Protein Alignment Pex1 and cdc48

DIOPT Version :10

• Sequence 1: NP_652016.1
• Gene: Pex1 / 45460
• FlyBaseID: FBgn0013563
• Length: 1006
• Species: Drosophila melanogaster
• Sequence 2: NP_593287.3
• Gene: cdc48 / 2542744
• PomBaseID: SPAC1565.08
• Length: 809
• Species: Schizosaccharomyces pombe
• Alignment Length: 884
• Identity: 223/884 - (25%)
• Similarity: 369/884 - (41%)
• Gaps: 184/884 - (20%)

  Fly   202 LTEKLTPLTHSSTVSNVKNT---------IQRNKRQ------DHMERLKKDLRRESSRSFE-FRV 250
            :|:|...:.|....:..|:|         |.|.||:      |........:...||.:.| .::
pombe     1 MTDKKPEVEHLQGENPPKDTYSAEDTATAILRKKRKPNSLVVDDATNDDNSVITLSSNTMETLQL 65

  Fly   251 IRGLWREQAQESDVFVNGKHLPEFFDLDLFYCMHTAADKDYYVRVRTVEDDIEDDLPETIHPSIE 315
            .||        ..|.|.||.                 .||..:.|.| ::::||
pombe    66 FRG--------DTVVVKGKR-----------------RKDTVLIVLT-DEEMED----------- 93

  Fly   316 LNANLMKLLGIKELERVV---LRPK----TTV-----VNFVEKIELFANKKTHYKIMENAFKRFV 368
                     |:..:.|||   ||.:    .|:     :.:.|:|.:.....|...:..:.|..::
pombe    94 ---------GVARINRVVRNNLRVRLGDIVTINPCPDIKYAERISVLPLADTVEGLTGSLFDVYL 149

  Fly   369 IERTQHKPMLFNQEEVVRLEDDLLVTVGILPEHFRYCVVDAQFLKESKIYAAD-LVRPVGEIIKE 432
                  ||........:| :.||.|..|.: ....:.|||.. ..|..|.:.| ::...||.|..
pombe   150 ------KPYFVEAYRPIR-KGDLFVVRGSM-RQVEFKVVDVA-PDEFGIVSQDTIIHWEGEPINR 205

  Fly   433 ETPPTS---------------PLSVQDLIQLP-EYDKIVDQVVQELRMNLCLSADNSVMRQCNVL 481
            |...:|               ...:::|::|| .:.::...:              .:.....:|
pombe   206 EDEESSLAEVGYDDIGGCRRQMAQIRELVELPLRHPQLFKSI--------------GIKPPRGIL 256

  Fly   482 LAGASGTGKTVLVERILDQLSRKPDYCHFEFFHGSRSKGRKTESIQKDLRNIFTSCLQHAPAIVV 546
            :.|..|||||::...:.::..     ..|...:|.....:.....:.:||..|....:::|||:.
pombe   257 MYGPPGTGKTLMARAVANETG-----AFFFLINGPEIMSKMAGESESNLRKAFEEAEKNSPAIIF 316

  Fly   547 LENLDVLAHAAGEQSSQDGEYYNRMADTVYQLIVQYTTNNAIAVIATVNELQTLNKRLSSPRGRH 611
            ::.:|.:   |.::...:||...|:...:..|:......:.:.|:|..|...:::..|.
pombe   317 IDEIDSI---APKREKTNGEVERRVVSQLLTLMDGMKARSNVVVMAATNRPNSIDPALR------ 372

  Fly   612 VFQTVARLPNLERADREI------------ILRELCSHINVAKDLDLVKFSNLTEGYRKCDLVQF 664
                     ...|.|||:            |||....::.:|.|:||.:.:..|.||...||...
pombe   373 ---------RFGRFDREVDVGIPDPTGRLEILRIHTKNMKLADDVDLEQIAAETHGYVGSDLASL 428

  Fly   665 VERAIFYAYRISKTQPLLTNDQL----IESLEHTNS---YCLQGIQSNQRTGNDADANEMRVEEL 722
            ...|.....|.......|..|::    ::||..|..   :.|.....:.......:...:|.|::
pombe   429 CSEAAMQQIREKMDMIDLDEDEIDAEVLDSLGVTMDNFRFALGSSNPSALRETVVEVPNVRWEDI 493

  Fly   723 PGLESVVGVLEEVLMWPSRYPTIFNASPLRNQAGVLLYGPPGTGKTYLVSQLATSWNLRIISVKG 787
            .|||.|...|.|.:..|..|...|....:....|||.:||||||||.|...:|...:...|||||
pombe   494 GGLEEVKRELRETVQMPVMYAEKFLRFGVTPSKGVLFFGPPGTGKTLLAKAIANECSANFISVKG 558

  Fly   788 PELLAKYIGQSEENVRNLFNRARSARPCVLFFDEFDSLAPKRGHDS--TGVTDRVVNQLLTELDG 850
            ||||:.:.|:||.|||::|::||:|.|||:|.||.||:|..||..:  :|..||||||||||:||
pombe   559 PELLSMWFGESESNVRDIFDKARAAAPCVVFLDELDSIAKARGASAGDSGGGDRVVNQLLTEMDG 623

  Fly   851 VEGLQGVTVIAATSRPELLDPALLRSGRIDRLVECPLPDAPARVRIFEALSSTLSLDECVDFDWF 915
            |...:.|.||.||:||:.:||||:|.||:|:|:..||||..||..|.:.......:.|.||....
pombe   624 VNSKKNVFVIGATNRPDQIDPALMRPGRLDQLIYVPLPDEEARFSILQTQLRHTPVAEDVDLRAV 688

  Fly   916 AGKTANYTGADIQSILTSANMAAVKEALAQFGHEKLAKK------------------ISLKQKHL 962
            |..|..::|||::.::..|...|:|:::    .|.:.::                  :|..|:|.
pombe   689 AKATHGFSGADLEFVVQRAVKLAIKDSI----EEDIKRENETGEAPADDVVMDEDASVSQVQRHH 749

  Fly   963 I-ESFQTTRPSLSASDVAKYHRTYAR--FTNKEKTSREF 998
            : |:.:..|.|:|.::|.:| ..||.  .|::..|..:|
pombe   750 VEEAMKMARRSVSDAEVRRY-EAYAHQLLTSRGLTGFQF 787

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pex1	NP_652016.1	PEX-1N	93..168	CDD:462729
		CDC48	365..983	CDD:273521	182/674 (27%)
		RecA-like_PEX1_r2	728..885	CDD:410934	79/158 (50%)
cdc48	NP_593287.3	CDC48	52..776	CDD:273521	210/820 (26%)