DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment can and TAF5

DIOPT Version :9

Sequence 1:	NP_524827.1	Gene:	can / 45432	FlyBaseID:	FBgn0011569	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_009757.1	Gene:	TAF5 / 852497	SGDID:	S000000402	Length:	798	Species:	Saccharomyces cerevisiae

Alignment Length:	676	Identity:	183/676 - (27%)
Similarity:	292/676 - (43%)	Gaps:	156/676 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   322 DYEFAVKKLIKLIQSTPSHYKYEIYILLYPLLVLTYLQMMASDKIQKARMLLVRFQDHLDD---S 383
            :|..|...|...:.|:...||.|:..::||:.:..:|.::|.:.:. ||....||.....|   |
Yeast   151 NYIRAYSMLKNWVDSSLEIYKPELSYIMYPIFIYLFLNLVAKNPVY-ARRFFDRFSPDFKDFHGS 214

  Fly   384 YISRIIKLREIS--KPAEVPNKARKLLAGLEKVKIEMSEGAFRQLL------------------- 427
            .|:|:..:..|.  |..||.:..:.     .|.:|.||:.....||
Yeast   215 EINRLFSVNSIDHIKENEVASAFQS-----HKYRITMSKTTLNLLLYFLNENESIGGSLIISVIN 274

  Fly   428 -----------------------LCTEEWTRGQQEKLLSHFQIQ--PYSEDD------------K 455
                                   |...|...|:|...::...::  |:.:|:            |
Yeast   275 QHLDPNIVESVTAREKLADGIKVLSDSENGNGKQNLEMNSVPVKLGPFPKDEEFVKEIETELKIK 339

  Fly   456 PQQRFAIGQPLLEPIWYGAPEPLHKKDFAAR-------------------PFFQKRRKKRSEPQL 501
            ..|...:.|......:.||......:::.|.                   ...:...||.||.::
Yeast   340 DDQEKQLNQQTAGDNYSGANNRTLLQEYKAMNNEKFKDNTGDDDKDKIKDKIAKDEEKKESELKV 404

  Fly   502 -----SDNLHLPPVNRVYNPIPNK--MDL-LHMKSDEQYR--MKLDRNN--LPSTYLYTTSPSDE 554
                 ..||..|.  |...|:|.|  :|| |.::..::.|  :|||...  |||..:||...:::
Yeast   405 DGEKKDSNLSSPA--RDILPLPPKTALDLKLEIQKVKESRDAIKLDNLQLALPSVCMYTFQNTNK 467

  Fly   555 VVICATFSEGNSMLALGTVSSKVYVFSLKPSKLVQVKAAQWLKNLDTGMAGVDKDMIDPIKKFTR 619
            .:.|..||:...:.|.|...|.:.::||..|.         |.|.:..:...|||. ||    |.
Yeast   468 DMSCLDFSDDCRIAAAGFQDSYIKIWSLDGSS---------LNNPNIALNNNDKDE-DP----TC 518

  Fly   620 RTLYGHQGPVYGCSFNPEDRFLITCSEDFSVRLWCLLSWSCVVIFSGHLAPVCFVVFAPRGYYFA 684
            :||.||.|.||..||:|::::|::.|||.:||||.:.:.:.:|.:.||..||..|.|:|.|:|||
Yeast   519 KTLVGHSGTVYSTSFSPDNKYLLSGSEDKTVRLWSMDTHTALVSYKGHNHPVWDVSFSPLGHYFA 583

  Fly   685 TASDDCTARVWMQDNTKPARILQGHLAELGVCLFHPNRHYMATGSADCTVRIWDIVKAVQVRIFR 749
            |||.|.|||:|..|:..|.||..|||.::....||||..|:.|||:|.|.|:||:.....||:|.
Yeast   584 TASHDQTARLWSCDHIYPLRIFAGHLNDVDCVSFHPNGCYVFTGSSDKTCRMWDVSTGDSVRLFL 648

  Fly   750 GHKSRITALIYSIC--GRYLVSGGDDNLIMIWDT-ANEILMQFFDHHKASINTMEISLDNNILVV 811
            ||.:.:.::  ::|  ||:|.:|.:|.:|.:||. ..:.|.|...|.|.:|.::..|.:.|:|:.
Yeast   649 GHTAPVISI--AVCPDGRWLSTGSEDGIINVWDIGTGKRLKQMRGHGKNAIYSLSYSKEGNVLIS 711

  Fly   812 GGQDCQLTLWDFE--------------------------QVIKNYLNRAKISMKNQAGTQESSAN 850
            ||.|..:.:||.:                          |.||.|..|..:...:.
Yeast   712 GGADHTVRVWDLKKATTEPSAEPDEPFIGYLGDVTASINQDIKEYGRRRTVIPTSD--------- 767

  Fly   851 NLLVSSFFTKGEPFYMIRFTRRNLLL 876
              ||:||:||..|.:.::|:|.||.|
Yeast   768 --LVASFYTKKTPVFKVKFSRSNLAL 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
can	NP_524827.1	TAF5_NTD2	320..453	CDD:176269	34/179 (19%)
		WD40	<503..829	CDD:225201	123/361 (34%)
		WD40 repeat	591..624	CDD:293791	10/32 (31%)
		WD40	619..>823	CDD:238121	84/206 (41%)
		WD40 repeat	629..666	CDD:293791	14/36 (39%)
		WD40 repeat	672..708	CDD:293791	19/35 (54%)
		WD40 repeat	713..749	CDD:293791	15/35 (43%)
		WD40 repeat	760..790	CDD:293791	11/32 (34%)
TAF5	NP_009757.1	LisH	55..88	CDD:128913
		TFIID_NTD2	149..275	CDD:398277	29/129 (22%)
		WD40	458..722	CDD:238121	102/279 (37%)
		WD40 repeat	470..523	CDD:293791	19/66 (29%)
		WD40 repeat	529..565	CDD:293791	13/35 (37%)
		WD40 repeat	570..606	CDD:293791	20/35 (57%)
		WD40 repeat	613..648	CDD:293791	15/34 (44%)
		WD40 repeat	654..690	CDD:293791	11/37 (30%)
		WD40 repeat	697..732	CDD:293791	9/34 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346821
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0263
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1494
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003655
OrthoInspector	1	1.000	-	-		otm46886
orthoMCL	1	0.900	-	-		OOG6_102926
Panther	1	1.100	-	-	O	PTHR19879
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.650