Protein Alignment MTNR1B and Mtnr1b

DIOPT Version :10

• Sequence 1: NP_005950.1
• Gene: MTNR1B / 4544
• HGNCID: 7464
• Length: 362
• Species: Homo sapiens
• Sequence 2: NP_663758.2
• Gene: Mtnr1b / 244701
• MGIID: 2181726
• Length: 364
• Species: Mus musculus
• Alignment Length: 351
• Identity: 284/351 - (80%)
• Similarity: 303/351 - (86%)
• Gaps: 0/351 - (0%)

Human     1 MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSV 65
            |.||.|..|||||.|.|.||.|||:..|||..|.|.|||||.||.|::||||||.||||||||||
Mouse     1 MPENSSIPNCCEASGLAARPSWSGSAGARPPVTARAPWVAPMLSTVVVVTTAVDFVGNLLVILSV 65

Human    66 LRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFN 130
            |||||||||||||:|||||||||:|.||||||||||..|||.|||.|||||||||||||||||||
Mouse    66 LRNRKLRNAGNLFVVSLALADLVIALYPYPLILVAIIRDGWVLGEAHCKASAFVMGLSVIGSVFN 130

Human   131 ITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQT 195
            ||||||||||.||||..|||:...|:||::|.|:||||:|||:||||||||||||||||||||||
Mouse   131 ITAIAINRYCCICHSTTYHRVCSHWYTPIYISLVWLLTLVALVPNFFVGSLEYDPRIYSCTFIQT 195

Human   196 ASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIF 260
            ||||||||||.||||||:||||||||||||||||||||||.|.:|.|:|||||||||||.|||:|
Mouse   196 ASTQYTAAVVAIHFLLPMAVVSFCYLRIWVLVLQARRKAKAERKLRLRPSDLRSFLTMFAVFVVF 260

Human   261 AICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLA 325
            ||||||||||||||||||:.||.|:|||||||||.||||||||||||||||||||||||||||||
Mouse   261 AICWAPLNCIGLAVAINPEAMALQVPEGLFVTSYFLAYFNSCLNAIVYGLLNQNFRREYKRILLA 325

Human   326 LWNPRHCIQDASKGSHAEGLQSPAPP 351
            :||.|.|||.|||....|..|.|.||
Mouse   326 IWNTRRCIQHASKHCLTEERQGPTPP 351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MTNR1B	NP_005950.1	7tmA_Mel1B	41..319	CDD:320522	237/277 (86%)
		TM helix 1	42..68	CDD:320522	20/25 (80%)
		TM helix 2	75..100	CDD:320522	21/24 (88%)
		TM helix 3	113..143	CDD:320522	28/29 (97%)
		TM helix 4	155..177	CDD:320522	14/21 (67%)
		TM helix 5	197..226	CDD:320522	26/28 (93%)
		TM helix 6	244..274	CDD:320522	27/29 (93%)
		TM helix 7	287..312	CDD:320522	23/24 (96%)
Mtnr1b	NP_663758.2	7tm_GPCRs	41..319	CDD:475119	237/277 (86%)
		TM helix 1	43..67	CDD:410628	19/23 (83%)
		TM helix 2	76..98	CDD:410628	18/21 (86%)
		TM helix 3	114..136	CDD:410628	21/21 (100%)
		TM helix 4	159..175	CDD:410628	9/15 (60%)
		TM helix 5	198..221	CDD:410628	20/22 (91%)
		TM helix 6	250..272	CDD:410628	19/21 (90%)
		TM helix 7	287..312	CDD:410628	23/24 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	343..364		5/9 (56%)