Protein Alignment MTNR1B and AstA-R2

DIOPT Version :9

• Sequence 1: NP_005950.1
• Gene: MTNR1B / 4544
• HGNCID: 7464
• Length: 362
• Species: Homo sapiens
• Sequence 2: NP_001263042.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Alignment Length: 337
• Identity: 85/337 - (25%)
• Similarity: 153/337 - (45%)
• Gaps: 53/337 - (15%)

Human    37 PWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADL--VVAFYPYPLILV 99
            ||:......|:.:|   ...|||||||.|:.|..:|:..||.:|:||.|||  |:...|:.....
  Fly    38 PWIVGFFFGVIAIT---GFFGNLLVILVVVFNNNMRSTTNLMIVNLAAADLMFVILCIPFTATDY 99

Human   100 AIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLI 164
            .::|  |..|...|::..:::.::...|::.:..::|:|:..:.|.:....:.....|.:.|..:
  Fly   100 MVYY--WPYGRFWCRSVQYLIVVTAFASIYTLVLMSIDRFLAVVHPIRSRMMRTENITLIAIVTL 162

Human   165 WLLTVVALLPNFFVGS--LEYDPR---IYS-CTFIQT---ASTQYTAAVVVIHFLLPIAVVSFCY 220
            |::.:|..:|..|...  ::||.:   .|. |||...   ....|.....:..:|||:.::|..|
  Fly   163 WIVVLVVSVPVAFTHDVVVDYDAKKNITYGMCTFTTNDFLGPRTYQVTFFISSYLLPLMIISGLY 227

Human   221 ----LRIW------VLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVA 275
                :|:|      .:..:::|..|..:||            :.||.:.||..|.|:..|.|..:
  Fly   228 MRMIMRLWRQGTGVRMSKESQRGRKRVTRL------------VVVVVIAFASLWLPVQLILLLKS 280

Human   276 INPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRRE-YKRILLALWNPRHCIQDASKG 339
            ::..|........:.||:..|||.:||:|.::|..|::|||:. ||.:        :|      .
  Fly   281 LDVIETNTLTKLVIQVTAQTLAYSSSCINPLLYAFLSENFRKAFYKAV--------NC------S 331

Human   340 SHAEGLQSPAPP 351
            |..:...|..||
  Fly   332 SRYQNYTSDLPP 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MTNR1B	NP_005950.1	7tm_4	48..>192	CDD:304433	39/151 (26%)
		7tm_1	57..308	CDD:278431	69/271 (25%)
		7tm_4	<131..>261	CDD:304433	29/148 (20%)
AstA-R2	NP_001263042.1	7tm_4	47..>164	CDD:304433	32/121 (26%)
		7tm_1	55..313	CDD:278431	69/271 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6636
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860