..|   |....:...:.|:...|..|.|:..|.
  Rat   450 IFIDELDALCPKREGAQS----EVEKRVVASLLTLMDGIGSEGSEGRVLVLGATNRPQALDAALR 510

  Fly   606 SPRGRHVFQTVARLPNLERADREIILRELCSHI-NVAKDLDLVKFSNLTEGYRKCDLVQFVERAI 669
            .| ||...:....:||.:  ||..||::|...: ::....:|::.:|...||...||......|.
  Rat   511 RP-GRFDKEIEIGIPNAQ--DRLDILQKLLRRVPHLLTKAELLRLANNAHGYVGADLKALCNEAG 572

  Fly   670 FYAY-RISKTQPLLTNDQLIESLEHTNSYCLQGIQSNQRTGNDADANEMRV----------EELP 723
            .||. |:.:.||.|.:.::...::.|.:..|||:       ||...:.||.          .::.
  Rat   573 LYALRRVLRKQPNLPDSKVAGMVKITLNDFLQGM-------NDIRPSAMREVAIDVPNVSWSDIG 630

  Fly   724 GLESVVGVLEEVLMWPSRYPTIFNASPLRNQAGVLLYGPPGTGKTYLVSQLATSWNLRIISVKGP 788
            |||::...|::.:.||.::|..|:...::...|||||||||..||.:...||....|..:::|||
  Rat   631 GLENIKLKLKQAVEWPLKHPKSFSRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGP 695

  Fly   789 ELLAKYIGQSEENVRNLFNRARSARPCVLFFDEFDSLAPKRGHDS--TGVTDRVVNQLLTELDGV 851
            ||:.||:|:||..||.:|.:||:..|.::||||.|:||.:||..|  ..|.|||:.|||||:||:
  Rat   696 ELMNKYVGESERAVREVFRKARAVAPSIIFFDELDALAVERGSSSGAGNVADRVLAQLLTEMDGI 760

  Fly   852 EGLQGVTVIAATSRPELLDPALLRSGRIDRLVECPLPDAPARVRIFEALSSTLSLDECVDFDWFA 916
            |.|:.|||:|||:||:.:|.||:|.|||||::..|||||..|..|......::.:...||.|...
  Rat   761 EQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREILNLQFHSMPISNEVDLDELV 825

  Fly   917 GKTANYTGADIQSILTSANMAAVKEALAQFGHEKLAKKISLKQKHLIESFQTTRPSLSASDVAKY 981
            .:|..|:||:|.::...|.:.|::|.:         |...:.::|..::.....|.:..| :.::
  Rat   826 LQTDTYSGAEIIAVCKEAALLALEENI---------KADCIMKRHFTQALSIVTPRIPES-LRRF 880

  Fly   982 HRTYARFTNKEKTSREFV 999
            :..|     :||:....|
  Rat   881 YEDY-----QEKSGLHMV 893

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pex1	NP_652016.1	PEX-1N	93..168	CDD:462729	17/76 (22%)
		CDC48	365..983	CDD:273521	177/635 (28%)
		RecA-like_PEX1_r2	728..885	CDD:410934	75/158 (47%)
Afg2a	NP_001402011.1	CDC48_N	64..132	CDD:451359	10/38 (26%)
		CDC48	<323..889	CDD:273521	182/656 (28%)