Protein Alignment MYO1F and MYO5

DIOPT Version :9

• Sequence 1: XP_011526326.1
• Gene: MYO1F / 4542
• HGNCID: 7600
• Length: 1119
• Species: Homo sapiens
• Sequence 2: NP_013827.1
• Gene: MYO5 / 855136
• SGDID: S000004715
• Length: 1219
• Species: Saccharomyces cerevisiae
• Alignment Length: 1209
• Identity: 460/1209 - (38%)
• Similarity: 668/1209 - (55%)
• Gaps: 165/1209 - (13%)

Human     2 GSKERFHWQ----SHNVKQS----------GVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGS 52
            |::::.|.:    |.|:|::          ||.|:.||.:|:::||..||:|||::..|:||||.
Yeast     7 GARKKVHQEPAKRSANIKKATFDSSKKKEVGVSDLTLLSKISDEAINENLKKRFLNATIYTYIGH 71

Human    53 VLISVNPFKQMPYFTDREIDLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKT 117
            ||||||||:.:..:||..::.|:|..:.|.|||::|:.::||.||....||||||||||||||||
Yeast    72 VLISVNPFRDLGIYTDAVMNEYKGKNRLEVPPHVFAIAESMYYNMKSYNENQCVIISGESGAGKT 136

Human   118 VAAKYIMGYISKVSG-GGEKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGE 181
            .|||.||.||:..|. ..|.:..:||::|.:|||||:||.|||:|||||||.|||.||:|:...|
Yeast   137 EAAKRIMQYIAAASSTHTESIGKIKDMVLATNPLLESFGCAKTLRNNNSSRHGKYLEIKFNNQFE 201

Human   182 PDGGKISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSDTYQVDG 246
            |..|.|:|:||||.|||.|.:|||||||:||..:|||...||..|:..|:.|.|...:.....:.
Yeast   202 PCAGNITNYLLEKQRVVSQIKNERNFHIFYQFTKGASDAYRQTFGVQKPEQYVYTAAAGCISAET 266

Human   247 TDDRSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFC--EDGNYARVESVDLLAFPAYL 309
            .||..|:.|||.||:|||:....|..:.:::|.||.:||:||.  |:|| |:|....:..|.|||
Yeast   267 IDDLQDYQETLKAMRVIGLGQEEQDQIFRMLAAILWIGNVSFIENEEGN-AQVRDTSVTDFVAYL 330

Human   310 LGIDSGRLQEKLTSRKMDSRWGGRSESI-NVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRAM 373
            |.|||..|.:.|..|.|::..|.:..|: :|.||:.||...||||||.:|..|||::|..:|:::
Yeast   331 LQIDSQLLIKSLVERIMETNHGMKRGSVYHVPLNIVQADAVRDALAKAIYNNLFDWIVSRVNKSL 395

Human   374 QK-PQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIQ 437
            |. |..|.|||:|||||||||:.|.|||.|||:||||||||||:||||:|||.|.:|.|:||||:
Yeast   396 QAFPGAEKSIGILDIYGFEIFEHNSFEQICINYVNEKLQQIFIQLTLKSEQETYEREKIQWTPIK 460

Human   438 YFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLLQKLQAAVGTHEHFNSWSAGFVI 502
            ||:|||||||||.: .||||.:.::|..||.||....|||...|:|.... |:.||:..|..|||
Yeast   461 YFDNKVVCDLIEAR-RPPGIFAAMNDSVATAHADSNAADQAFAQRLNLFT-TNPHFDLRSNKFVI 523

Human   503 HHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQAFLRMLFPEKLDGDKKGRPSTAGSKIKKQA 567
            .||||.|:||:.|..::|:|.|..||:||:.|:...||..:||:.:|.:.|.||.|||.||.|.|
Yeast   524 KHYAGDVTYDIDGITDKNKDQLQKDLVELIGTTTNTFLATIFPDTVDRESKRRPPTAGDKIIKSA 588

Human   568 NDLVATLMRCTPHYIRCIKPNETKRPRDWEENRTGDSPPRGDSAYPPHQSQAPGGIPGPEGEHQG 632
            ||||.||.:..|.|||.|||||||.|.|:::.:.            .||.           ::.|
Yeast   589 NDLVETLSKAQPSYIRTIKPNETKSPNDYDDRQV------------LHQI-----------KYLG 630

Human   633 AQSRLRLPP---PVRQIPAEPSALRYAILTPE-------TWPRWRGDERQGVQHLLRAVNMEPDQ 687
            .|..:|:..   ..||: .|....|:.:|:|.       |   |:||....|:::|:..::...:
Yeast   631 LQENVRIRRAGFAYRQV-FEKFVERFYLLSPHCSYAGDYT---WQGDTLDAVKYILQDSSIPQQE 691

Human   688 YQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQKAWRRHVAVR------------------KY 734
            ||:|.|.||:|.||:||.||.:|:|.:...|..||:||||.:..|                  ||
Yeast   692 YQLGVTSVFIKTPETLFALEHMRDRYWHNMAARIQRAWRRFLQRRIDAATKIQRTIRERKEGNKY 756

Human   735 EEMREEASNILLNKKERRRNSI--NRNFVGDYLGLEERPE----LRQFLGKRERVDFA---DSV- 789
            |::|:..:.:|..:||||..|:  .|.|:||||...|...    :::.:..:|:|.|:   :::
Yeast   757 EKLRDYGTKVLGGRKERRSMSLLGYRAFMGDYLSCNESKSKGAYIKRQVSIKEKVIFSIHGEALH 821

Human   790 TKYDRRFKPIKRDLILTPKCVYVIGREKVKKGPEKGQVCEVLKKKVDIQALRGVSLSTRQDDFFI 854
            ||:.|..:.:|:..:|||..:|::|:..|:......|     ..|:|::.::.|||:..|||:..
Yeast   822 TKFGRSAQRLKKTFLLTPTTLYIVGQTLVQNAMTYTQ-----DYKIDVRNIQAVSLTNLQDDWVA 881

Human   855 LQ---EDAADSFLESVFKTEFVSLLCKRFEEATRRPLPLTFSDTLQFRVKKEGWGGGGTRSV--- 913
            ::   ....|..:.:.||||.::.| ||..:    .:.:.....::::.|.     |...||
Yeast   882 IKLASSGQPDPLINTYFKTELITHL-KRLND----KIQIKIGSAIEYQKKP-----GKLHSVKCQ 936

Human   914 --TFSRGFGDLAVLKVGGRTLTVSVGDGLPKSS----KPTRK-GMAKGKPRRSSQAPTR------ 965
              ..:..:||:.      ::.|:||..|.|.:|    ||.:| .::.|....||||..|
Yeast   937 INESAPKYGDIY------KSSTISVRRGNPPNSQVHKKPRKKSSISSGYHASSSQATRRPVSIAA 995

Human   966 -----AAPA---------PPRGMDRNGVPPSARGGPLPLEIMSGGGTHRPPRGPPSTSLGASRRP 1016
                 .|||         ||.||.....  :.|..|.|...::...::..| .||:.:      .
Yeast   996 AQHVPTAPASRHSKKPAPPPPGMQNKAA--TRRSVPNPASTLTASQSNARP-SPPTAA------T 1051

Human  1017 RARPPSEHNTEFLNVPDQGMAGMQRKRSVGQRPVPGVGRPKPQPRTHGPRCRALYQYVGQ-DVDE 1080
            ||.|.:        .|.....|..|:.::...|.|    |.|..:...|...|.|.:.|. ...|
Yeast  1052 RATPAA--------TPAAAAMGSGRQANIPPPPPP----PPPSSKPKEPMFEAAYDFPGSGSPSE 1104

Human  1081 LSFNVNEVIEILMEDPSGWWKGRL--HGQEGLFPGNYVE 1117
            |.....:||.|..|:||||..|:|  ..:||..|..|::
Yeast  1105 LPLKKGDVIYITREEPSGWSLGKLLDGSKEGWVPTAYMK 1143

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO1F	XP_011526326.1	MYSc	12..711	CDD:214580	336/723 (46%)
		MYSc_Myo1	31..698	CDD:276829	321/681 (47%)
		Myosin_TH1	738..918	CDD:283635	48/197 (24%)
		SH3_MyoIe_If_like	1066..1118	CDD:212761	19/55 (35%)
MYO5	NP_013827.1	COG5022	1..1186	CDD:227355	460/1209 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	643	1.000	Domainoid score	I21
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56276
Inparanoid	1	1.050	774	1.000	Inparanoid score	I72
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	1	1.000	-	-		mtm10096
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	1	1.100	-	-	LDO	PTHR13140
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2201
SonicParanoid	1	1.000	-	-		X1588
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.990