Protein Alignment can and taf5

DIOPT Version :10

• Sequence 1: NP_524827.1
• Gene: can / 45432
• FlyBaseID: FBgn0011569
• Length: 942
• Species: Drosophila melanogaster
• Sequence 2: NP_001135586.1
• Gene: taf5 / 100216139
• XenbaseID: XB-GENE-1004611
• Length: 777
• Species: Xenopus tropicalis
• Alignment Length: 799
• Identity: 216/799 - (27%)
• Similarity: 353/799 - (44%)
• Gaps: 146/799 - (18%)

  Fly   152 PMPSMPIYDEETCQFEMVPPIIQPDLIKEVTDAEMPIE-LDKSDSE--------LEKEKLKADED 207
            |.||.|         :..||:  |..:.....|..|.. .|.||.:        |:|.|||...|
 Frog    43 PSPSSP---------QAAPPV--PPGVAAPPAAAAPAPGSDASDRQTLLAVLQYLKKRKLKDSAD 96

  Fly   208 DNFSDSNTSSSFSLSSLDDYDYGETDLDEQHNENKCTYWEEMSLRPVDKGEVSQEELMAILNEDE 272
                                                     :.||  :.|....:||:|:.:
 Frog    97 -----------------------------------------ILLR--ESGLFDSDELLALTS--- 115

  Fly   273 SSPDHRSECD-IDEAIRTR----DGSDF-------YEDSAQFL-----------ENMENVSLLVI 314
            .|||.....| .|..:.:|    .|||.       ...||...           ::..:||.::.
 Frog   116 LSPDRAGAGDGADTTLLSRVSGAAGSDISASAGGAASSSASSACAGKVTLNNGPQDQPDVSAVLS 180

  Fly   315 K-----EDSVFADYEFAVKKLIKLIQSTPSHYKYEIYILLYPLLVLTYLQMMASDKIQKARMLLV 374
            .     :.:::.:|...:|   :.|:|....::.|:..|.|||.|..||:::.:...|||:....
 Frog   181 AYTQQGDPALYEEYYSGLK---RFIESVLDCHRAELSQLFYPLFVHMYLELVYNQHEQKAKSFFE 242

  Fly   375 RFQDHLDDSYISRIIKLREISKPAEVPNKARKLLAGLEKVKIEMSEGAFRQLLLCTEE------W 433
            :|....:..|...:..|..:||...:......|.....|..:.:|..:::.|....:|      |
 Frog   243 KFHGDQECYYEDDLRILASLSKKGHMMGNETILDFRTSKFVLRISRDSYQLLKRHLQERQNNQIW 307

  Fly   434 TRGQQEKLLSHFQIQPYSEDDKPQQRFAI-----GQPLLE----PIWYG---APE---PLHKKDF 483
            :..|:...:..|...|.|:    ||..|:     |:...|    .|::|   .||   ||..:|.
 Frog   308 SIVQEHLYIDIFDGMPRSK----QQIDAMVGSLSGEAKREANKAKIFFGLLKEPEIEVPLDDEDE 368

  Fly   484 AARPFFQKRRKKRSEPQLSDNL---------HLPPVNRVYNPIP-----NKMDLLHMKSDEQYRM 534
            .......|.:||:.:   .||:         :.||.||:  |:|     :|:|.:.:..:...|:
 Frog   369 EVENEEGKPKKKKPK---KDNVGSKSKKQDPNAPPQNRI--PLPELKDSDKLDKIMIMKETAKRV 428

  Fly   535 KLDRNNLPSTYLYTTSPSDEVVICATFSEGNSMLALGTVSSKVYVFSLKPSKLVQVKAAQWLKNL 599
            :|.:::|||...||...:.:.:.....::.:|::|.|...|.|.|:||.|.||..||:|..|..:
 Frog   429 RLGQDSLPSICFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSLTPKKLRSVKSASDLSII 493

  Fly   600 DTGMAGVDKDMIDPIKKFTRRTLYGHQGPVYGCSFNPEDRFLITCSEDFSVRLWCLLSWSCVVIF 664
            |.....|.:.::|.......:.||||.||||..||:|:..:|::.|||.::|||.|.:::|:|.:
 Frog   494 DKESDDVLERIMDEKSSSEMKVLYGHSGPVYATSFSPDRNYLLSSSEDGTIRLWSLQTFTCLVAY 558

  Fly   665 SGHLAPVCFVVFAPRGYYFATASDDCTARVWMQDNTKPARILQGHLAELGVCLFHPNRHYMATGS 729
            .||..||....|:|.||||.:...|..||:|..|:.:|.||..||||::....||||.:|:||||
 Frog   559 KGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVICTRFHPNSNYIATGS 623

  Fly   730 ADCTVRIWDIVKAVQVRIFRGHKSRITALIYSICGRYLVSGGDDNLIMIWDTANEILMQFFDHHK 794
            .|.|||:||::....||||.|||..|.:|.::..|::|.:|..|..:::||..:.:::.....|.
 Frog   624 TDRTVRLWDVLNGNCVRIFTGHKGPIHSLAFTPNGKFLATGASDGRVLLWDIGHGLMVGELKGHT 688

  Fly   795 ASINTMEISLDNNILVVGGQDCQLTLWDFEQVIKNYLNRAKISMKNQAG--TQESSANNLLVSSF 857
            .::..:..|.|..||.....|..:.|||   .:|.:.:.......:.||  ....::.:||:.:|
 Frog   689 NTVYALRFSRDGEILSSVSMDNTVRLWD---TVKAFEDLDTDDFTSSAGHINFHENSQDLLLGTF 750

  Fly   858 FTKGEPFYMIRFTRRNLLL 876
            .||..|...:.||||||||
 Frog   751 MTKSTPVIHLHFTRRNLLL 769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
can	NP_524827.1	TAF5_NTD2	320..453	CDD:176269	30/138 (22%)
		WD40 repeat	591..624	CDD:293791	7/32 (22%)
		WD40	619..>823	CDD:238121	81/203 (40%)
		WD40 repeat	629..666	CDD:293791	15/36 (42%)
		WD40 repeat	672..708	CDD:293791	14/35 (40%)
		WD40 repeat	713..749	CDD:293791	18/35 (51%)
		WD40 repeat	760..790	CDD:293791	6/29 (21%)
taf5	NP_001135586.1	TAF5_NTD2	188..320	CDD:176269	27/134 (20%)
		WD40 repeat	450..507	CDD:293791	17/56 (30%)
		WD40	<451..717	CDD:441893	100/268 (37%)
		WD40 repeat	524..560	CDD:293791	14/35 (40%)
		WD40 repeat	565..601	CDD:293791	15/35 (43%)
		WD40 repeat	608..643	CDD:293791	18/34 (53%)
		WD40 repeat	649..685	CDD:293791	8/35 (23%)
		WD40 repeat	691..737	CDD:293791	11/48 (23%)