Protein Alignment MTNR1B and npr-31

DIOPT Version :10

• Sequence 1: NP_005950.1
• Gene: MTNR1B / 4544
• HGNCID: 7464
• Length: 362
• Species: Homo sapiens
• Sequence 2: NP_495481.2
• Gene: npr-31 / 188235
• WormBaseID: WBGene00020319
• Length: 408
• Species: Caenorhabditis elegans
• Alignment Length: 377
• Identity: 85/377 - (22%)
• Similarity: 150/377 - (39%)
• Gaps: 87/377 - (23%)

Human    39 VAPALSAVL-IVTTAVDVVGNLLVILSVLRNRKLRNAGN---------LFLVSLALADLVVAFYP 93
            ::|..:..| |.|....:.||:.|:.||.|:||.::..:         .::..||:.||.|..
 Worm     2 MSPYFAGFLYIATVLTGLFGNIWVVCSVARSRKPKSLMSRSSPSDRLRAYISVLAVIDLTVLM-- 64

Human    94 YPLILVAI--FYDGWALGEEHCKASAFVMGLSV-IGSVFNITAIAINRYCYI----CHSMAYHRI 151
             .|::.|:  |...:.|....|:| .||:..|| |.|:..::.|:|.||..|    |..:
 Worm    65 -ALLVRALYHFLPHFMLDSNSCRA-MFVLENSVKITSLTVLSCISIERYITIRKPFCSEV----- 122

Human   152 YRRWH---TPLHICLIWLLTVVALLPNFFVGSLEYD----PRIYSCTFIQTASTQYTAAVVVIHF 209
             ||..   ||:...:...|.|.|::......::..|    .|.|....|...::..||    :.|
 Worm   123 -RRQFVNATPIGASIFVGLVVGAIIVQINSVTVSSDGLNCVRSYRGKAIPRVASYLTA----VAF 182

Human   210 LLPIAVVSFCYLRIWVLVLQARRK-----------AKPESRLCLKPSDLRSFLTMFV-VFVIFAI 262
            |:.:.::|..|.:|   |...|||           ::....|..:|..:|......| |.|...:
 Worm   183 LVDLTIISLNYSQI---VRHVRRKFTKRRARVQANSRVRESLVNEPRYMREMTAAIVRVGVFHVV 244

Human   263 CWAPLNCIGLAVAINPQEMAPQIPEG----------------LFVTSYLLAYFNSCLNAIVYGLL 311
            ||.|::   |...|....:..::..|                :|:.::|.: .|:..:.|.|.::
 Worm   245 CWLPMS---LMQFIPDNTIQSELTAGIRLFSNFRDYSITRWLIFIATWLTS-MNAAGDWIFYAVM 305

Human   312 NQNFRR------EYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQH 357
            |::.|.      |.::        |..:..|:..|....|:...||.:.|.|
 Worm   306 NRDLRNLIRFATERRK--------RSTMSHAASPSTNRSLRQQVPPSMKVLH 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MTNR1B	NP_005950.1	7tmA_Mel1B	41..319	CDD:320522	76/335 (23%)
		TM helix 1	42..68	CDD:320522	8/26 (31%)
		TM helix 2	75..100	CDD:320522	6/33 (18%)
		TM helix 3	113..143	CDD:320522	13/34 (38%)
		TM helix 4	155..177	CDD:320522	5/24 (21%)
		TM helix 5	197..226	CDD:320522	7/28 (25%)
		TM helix 6	244..274	CDD:320522	9/30 (30%)
		TM helix 7	287..312	CDD:320522	6/40 (15%)
npr-31	NP_495481.2	7tm_classA_rhodopsin-like	9..306	CDD:410626	73/317 (23%)
		TM helix 1	9..32	CDD:410626	8/22 (36%)
		TM helix 2	39..73	CDD:410626	7/36 (19%)
		TM helix 3	85..115	CDD:410626	12/30 (40%)
		TM helix 4	128..145	CDD:410626	4/16 (25%)
		TM helix 5	170..195	CDD:410626	7/28 (25%)
		TM helix 6	222..270	CDD:410626	11/50 (22%)
		TM helix 7	281..306	CDD:410626	5/25 (20%)