Protein Alignment Pex1 and cdc-48.2

DIOPT Version :10

• Sequence 1: NP_652016.1
• Gene: Pex1 / 45460
• FlyBaseID: FBgn0013563
• Length: 1006
• Species: Drosophila melanogaster
• Sequence 2: NP_495705.1
• Gene: cdc-48.2 / 174309
• WormBaseID: WBGene00008053
• Length: 810
• Species: Caenorhabditis elegans
• Alignment Length: 757
• Identity: 207/757 - (27%)
• Similarity: 347/757 - (45%)
• Gaps: 117/757 - (15%)

  Fly   308 ETIHPSIELNANLMKLLGIKELERVV---LRPKTTVVNFVEKIELFANKKTHYKIME-------- 361
            ||:  ||.|||:......|| :.:||   ||.:...|..:...:|...|:.|...::
 Worm    72 ETV--SIVLNADNCPNDKIK-MNKVVRNNLRSRLGDVVSISSAQLEYGKRVHVLPIDDTIEGLTG 133

  Fly   362 NAFKRFV------IERTQHKPMLFNQEEVVRLEDDLLVTVGILPEHFRYCVVDAQFLKESKIYAA 420
            |.|..|:      ..|..||..:|..:..:|..:..:|.....|.    |:|           |.
 Worm   134 NLFDVFLRPYFTDAYRPVHKGDIFTVQAAMRTVEFKVVETDPAPA----CIV-----------AP 183

  Fly   421 D-LVRPVGEIIK--EETPPTSPLSVQDL----IQLPEYDKIVDQVVQELRMNLCLSADNSVMRQC 478
            | ::...|:.||  ||....:.:...||    .||.:..::|:..::..::...:    .|....
 Worm   184 DTVIHYEGDPIKREEEEEALNEVGYDDLGGVRKQLAQIKEMVELPLRHPQLFKAI----GVKPPR 244

  Fly   479 NVLLAGASGTGKTVLVERILDQLSRKPDYCHFEFFHGSRSKGRKTESIQKDLRNIFTSCLQHAPA 543
            .:||.|..|||||::...:.::..     ..|...:|.....:.:...:.:||..|..|.:::||
 Worm   245 GILLFGPPGTGKTLIARAVANETG-----AFFFLINGPEIMSKMSGESESNLRKAFAECEKNSPA 304

  Fly   544 IVVLENLDVLAHAAGEQSSQDGEYYNRMADTVYQLIVQYTTNNAIAVIATVNELQTLNKRLSSPR 608
            |:.::.:|.:   |.::....||...|:...:..|:....|...:.|||..|...:::
 Worm   305 ILFIDEIDAI---APKREKAHGEVEKRIVSQLLTLMDGLKTRAHVVVIAATNRPNSID------- 359

  Fly   609 GRHVFQTVARLPNLERADREI------------ILRELCSHINVAKDLDLVKFSNLTEGYRKCDL 661
                    ..|....|.||||            |||....::.:.:|:||.:.:|...|:...||
 Worm   360 --------GALRRFGRFDREIDIGIPDAVGRLEILRIHTKNMKLGEDVDLEQVANECHGFVGADL 416

  Fly   662 VQFVERAIFYAYRISKTQPLLTNDQLIESLEHTNSYC--LQGIQSNQRTGNDADANEMRVE---- 720
            ......|.....| .|.:.:...|..|:: |..||..  ::..:......:.:...|..||
 Worm   417 ASLCSEAAIQQIR-EKMELIDLEDDTIDA-EVLNSLAVTMENFRFAMGKSSPSALREAVVETPNT 479

  Fly   721 ---ELPGLESVVGVLEEVLMWPSRYPTIFNASPLRNQAGVLLYGPPGTGKTYLVSQLATSWNLRI 782
               ::.||::|...|:|::.:|..:|..:....::...|||.|||||.|||.|...:|.......
 Worm   480 TWSDIGGLQNVKRELQELVQYPVEHPEKYLKFGMQPSRGVLFYGPPGCGKTLLAKAIANECQANF 544

  Fly   783 ISVKGPELLAKYIGQSEENVRNLFNRARSARPCVLFFDEFDSLAPKRG---HDSTGVTDRVVNQL 844
            ||:||||||..:.|:||.|||::|::||:|.||||||||.||:|..||   .|:.|..|||:||:
 Worm   545 ISIKGPELLTMWFGESEANVRDVFDKARAAAPCVLFFDELDSIAKARGGSVGDAGGAADRVINQV 609

  Fly   845 LTELDGVEGLQGVTVIAATSRPELLDPALLRSGRIDRLVECPLPDAPARVRIFEALSSTLSLDEC 909
            |||:||:...:.|.:|.||:||:::|||:||.||:|:|:..||||..:|::||:|......|...
 Worm   610 LTEMDGMNAKKNVFIIGATNRPDIIDPAVLRPGRLDQLIYIPLPDEASRLQIFKASLRKTPLSAD 674

  Fly   910 VDFDWFAGKTANYTGADIQSILTSANMAAVKEAL-----------------AQFGHEKLAKKI-S 956
            :|.::.|..|..::|||:..|...|...|::|::                 .:...::||..: .
 Worm   675 LDLNFLAKNTVGFSGADLTEICQRACKLAIRESIEREIRQEKERQDRSARGEELMEDELADPVPE 739

  Fly   957 LKQKHLIESFQTTRPSLSASDVAKYHRTYARFTNKEKTSREF 998
            :.:.|..|:.:..|.|::.:|:.||.    .|....:.||.|
 Worm   740 ITRAHFEEAMKFARRSVTDNDIRKYE----MFAQTLQQSRGF 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pex1	NP_652016.1	PEX-1N	93..168	CDD:462729
		CDC48	365..983	CDD:273521	184/672 (27%)
		RecA-like_PEX1_r2	728..885	CDD:410934	76/159 (48%)
cdc-48.2	NP_495705.1	CDC48	44..773	CDD:273521	204/751 (27%)