DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment can and Taf5l

DIOPT Version :9

Sequence 1:	NP_524827.1	Gene:	can / 45432	FlyBaseID:	FBgn0011569	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_001344244.1	Gene:	Taf5l / 102162	MGIID:	1919039	Length:	589	Species:	Mus musculus

Alignment Length:	576	Identity:	154/576 - (26%)
Similarity:	249/576 - (43%)	Gaps:	67/576 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   323 YEFAVKKLIKLIQSTPSHYKYEIYILLYPLLVLTYLQMMASDKIQKARMLLVRFQD-HLDDSYIS 386
            ||....:|...:..:.|.|..|:..|||||.|..:|.::.|...........||.. .|.::...
Mouse    70 YEVQFGRLRSFLTDSDSQYSREVMPLLYPLFVYLHLNLVQSGPKSTVESFYSRFHGMFLQNASQK 134

  Fly   387 RIIKLREISKPAEVPNKARKLLAGLE-KVKIEMSEGAFRQLLLCTEEWTRGQQEKLLS---HFQI 447
            .:|:..:.::..:......:|.|.|: |..:.:.|.::..|:...:........|:|:   |..:
Mouse   135 DVIEQLQTTQTIQDILSNFQLRAFLDNKYVVRLQEDSYNYLIRYLQSDNNTALCKVLAVHIHLDV 199

  Fly   448 QPYSEDDKPQQRFAIGQPLLEPIWYGAPEPLHKKDFAARPFFQKRRKKRSEPQLSDNLHLPPVNR 512
            ||....|  .|.:|.|         |:..                         ::|..|.| ..
Mouse   200 QPAKRTD--YQLYASG---------GSSR-------------------------TENSSLEP-PE 227

  Fly   513 VYNPIPNKMDLLHMKSDEQYRMKLDRNNLPSTYLYTTSPSDEVVICATFSEGNSMLALGTVSSKV 577
            |.:||......|.:..:...|:|....:|.:...|....:::::..|..|..:.:||.|..:|.:
Mouse   228 VPSPILQNEAALEVLQESIKRVKDGPPSLTTICFYAFYNTEQLLNTAEISSDSKLLAAGFDNSCI 292

  Fly   578 YVFSLKPSKLVQVKAAQWLKNLDTGMAGVDKDMIDPIKKFTRRT------LYGHQGPVYGCSFNP 636
            .::||:..||....     .::||....:..|.::..:.....|      |.||.||||...|..
Mouse   293 KLWSLRSKKLKSEP-----HHVDTSRIRLACDTLEEEENEEDNTGTEMKILRGHCGPVYSTRFLA 352

  Fly   637 EDRFLITCSEDFSVRLWCLLSWSCVVIFSGHLAPVCFVVFAPRGYYFATASDDCTARVWMQDNTK 701
            :...|::||||.|:|.|.|.|::..|::.||..||..|..:|...|||:.|.|.|||:|..|.|.
Mouse   353 DSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDVDISPFSLYFASGSHDRTARLWSFDRTY 417

  Fly   702 PARILQGHLAELGVCLFHPNRHYMATGSADCTVRIWDIVKAVQVRIFRGHKSRITALIYSICGRY 766
            |.||..||||::....||||.:|:||||.|.|||:|...:...||:|.||:..:.:|.:|..|:|
Mouse   418 PLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLSFSPNGKY 482

  Fly   767 LVSGGDDNLIMIWDTANEILMQFFDHHKASINTMEISLDNNILVVGGQDCQLTLWDFEQVIKNYL 831
            |.|.|:|..:.:||.|:..|.:....|..||.::..|.|:.::.....|..:.:||......|
Mouse   483 LASAGEDQRLKLWDLASGTLFKELRGHTDSITSLAFSPDSGLIASASMDNSVRVWDIRSTCCN-- 545

  Fly   832 NRAKISMKNQAGTQESSANNLLVSSFFTKGEPFYMIRFTRRNLLLGFCVTPREFEN 887
            ..|..|.....|......:|:|            .::|...||||...:|....|:
Mouse   546 TPADGSSGELVGVYTGQMSNVL------------SVQFMACNLLLVTGITQENQEH 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
can	NP_524827.1	TAF5_NTD2	320..453	CDD:176269	29/134 (22%)
		WD40	<503..829	CDD:225201	107/331 (32%)
		WD40 repeat	591..624	CDD:293791	5/38 (13%)
		WD40	619..>823	CDD:238121	82/209 (39%)
		WD40 repeat	629..666	CDD:293791	14/36 (39%)
		WD40 repeat	672..708	CDD:293791	16/35 (46%)
		WD40 repeat	713..749	CDD:293791	16/35 (46%)
		WD40 repeat	760..790	CDD:293791	11/29 (38%)
Taf5l	NP_001344244.1	TAF5_NTD2	67..201	CDD:176269	27/130 (21%)
		WD 1	266..305		10/38 (26%)
		WD40	276..581	CDD:238121	106/323 (33%)
		WD 2	340..379		17/38 (45%)
		WD40 repeat	345..381	CDD:293791	14/35 (40%)
		WD 3	382..421		18/38 (47%)
		WD40 repeat	388..418	CDD:293791	13/29 (45%)
		WD 4	424..463		19/38 (50%)
		WD40 repeat	429..465	CDD:293791	16/35 (46%)
		WD 5	466..505		14/38 (37%)
		WD40 repeat	471..507	CDD:293791	12/35 (34%)
		WD 6	508..547		9/40 (23%)
		WD40 repeat	513..537	CDD:293791	4/23 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0263
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19879
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910