DRSC/TRiP Functional Genomics Resources

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Protein Alignment can and TAF5

DIOPT Version :10

Sequence 1:NP_524827.1 Gene:can / 45432 FlyBaseID:FBgn0011569 Length:942 Species:Drosophila melanogaster
Sequence 2:NP_008882.2 Gene:TAF5 / 6877 HGNCID:11539 Length:800 Species:Homo sapiens


Alignment Length:622 Identity:186/622 - (29%)
Similarity:307/622 - (49%) Gaps:69/622 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   303 LENMENVSLLVIK-----EDSVFADYEFAVKKLIKLIQSTPSHYKYEIYILLYPLLVLTYLQMMA 362
            :|:..:||.::..     :.:::.:|...:|..|:.  |...| :.|:..|.|||.|..||:::.
Human   192 VEDQPDVSAVLSAYNQQGDPTMYEEYYSGLKHFIEC--SLDCH-RAELSQLFYPLFVHMYLELVY 253

  Fly   363 SDKIQKARMLLVRFQDHLDDSYISRIIKLREISKPAEVPNKARKLLAGLEKVKIEMSEGAFRQLL 427
            :....:|:....:|....:..|...:..|..::|...:......|.....|..:.:|..:::.|.
Human   254 NQHENEAKSFFEKFHGDQECYYQDDLRVLSSLTKKEHMKGNETMLDFRTSKFVLRISRDSYQLLK 318

  Fly   428 LCTEE------WTRGQQEKLLSHFQIQPYSEDDKPQQRFAI-----GQPLLE----PIWYG---A 474
            ...:|      |...|:...:..|...|.|:    ||..|:     |:...|    .:::|   .
Human   319 RHLQEKQNNQIWNIVQEHLYIDIFDGMPRSK----QQIDAMVGSLAGEAKREANKSKVFFGLLKE 379

  Fly   475 PE---PLHKKD-----FAARPFFQKRRK-------KRSEPQLSDNLHLPPVNRVYNPIP-----N 519
            ||   ||..:|     ...:|..:|.:|       |:.:|      :.||.||:  |:|     :
Human   380 PEIEVPLDDEDEEGENEEGKPKKKKPKKDSIGSKSKKQDP------NAPPQNRI--PLPELKDSD 436

  Fly   520 KMD-LLHMKSDEQYRMKLDRNNLPSTYLYTTSPSDEVVICATFSEGNSMLALGTVSSKVYVFSLK 583
            |:| :::||...: |::|..:.|||...||...:.:.:.....::.:|::|.|...|.|.|:|:.
Human   437 KLDKIMNMKETTK-RVRLGPDCLPSICFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVT 500

  Fly   584 PSKLVQVKAAQWLKNLDTGMAGVDKDMIDPIKKFTRRTLYGHQGPVYGCSFNPEDRFLITCSEDF 648
            |.||..||.|..|..:|.....|.:.::|.......:.||||.|||||.||:|:..:|::.|||.
Human   501 PKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDG 565

  Fly   649 SVRLWCLLSWSCVVIFSGHLAPVCFVVFAPRGYYFATASDDCTARVWMQDNTKPARILQGHLAEL 713
            :||||.|.:::|:|.:.||..||....|:|.||||.:...|..||:|..|:.:|.||..||||::
Human   566 TVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADV 630

  Fly   714 GVCLFHPNRHYMATGSADCTVRIWDIVKAVQVRIFRGHKSRITALIYSICGRYLVSGGDDNLIMI 778
            ....||||.:|:||||||.|||:||::....||||.|||..|.:|.:|..||:|.:|..|..:::
Human   631 NCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLL 695

  Fly   779 WDTANEILMQFFDHHKASINTMEISLDNNILVVGGQDCQLTLWD----FEQVIKNYLNRAKISMK 839
            ||..:.:::.....|..::.::..|.|..||..|..|..:.|||    ||.:..:....|...:.
Human   696 WDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHIN 760

  Fly   840 NQAGTQESSANNLLVSSFFTKGEPFYMIRFTRRNLLL 876
            ....:||     ||:.::.||..|...:.||||||:|
Human   761 LPENSQE-----LLLGTYMTKSTPVVHLHFTRRNLVL 792

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
canNP_524827.1 TAF5_NTD2 320..453 CDD:176269 28/138 (20%)
WD40 repeat 591..624 CDD:293791 7/32 (22%)
WD40 619..>823 CDD:238121 88/207 (43%)
WD40 repeat 629..666 CDD:293791 17/36 (47%)
WD40 repeat 672..708 CDD:293791 14/35 (40%)
WD40 repeat 713..749 CDD:293791 19/35 (54%)
WD40 repeat 760..790 CDD:293791 8/29 (28%)
TAF5NP_008882.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..74
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 153..189
NTD2, involved in homo-dimerization, also involved in TFIID-TFIIF contacts in the RNA Pol II pre-initiation complex (PIC). /evidence=ECO:0000303|PubMed:33795473, ECO:0007744|PDB:2NXP 194..340 27/148 (18%)
TFIID_NTD2 208..337 CDD:461330 25/131 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 384..438 14/61 (23%)
WD40 <456..740 CDD:441893 109/283 (39%)
WD 1. /evidence=ECO:0000255 468..507 10/38 (26%)
WD40 repeat 473..541 CDD:293791 18/67 (27%)
WD 2. /evidence=ECO:0000255 541..580 20/38 (53%)
WD40 repeat 547..583 CDD:293791 16/35 (46%)
WD 3. /evidence=ECO:0000255 583..624 18/40 (45%)
WD40 repeat 588..624 CDD:293791 15/35 (43%)
WD 4. /evidence=ECO:0000255 625..666 23/40 (58%)
WD40 repeat 631..666 CDD:293791 19/34 (56%)
WD 5. /evidence=ECO:0000255 667..706 13/38 (34%)
WD40 repeat 672..708 CDD:293791 10/35 (29%)
WD 6. /evidence=ECO:0000255 709..748 12/38 (32%)
WD40 repeat 714..756 CDD:293791 11/41 (27%)
Blue background indicates that the domain is not in the aligned region.

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