DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MTNR1A and tkr-3

DIOPT Version :9

Sequence 1:	NP_005949.1	Gene:	MTNR1A / 4543	HGNCID:	7463	Length:	350	Species:	Homo sapiens
Sequence 2:	NP_001343603.1	Gene:	tkr-3 / 177285	WormBaseID:	WBGene00006428	Length:	400	Species:	Caenorhabditis elegans

Alignment Length:	395	Identity:	99/395 - (25%)
Similarity:	170/395 - (43%)	Gaps:	71/395 - (17%)

- Green bases have known domain annotations that are detailed below.

Human     3 GNGSALPNASQPVLRGDG----ARPSWLASALACVLIFTIV-VDILGNLLVILSVYRNKKLRNAG 62
            |....|..|.:..|.||.    ..|..|  .:.|:|...|. :.::|||||:.......::|:..
Worm    19 GGAGVLAEAGEAELSGDDDFYELTPVEL--IIWCMLYAIIAFMAVVGNLLVLYITLFRLRVRSIT 81

Human    63 NIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYC 127
            ..|:::|..|||...|:..|....:.....|.|....|::..::..:::..|:|.:...|::.:
Worm    82 TYFILNLGFADLFTGIFAIPFKFQAALFQEWFLPRSLCRIVPYVETVALTVSVFTLVTSAVHEF- 145

Human   128 YICHSLKYDKL--YSSKNSLCYVLLIWLLTLAAVLPN-LRAGTLQYDPRIYSCTFAQSVS----- 184
               .::.:.|.  .|.:::...|||||::.:...||: |...|.:: |...:.:..|.:.
Worm   146 ---RTMFFSKCSQMSPRSAKRCVLLIWIMAVLVSLPHGLFHNTYEF-PDDNNTSIVQCLPVYPDA 206

Human   185 ---SAYTIAVVVFHFLVPMIIVIFCY----LRIWILVLQVRQRVKPDRKPKLKPQDF-------- 234
               ..|.:.:|:..:.|||||:...|    ::||.|   .:.||:.| :.|:..|..
Worm   207 GWWKTYNVYLVIIQYFVPMIILDTAYTMIAVKIWSL---SQSRVELD-ETKMATQKISVVSMVSP 267

Human   235 -----RNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEW-----LFVASYYMAYFNSC 289
                 :...|:.:|...|::||.||....|.     ..:.|.|..|     :|..|:::|..|||
Worm   268 NTQLSQLMRTLIIVVACFSLCWFPLETYLLL-----NELKPEINGWKYINLVFFFSHWLAMSNSC 327

Human   290 LNAIIYGLLNQNFRKEYRRII--VSLCTARVFFVD----------SSNDVADRVKWK-----PSP 337
            ||.|||||.|..:.:||||:.  :.....|...:|          ||||..|:.:..     |..
Worm   328 LNPIIYGLYNTKYNEEYRRLFRQIGCIWQRQKSLDDSMKPERRWNSSNDCQDQQEIDQIVDIPPV 392

Human   338 LMTNN 342
            :.|||
Worm   393 ISTNN 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MTNR1A	NP_005949.1	7tm_GPCRs	28..306	CDD:333717	76/311 (24%)
		TM helix 1	30..54	CDD:320095	8/24 (33%)
		TM helix 2	63..85	CDD:320095	7/21 (33%)
		TM helix 3	101..123	CDD:320095	2/21 (10%)
		TM helix 4	146..162	CDD:320095	6/15 (40%)
		TM helix 5	185..208	CDD:320095	8/26 (31%)
		TM helix 6	234..259	CDD:320095	7/37 (19%)
		TM helix 7	274..299	CDD:320095	14/29 (48%)
tkr-3	NP_001343603.1	7tm_GPCRs	47..344	CDD:391938	76/310 (25%)
		TM helix 1	48..74	CDD:341315	8/25 (32%)
		TM helix 2	81..106	CDD:341315	7/24 (29%)
		TM helix 3	119..149	CDD:341315	4/33 (12%)
		TM helix 4	160..181	CDD:341315	7/20 (35%)
		TM helix 5	209..238	CDD:341315	8/28 (29%)
		TM helix 6	254..299	CDD:341315	9/49 (18%)
		TM helix 7	312..337	CDD:341315	13/24 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910