DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment can and wda

DIOPT Version :9

Sequence 1:	NP_524827.1	Gene:	can / 45432	FlyBaseID:	FBgn0011569	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_651136.1	Gene:	wda / 42750	FlyBaseID:	FBgn0039067	Length:	743	Species:	Drosophila melanogaster

Alignment Length:	792	Identity:	154/792 - (19%)
Similarity:	285/792 - (35%)	Gaps:	196/792 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 SLSSLDDYDYGETDLDEQHNENKCTYWEEMSLRPVD------------KGEVSQE-----ELMAI 267
            ||.|..::.:..:.:....|.||.:...:.:....|            |..||.|     :.:.:
  Fly     2 SLPSASNHAHAASPVYSNSNNNKSSASSKKTSSKNDLLRCAVGLLLKQKNYVSNERFRRSDFLLL 66

  Fly   268 LNEDESSPDHRSECDIDEAIRTRDGSDFYEDSAQFLENMENVSLLVIKEDSVFADYEFAVKKLIK 332
            .|:.:.:.:...:.|:      ..|:.|...:.|.:.|.::.           .|.:|.  :..:
  Fly    67 QNKQQFAVNKMLDTDL------HGGNSFTFSNVQVITNNQHT-----------VDQQFG--RFSQ 112

  Fly   333 LIQSTPSHYKYEIYILLYPLLVLTYLQMMASDKIQKARMLLVRFQDHLDDSYISRIIKLREISKP 397
            .:::.....:.|:.....|:|...||.::.:.:.:.|..||.::      :::...:.:.:...|
  Fly   113 FVEAQAEPLRLEMKRFYGPMLCHFYLDLLKAREPRGAVELLRKY------AHLVAPVDMYDAPPP 171

  Fly   398 AEV---PNKARKLLAGLEKVKIEMSEG-----AFRQLLLCTEEWTR---GQQEKLLSHFQIQPYS 451
            .::   ...|.:....:...|.....|     .|.:|:.....:||   .:.:..::||:...|.
  Fly   172 TKINGCSTTANESTFNIRFAKEAQDTGDTELDYFMRLVQTLSGYTRLEAAESDDTVAHFRSSKYE 236

  Fly   452 EDDKP----------QQRFAIGQPLLEPIWY---------------------GAPEPLH----KK 481
            .....          |:|   |..|:..:.|                     |..:.|.    :.
  Fly   237 LHTTAVVVNRICAYLQRR---GHVLIMNLLYTWLHVHIVENEQRAFSEDHLLGLTDDLEGEDGED 298

  Fly   482 DFAARP---------------FFQKRRKKRSEPQLSDNLHL-------------PPVNRVYNPIP 518
            |..::|               ..:|..:||  |....|:.|             ..::::...|.
  Fly   299 DVVSKPAVTLNTRGDIRPSKSLTEKSNRKR--PAEEPNIMLETDIKQEVETDESAELSKLQLNID 361

  Fly   519 NKMDLLHMKSDE--QYRMKLDR--------NNLPSTYLYTTSPSDEVVICATFSEGNSMLALGTV 573
            ..:|.|...:::  :.:::|.|        ..|.|.:|   .||:    |       .||| |..
  Fly   362 ACLDTLKSATEQILKSQVELPRFLRISERSRGLTSAHL---DPSE----C-------HMLA-GFD 411

  Fly   574 SSKVYVFSLKPS--------KLVQVKAAQW-LKNLDTGMAGVDKDMIDPIKKFT---RR------ 620
            :|.|.::.|..|        :....|...| |.|........|:|..|...|.:   ||
  Fly   412 NSAVQLWQLNQSYCRGKSFYRRYPQKRCPWELNNCANQEEETDEDSSDEDVKCSEEERRERNRAR 476

  Fly   621 ---------------TLYGHQGPVYGCSFNPEDRFLITCSEDFSVRLWCLLSWSCVVIFSGHLAP 670
                           .|.||...|....|:.....:.:.|:|.::|.|...:..|..|:..|..|
  Fly   477 HCKYADNSYNEYGGFQLRGHTKGVTDVRFSAHYPLMYSVSKDATMRCWRAHNLHCAAIYRSHNYP 541

  Fly   671 VCFVVFAPRGYYFATASDDCTARVWMQDNTKPARILQGHLAELGVCLFHPNRHYMATGSADCTVR 735
            :..:..:|.|.|..|.|.|.:||:|..:......|..||..::....||||.:|:||||||.:||
  Fly   542 IWCLDESPVGQYVVTGSKDLSARLWSLEKEHALIIYAGHTQDVECVAFHPNGNYIATGSADHSVR 606

  Fly   736 IWDIVKAVQVRIFRGHKSRITALIYSICGRYLVSGGDDNLIMIWDTANEILMQFFDHHKASINTM 800
            :|.......:|:|...:..:|.|.:|..|:.|.:.|::..:.|:|.|....:.....|.|||:::
  Fly   607 LWCATSGKLMRVFADCRQAVTQLAFSPDGKMLAAAGEETKVRIFDLAAGAQLAELKDHSASISSL 671

  Fly   801 EISLDNNILVVGGQDCQLTLWDFEQVIKNYLNRAKISMKNQAGTQESSANN----------LLVS 855
            ..|..|..|.....|..|.|||.:::       :.:|..:.||:..|:..|          .||.
  Fly   672 SWSTHNRHLATACSDGTLRLWDIKKL-------SPMSDNSSAGSSSSATTNRVLTVNSSCQRLVD 729

  Fly   856 SFFTKGEPFYMI 867
            .|:...:..|.|
  Fly   730 VFYGTSKTLYCI 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
can	NP_524827.1	TAF5_NTD2	320..453	CDD:176269	21/143 (15%)
		WD40	<503..829	CDD:225201	93/381 (24%)
		WD40 repeat	591..624	CDD:293791	11/57 (19%)
		WD40	619..>823	CDD:238121	63/224 (28%)
		WD40 repeat	629..666	CDD:293791	8/36 (22%)
		WD40 repeat	672..708	CDD:293791	10/35 (29%)
		WD40 repeat	713..749	CDD:293791	15/35 (43%)
		WD40 repeat	760..790	CDD:293791	7/29 (24%)
wda	NP_651136.1	TAF5_NTD2	104..273	CDD:298747	26/179 (15%)
		WD40	324..>700	CDD:225201	96/399 (24%)
		WD40	491..700	CDD:238121	62/215 (29%)
		WD40 repeat	501..537	CDD:293791	7/35 (20%)
		WD40 repeat	542..578	CDD:293791	10/35 (29%)
		WD40 repeat	585..619	CDD:293791	15/33 (45%)
		WD40 repeat	626..662	CDD:293791	9/35 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45473215
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D230914at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19879
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950