DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment can and DNAI4

DIOPT Version :9

Sequence 1:	NP_524827.1	Gene:	can / 45432	FlyBaseID:	FBgn0011569	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_079039.4	Gene:	DNAI4 / 79819	HGNCID:	26252	Length:	848	Species:	Homo sapiens

Alignment Length:	851	Identity:	156/851 - (18%)
Similarity:	288/851 - (33%)	Gaps:	253/851 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ISDSDDSDSDDIRNELMKLEDNKDKPKNKERQKSKNENSQIKMNKWYLKEFEDL-MGLEIACSDD 81
            :|.|..|.|:.|      .||.::....:||..|..:...|:.....:...||| ..:||..::.
Human   185 VSKSSVSASESI------AEDLEEPSYKRERLTSFTDLQVIRAAPEKIVTKEDLEKNIEIILTET 243

  Fly    82 ED----DIDDRNSEIWSSSESDKISDSDDS------NSDGSPTEWINRIKNVNLFPFNKSAEDEK 136
            |.    |:......: .|.|::|::..:.:      |..|:.......::..|..|.||..:
Human   244 ETLRFFDLPTVMVSV-ESEEAEKVTQRNKNYEVLCRNRLGNDLYVERMMQTFNGAPKNKDVQ--- 304

  Fly   137 PKACEELPSIPVFTGPM-PSMPIYDEETCQFEMVPPIIQPDLIKEVTDAEMPIELDKSDSELEKE 200
               |:::  |....|.| .:..:||.... .|:|...::..:::..:.|.:
Human   305 ---CDKI--IMEDKGIMSTAWDLYDSYNA-MELVSLSVKQSVVESSSKANV-------------- 349

  Fly   201 KLKADEDDNFSDSNTSSSFSLSSLDDYDYGETDLDEQHNENKCTYWEEMSLRPVDKGEVSQEELM 265
             |..|:|.....|.|..:...|||.|.                                 :..::
Human   350 -LPKDQDQRLPGSTTEKNSETSSLMDI---------------------------------ENVIL 380

  Fly   266 AILNEDESSPDHRSECDIDEAIRTRDGSDFYEDSAQFLENMENVSLLVIKEDSVFADYEFAVKKL 330
            |.::|||.  ||      .:||...|  .|::|    |..||.|.:     :::|.....|.::|
Human   381 AKIHEDEE--DH------SDAILKSD--KFHQD----LFFMERVLM-----ENIFQPKLAAYRQL 426

  Fly   331 IKLIQSTPSHYKYEIYILLYPLLVLTYLQMMASDKIQKARMLLVRFQDHLDDSYISRIIKLREI- 394
            ..|.:..|..                     ..|.::.|:        |.:....|:..:..||
Human   427 PVLKEPEPEE---------------------PEDVLESAK--------HEEVEEESKKEEEEEIH 462

  Fly   395 SKPAEVPNKARKLLAGLEKV---KIEMSEGAFRQLLLCTEEWTRGQQEKL---LSHFQIQPYSED 453
            ::.:.:|       |.||::   ..::::|    |.:.:..|.:...:.|   ..||..
Human   463 AEESTIP-------ANLERLWSFSCDLTKG----LNVSSLAWNKTNPDLLAVGYGHFGF------ 510

  Fly   454 DKPQQR-FAIGQPLLEPIW----YGAPEPLHKKDFAARPFFQKRRKKRSEPQL------------ 501
             |.|:| .|....:..|:|    |.:|..:...||:.           ..|.|
Human   511 -KEQKRGLACCWSIKNPMWPERIYQSPYGVTAVDFSI-----------GAPNLLAVGYHNGTIAI 563

  Fly   502 ---SDNLHLPPVNRVYNPIPNKMDLLHMKSDEQYRMKLDRNNLPSTYLYTTSPSDEVVICATFSE 563
               ..|.::|.::...:|..:...:..::..||     ||..       |.....|:::
Human   564 YNVRSNSNVPVLDSSESPQKHLGPVWQLQWIEQ-----DRGT-------TGDGKREILV------ 610

  Fly   564 GNSMLALGTVSSKVYVFSLKPSKLVQVKAAQWLKNLDTGMAGVDKDMIDPIKKFTRRTLYGHQGP 628
              |:.|.|.:|..|....|....|:::|......|    ..|.:|:..|       ..|...|.|
Human   611 --SISADGRISKWVIRKGLDCYDLMRLKRTTAASN----KKGGEKEKKD-------EALISRQAP 662

  Fly   629 VYGCSFNPEDR--FLITCSEDFSVRLWCLLSWSCVVIFSGHLAPVCFVVFAPRGY-YFATASDDC 690
            ....:|:|:|.  :|....|....:..|..:...:..:.||..||..|.:.|..: .|.:.|.|.
Human   663 GMCFAFHPKDTNIYLAGTEEGHIHKCSCSYNEQYLDTYRGHKGPVYKVTWNPFCHDVFLSCSADW 727

  Fly   691 TARVWMQDNTKPARILQGHLAELGVCLFHPNRHYMATGSADCTVRIWDIVKAVQVRIFRGHKSRI 755
            ...:|.|:|.||:.......:.:....:.|...|:...:.:..|.|||:           |.|.:
Human   728 GVIIWQQENVKPSLSFYPATSVVYDVAWSPKSSYIFAAANENRVEIWDL-----------HISTL 781

  Fly   756 TALIYSICGRYLVSGGDDNLIMIWDTANEILMQFFDHHKASINTMEISLDNNILVVGGQDCQLTL 820
            ..||.                   :|||..:         ...|:..:...:.|:||..|.|:::
Human   782 DPLIV-------------------NTANPGI---------KFTTILFAKQTDCLLVGDSDGQVSV 818

  Fly   821 WDFEQV 826
            ::...:
Human   819 YELRNM 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
can	NP_524827.1	TAF5_NTD2	320..453	CDD:176269	21/139 (15%)
		WD40	<503..829	CDD:225201	63/327 (19%)
		WD40 repeat	591..624	CDD:293791	6/32 (19%)
		WD40	619..>823	CDD:238121	42/206 (20%)
		WD40 repeat	629..666	CDD:293791	6/38 (16%)
		WD40 repeat	672..708	CDD:293791	10/36 (28%)
		WD40 repeat	713..749	CDD:293791	6/35 (17%)
		WD40 repeat	760..790	CDD:293791	3/29 (10%)
DNAI4	NP_079039.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	345..370		6/39 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	431..464		7/61 (11%)
		WD40	<485..845	CDD:225201	81/432 (19%)
		WD40 repeat	489..534	CDD:293791	10/51 (20%)
		WD40	493..775	CDD:295369	64/330 (19%)
		WD 1. /evidence=ECO:0000255	534..574		6/50 (12%)
		WD40 repeat	539..576	CDD:293791	6/47 (13%)
		WD 2. /evidence=ECO:0000255	583..631		12/67 (18%)
		WD40 repeat	589..640	CDD:293791	14/70 (20%)
		WD 3. /evidence=ECO:0000255	658..698		8/39 (21%)
		WD40 repeat	663..698	CDD:293791	6/34 (18%)
		WD 4. /evidence=ECO:0000255	702..742		14/39 (36%)
		WD40 repeat	707..744	CDD:293791	11/36 (31%)
		WD 5. /evidence=ECO:0000255	745..784		8/49 (16%)
		WD40 repeat	751..786	CDD:293791	9/45 (20%)
		WD 6. /evidence=ECO:0000255	790..829		7/44 (16%)
		WD40 repeat	793..830	CDD:293791	6/41 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0263
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900