DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment can and Taf5

DIOPT Version :9

Sequence 1:	NP_524827.1	Gene:	can / 45432	FlyBaseID:	FBgn0011569	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_001099835.1	Gene:	Taf5 / 294018	RGDID:	1311332	Length:	798	Species:	Rattus norvegicus

Alignment Length:	622	Identity:	186/622 - (29%)
Similarity:	307/622 - (49%)	Gaps:	69/622 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 LENMENVSLLVIK-----EDSVFADYEFAVKKLIKLIQSTPSHYKYEIYILLYPLLVLTYLQMMA 362
            :|:..:||.::..     :.:::.:|...:|..|:.  |...| :.|:..|.|||.|..||:::.
  Rat   190 VEDQPDVSAVLSAYNQQGDPTMYEEYYSGLKHFIEC--SLDCH-RAELSQLFYPLFVHMYLELVY 251

  Fly   363 SDKIQKARMLLVRFQDHLDDSYISRIIKLREISKPAEVPNKARKLLAGLEKVKIEMSEGAFRQLL 427
            :....:|:....:|....:..|...:..|..::|...:......|.....|..:.:|..:::.|.
  Rat   252 NQHESEAKSFFEKFHGDQECYYQDDLRVLSSLTKKEHMKGNETMLDFRTSKFVLRISRDSYQLLK 316

  Fly   428 LCTEE------WTRGQQEKLLSHFQIQPYSEDDKPQQRFAI-----GQPLLE----PIWYG---A 474
            ...:|      |...|:...:..|...|.|:    ||..|:     |:...|    .:::|   .
  Rat   317 RHLQEKQNNQIWNIVQEHLYIDIFDGMPRSK----QQIDAMVGSLAGEAKREANKSKVFFGLLKE 377

  Fly   475 PE---PLHKKD-----FAARPFFQKRRK-------KRSEPQLSDNLHLPPVNRVYNPIP-----N 519
            ||   ||..:|     ...:|..:|.:|       |:.:|      :.||.||:  |:|     :
  Rat   378 PEIEVPLDDEDEEGENEEGKPKKKKPKKDSIGSKSKKQDP------NAPPQNRI--PLPELKDSD 434

  Fly   520 KMD-LLHMKSDEQYRMKLDRNNLPSTYLYTTSPSDEVVICATFSEGNSMLALGTVSSKVYVFSLK 583
            |:| :::||...: |::|..:.|||...||...:.:.:.....::.:|::|.|...|.|.|:|:.
  Rat   435 KLDKIMNMKETTK-RVRLGPDCLPSICFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVT 498

  Fly   584 PSKLVQVKAAQWLKNLDTGMAGVDKDMIDPIKKFTRRTLYGHQGPVYGCSFNPEDRFLITCSEDF 648
            |.||..||.|..|..:|.....|.:.::|.......:.||||.|||||.||:|:..:|::.|||.
  Rat   499 PKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDG 563

  Fly   649 SVRLWCLLSWSCVVIFSGHLAPVCFVVFAPRGYYFATASDDCTARVWMQDNTKPARILQGHLAEL 713
            :||||.|.:::|:|.:.||..||....|:|.||||.:...|..||:|..|:.:|.||..||||::
  Rat   564 TVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADV 628

  Fly   714 GVCLFHPNRHYMATGSADCTVRIWDIVKAVQVRIFRGHKSRITALIYSICGRYLVSGGDDNLIMI 778
            ....||||.:|:||||||.|||:||::....||||.|||..|.:|.:|..||:|.:|..|..:::
  Rat   629 NCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLL 693

  Fly   779 WDTANEILMQFFDHHKASINTMEISLDNNILVVGGQDCQLTLWD----FEQVIKNYLNRAKISMK 839
            ||..:.:::.....|..::.::..|.|..||..|..|..:.|||    ||.:..:....|...:.
  Rat   694 WDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHIN 758

  Fly   840 NQAGTQESSANNLLVSSFFTKGEPFYMIRFTRRNLLL 876
            ....:||     ||:.::.||..|...:.||||||:|
  Rat   759 LPENSQE-----LLLGTYMTKSTPVVHLHFTRRNLVL 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
can	NP_524827.1	TAF5_NTD2	320..453	CDD:176269	28/138 (20%)
		WD40	<503..829	CDD:225201	124/335 (37%)
		WD40 repeat	591..624	CDD:293791	7/32 (22%)
		WD40	619..>823	CDD:238121	88/207 (43%)
		WD40 repeat	629..666	CDD:293791	17/36 (47%)
		WD40 repeat	672..708	CDD:293791	14/35 (40%)
		WD40 repeat	713..749	CDD:293791	19/35 (54%)
		WD40 repeat	760..790	CDD:293791	8/29 (28%)
Taf5	NP_001099835.1	TAF5_NTD2	209..341	CDD:176269	25/134 (19%)
		WD40	<457..738	CDD:225201	108/280 (39%)
		WD40	470..737	CDD:238121	103/266 (39%)
		WD40 repeat	471..539	CDD:293791	18/67 (27%)
		WD40 repeat	545..581	CDD:293791	16/35 (46%)
		WD40 repeat	586..622	CDD:293791	15/35 (43%)
		WD40 repeat	629..664	CDD:293791	19/34 (56%)
		WD40 repeat	670..706	CDD:293791	10/35 (29%)
		WD40 repeat	712..754	CDD:293791	11/41 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354554
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0263
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D230914at33208
OrthoFinder	1	1.000	-	-		FOG0003655
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102926
Panther	1	1.100	-	-	O	PTHR19879
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.710