DRSC/TRiP Functional Genomics Resources

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Protein Alignment MTNR1A and npr-15

DIOPT Version :9

Sequence 1:NP_005949.1 Gene:MTNR1A / 4543 HGNCID:7463 Length:350 Species:Homo sapiens
Sequence 2:NP_497744.2 Gene:npr-15 / 175470 WormBaseID:WBGene00012084 Length:345 Species:Caenorhabditis elegans


Alignment Length:336 Identity:80/336 - (23%)
Similarity:145/336 - (43%) Gaps:36/336 - (10%)


- Green bases have known domain annotations that are detailed below.


Human    32 CVLIFTIVVDILGNLLVILSVYRNKKLR-NAGNIFVVSLAVADLVVAIYPYPLVLMSIF--NNGW 93
            |..|...||.|:||::||.::..::.:| :..||.:::||||||...|:..|..:..:|  :..|
 Worm    11 CFFIILSVVGIIGNVIVIYAIAGDRNMRKSVMNILLLNLAVADLANLIFTIPEWIPPVFFGSTDW 75

Human    94 NLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAA 158
            ......|.|..:|..:.:..||.....:.|.||..|...::..:|.|.:|.|..||:.|:.....
 Worm    76 LFPSFLCPVCRYLECVFLFASISTQMIVCIERYIAIVLPMQARQLCSRRNVLITVLVDWIFVACF 140

Human   159 VLP----------NLRAGTLQYDPRIYSCTFAQSVSSA-----YTIAVVVFHFLVPMIIVIFCYL 208
            ..|          :....:|::.....|.|.:.:|..:     |.:...:..:.||..|:...|.
 Worm   141 ASPYAVWHSVKTKDRNTNSLRFKLFQLSATCSNTVGKSTWWQGYKLTEFLAFYFVPCFIITVVYT 205

Human   209 RI----WIL--VLQVRQRVKPDRKPKLKPQDF----RNFVTMFVVFV-LFAICWAPLNFIGLAVA 262
            ::    |..  .||...|...|.|...:..|.    ||.|.|.:..| ::.:|::|:..|.|:.|
 Worm   206 KVAKCLWCKDPTLQCETRSCLDNKSSSRSSDALRTRRNVVKMLIACVAVYFVCYSPIQVIFLSKA 270

Human   263 SDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRII-----VSLCTARVFFVD 322
            ....::.|  |....:....:|...|..|.::|.|.:|.||:..|.::     |...|...:.::
 Worm   271 VLNVTIHP--PYDFILLMNALAMTCSASNPLLYTLFSQKFRRRLRDVLYCPSDVENETKTYYSIN 333

Human   323 SSNDVADRVKW 333
            :::.|..|..:
 Worm   334 NTSIVGPRASF 344

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MTNR1ANP_005949.1 7tm_GPCRs 28..306 CDD:333717 75/302 (25%)
TM helix 1 30..54 CDD:320095 9/21 (43%)
TM helix 2 63..85 CDD:320095 10/21 (48%)
TM helix 3 101..123 CDD:320095 4/21 (19%)
TM helix 4 146..162 CDD:320095 4/25 (16%)
TM helix 5 185..208 CDD:320095 4/27 (15%)
TM helix 6 234..259 CDD:320095 8/29 (28%)
TM helix 7 274..299 CDD:320095 5/24 (21%)
npr-15NP_497744.2 7tm_4 17..>156 CDD:304433 37/138 (27%)
7tm_1 23..301 CDD:278431 65/279 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24228
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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