DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment can and taf5l

DIOPT Version :9

Sequence 1:	NP_524827.1	Gene:	can / 45432	FlyBaseID:	FBgn0011569	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_001006779.1	Gene:	taf5l / 448469	XenbaseID:	XB-GENE-998039	Length:	588	Species:	Xenopus tropicalis

Alignment Length:	628	Identity:	160/628 - (25%)
Similarity:	253/628 - (40%)	Gaps:	175/628 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   323 YEFAVKKLIKLIQSTPSHYKYEIYILLYPLLVLTYLQMMASDKIQKARMLLVRFQDHLDDSYISR 387
            ||....:|...:....|.:..|:..|||||.|..:|     |.:|.:....|       ||:.||
Frog    70 YEVQFARLRNFLSDADSPHSQEVTTLLYPLFVYLHL-----DMVQNSLKSAV-------DSFYSR 122

  Fly   388 -------------IIKLREISKPAEVPNKARKLLAGLE-KVKIEMSEGAFRQLL----------L 428
                         |::..:.:...:..:...||.|.|: |..:.:.|.::..||          |
Frog   123 FHGMFMQHPGQRDIVEQLQTTMTMQDIHSNCKLRAFLDNKYVVCLQEDSYHYLLRFLQSDNNTAL 187

  Fly   429 CTEEWTRGQQEKLLSHFQIQPYSEDDKPQQRFAIGQPLLEPIWYGAPEPLHKKDFAARPFFQKRR 493
            |         :.|..|.|:.                  ::|:
Frog   188 C---------KALALHIQLD------------------VQPV----------------------- 202

  Fly   494 KKRSEPQLSDNLHLPPVNRVYNPIPNKMDLLHMKSDEQYRMKLDRNNLPSTYLYTTSPSDEVVIC 558
             ||:|.||            ||.:.:        |.......||::::|:..|...:..|::..|
Frog   203 -KRTEYQL------------YNSMGS--------SSRGENNSLDQSDVPTPILQNEAALDQLQDC 246

  Fly   559 ----------------------------ATFSEGNSMLALGTVSSKVYVFSLKPSKL------VQ 589
                                        |..|..:.:||.|..||.|.::|||..||      |.
Frog   247 IKKVKDGPPSLTTISFYAFYNTEQLLNTAEISPDSRLLAAGFDSSCVKLWSLKSKKLKAEPHRVD 311

  Fly   590 VK----AAQWLKNLDTGMAGVDKDMIDPIKKFTRRTLYGHQGPVYGCSFNPEDRFLITCSEDFSV 650
            |.    |...|:..:...||.:           .:.|.||.||||...|..:...|::||||.|:
Frog   312 VSRIRLACDVLEEEEDEQAGTE-----------MKILRGHSGPVYRTCFLSDSSGLLSCSEDTSI 365

  Fly   651 RLWCLLSWSCVVIFSGHLAPVCFVVFAPRGYYFATASDDCTARVWMQDNTKPARILQGHLAELGV 715
            |.|.|.:::..|::.||..||..:..:|...:||:||.|.|.|:|..|.|.|.||..|||:::..
Frog   366 RYWNLENFTNTVLYQGHAHPVWDLDVSPCSLFFASASHDRTGRLWCFDRTFPLRIYAGHLSDVDC 430

  Fly   716 CLFHPNRHYMATGSADCTVRIWDIVKAVQVRIFRGHKSRITALIYSICGRYLVSGGDDNLIMIWD 780
            ..||||.:|:||||.|.|||:|...:...||:|.||:..:.||.:|..|:||.|.|:|..:.:||
Frog   431 IKFHPNSNYLATGSTDKTVRLWSTQQGNSVRLFTGHRGPVLALAFSPNGKYLASAGEDQRLKLWD 495

  Fly   781 TANEILMQFFDHHKASINTMEISLDNNILVVGGQDCQLTLWDFEQVIKN-YLNRAKISMKNQAGT 844
            .|:..|.:....|..:|:::..|.|::::.....|..:.:||    |:| |.|           |
Frog   496 LASGTLYKELRGHTDNISSLTFSPDSSLIASASMDNSVRVWD----IRNSYCN-----------T 545

  Fly   845 QESSANNLLVSSFFTKGEPFYMIRFTRRNLLLGFCVTPREFEN 887
            ....:::.||..:..:......::|...|||:   ||....||
Frog   546 PSDGSSSELVGVYTGQTSNILSVQFMACNLLM---VTGIAHEN 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
can	NP_524827.1	TAF5_NTD2	320..453	CDD:176269	33/153 (22%)
		WD40	<503..829	CDD:225201	107/363 (29%)
		WD40 repeat	591..624	CDD:293791	5/36 (14%)
		WD40	619..>823	CDD:238121	77/203 (38%)
		WD40 repeat	629..666	CDD:293791	13/36 (36%)
		WD40 repeat	672..708	CDD:293791	14/35 (40%)
		WD40 repeat	713..749	CDD:293791	16/35 (46%)
		WD40 repeat	760..790	CDD:293791	11/29 (38%)
taf5l	NP_001006779.1	TAF5_NTD2	69..201	CDD:176269	33/169 (20%)
		WD40	<256..406	CDD:225201	47/160 (29%)
		WD40 repeat	274..339	CDD:293791	20/75 (27%)
		WD40	333..580	CDD:238121	90/275 (33%)
		WD40 repeat	345..381	CDD:293791	12/35 (34%)
		WD40 repeat	386..422	CDD:293791	15/35 (43%)
		WD40 repeat	429..464	CDD:293791	16/34 (47%)
		WD40 repeat	470..506	CDD:293791	13/35 (37%)
		WD40 repeat	512..559	CDD:293791	13/61 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D230914at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19879
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020