DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment can and TAF5

DIOPT Version :9

Sequence 1:	NP_524827.1	Gene:	can / 45432	FlyBaseID:	FBgn0011569	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_197897.3	Gene:	TAF5 / 832586	AraportID:	AT5G25150	Length:	669	Species:	Arabidopsis thaliana

Alignment Length:	727	Identity:	173/727 - (23%)
Similarity:	296/727 - (40%)	Gaps:	177/727 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 DLDEQHNENKCTYWEEMSLRPVDKGEVSQEELMAILNEDES--SPDHRSECDIDEAIRTRDGSDF 295
            ||:..|::|                           |...|  |.|:.::.::.:.||:....:
plant    25 DLESYHHQN---------------------------NNGSSFTSVDYHNDPELTKLIRSFSQQE- 61

  Fly   296 YEDSAQFLENMENVSLLVIKEDSVFADYEFAVKKLIKLIQSTPSHYKYEIYILLYPLLVLTYLQM 360
             :|..::.|                     ...||.....::...||:|:..::||:.:..|:.:
plant    62 -DDPTRYRE---------------------GYSKLRSWAYNSLDLYKHELLRVMYPVFIHCYMDL 104

  Fly   361 MASDKIQKARMLLVRFQDHLDDSYISRIIKLREISKPAEVPNK--ARKLLAGLEKVKIEMSEGAF 423
            :.....|:||.....|:...:..::..:.||..:..|:.:...  ||.|..  .||.|:..:.::
plant   105 VGKGHTQEARAFFNSFRKDHEMVHLRDLQKLEGVLSPSHLEEMEFARSLRK--SKVNIKFCQYSY 167

  Fly   424 RQLLLCTEEWTRGQQEKLL-----SHFQIQPYS-------------------------------- 451
            ..||    ::.......|:     .|...|.||
plant   168 ELLL----QYLHSTVSTLMLGIINEHINFQVYSGQPTSSSDDIEAVTIVGSFQDTANHINQKEIQ 228

  Fly   452 ---------------------------------EDDKPQQRFAIGQPLLEPIWYGAPEPLHKKDF 483
                                             .||..::...||:       .|:.....|||.
plant   229 WGLLEDSLEDRLEKTGGLLSDSEKGQGESKDGDADDSKKRSTEIGK-------QGSSLKKLKKDK 286

  Fly   484 AARPFFQKRRKK----RSEPQLSDNLHLPPVNRVYNPIPNKMDLLHMKSDEQYRMKLDRNNLPST 544
            |.....:..|.:    ...|::...|.||.::     ...:..:|   .|.:.|::|....:||.
plant   287 AGNATAKVARLETITVSPAPRVKPELALPVMS-----TDVEQSIL---EDLRNRVQLSSVAMPSV 343

  Fly   545 YLYTTSPSDEVVICATFSEGNSMLALGTVSSKVYVFSLKPSKLVQVKAAQWLKNLDTGMAGVDKD 609
            ..||...:...:.|::.|...|::|.|...|.:.|:.:  :|:.|.         .:|....:.|
plant   344 SFYTFVNTHNGLNCSSISHDGSLVAGGFSDSSIKVWDM--AKIGQA---------GSGALQAEND 397

  Fly   610 MID----PIKKFTRRTLYGHQGPVYGCSFNPEDRFLITCSEDFSVRLWCLLSWSCVVIFSGHLAP 670
            ..|    |..:.:...|.||.||||..:|:|...|:::.|.|.::|||.....:.:|.:.||..|
plant   398 SSDQSIGPNGRRSYTLLLGHSGPVYSATFSPPGDFVLSSSADTTIRLWSTKLNANLVCYKGHNYP 462

  Fly   671 VCFVVFAPRGYYFATASDDCTARVWMQDNTKPARILQGHLAELGVCLFHPNRHYMATGSADCTVR 735
            |....|:|.|:|||:.|.|.|||:|..|..:|.||:.|||:::....:|||.:|:||||:|.|||
plant   463 VWDAQFSPFGHYFASCSHDRTARIWSMDRIQPLRIMAGHLSDVDCVQWHPNCNYIATGSSDKTVR 527

  Fly   736 IWDIVKAVQVRIFRGHKSRITALIYSICGRYLVSGGDDNLIMIWDTANEILMQFFDHHKASINTM 800
            :||:.....||||.||:|.:.:|..|..|||:.||.:|..||:||.:....:.....|.:.:.::
plant   528 LWDVQTGECVRIFIGHRSMVLSLAMSPDGRYMASGDEDGTIMMWDLSTARCITPLMGHNSCVWSL 592

  Fly   801 EISLDNNILVVGGQDCQLTLWDFEQVIKNYLNRAKISMKNQAGTQESSANNLLVS--SFFTKGEP 863
            ..|.:.::|..|..||.:.|||.....|  |.:|:         :::..:|.|.|  :|.||..|
plant   593 SYSGEGSLLASGSADCTVKLWDVTSSTK--LTKAE---------EKNGNSNRLRSLRTFPTKSTP 646

  Fly   864 FYMIRFTRRNLL 875
            .:.:||:|||||
plant   647 VHALRFSRRNLL 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
can	NP_524827.1	TAF5_NTD2	320..453	CDD:176269	28/204 (14%)
		WD40	<503..829	CDD:225201	105/329 (32%)
		WD40 repeat	591..624	CDD:293791	5/36 (14%)
		WD40	619..>823	CDD:238121	80/203 (39%)
		WD40 repeat	629..666	CDD:293791	11/36 (31%)
		WD40 repeat	672..708	CDD:293791	16/35 (46%)
		WD40 repeat	713..749	CDD:293791	17/35 (49%)
		WD40 repeat	760..790	CDD:293791	11/29 (38%)
TAF5	NP_197897.3	TFIID_NTD2	64..188	CDD:398277	25/150 (17%)
		WD40 repeat	357..416	CDD:293791	14/69 (20%)
		WD40	414..663	CDD:238121	98/256 (38%)
		WD40 repeat	422..458	CDD:293791	10/35 (29%)
		WD40 repeat	463..499	CDD:293791	17/35 (49%)
		WD40 repeat	506..541	CDD:293791	17/34 (50%)
		WD40 repeat	547..583	CDD:293791	12/35 (34%)
		WD40 repeat	589..622	CDD:293791	9/34 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0263
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D620721at2759
OrthoFinder	1	1.000	-	-		FOG0003655
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102926
Panther	1	1.100	-	-	O	PTHR19879
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.780