Protein Alignment MYO1F and Myo31DF

DIOPT Version :10

• Sequence 1: NP_001427538.1
• Gene: MYO1F / 4542
• HGNCID: 7600
• Length: 1119
• Species: Homo sapiens
• Sequence 2: NP_523538.1
• Gene: Myo31DF / 34445
• FlyBaseID: FBgn0086347
• Length: 1011
• Species: Drosophila melanogaster
• Alignment Length: 1032
• Identity: 342/1032 - (33%)
• Similarity: 509/1032 - (49%)
• Gaps: 186/1032 - (18%)

Human    15 KQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREIDLYQGAAQ 79
            :::||.|.|||.|::.:....||||||.:..|:||||.|.:|:||::||..:....|..|:|...
  Fly     5 REAGVQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGREL 69

Human    80 YENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSG--GGEKVQHVKD 142
            :||.||::|:.|:.||.:....::.|::||||||||||.|:|.||.||:.|:.  |..:::.||:
  Fly    70 FENAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKN 134

Human   143 IILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVMQNENERNF 207
            :::|||.:||.||||||.||:||||||||.:|:|....:|.||.|:|:||||||||.|...||||
  Fly   135 VLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNF 199

Human   208 HIYYQLLEGASQEQRQNLGLM-TPDYYYYLNQSDTYQVDGTDDRSDFGETLSAMQVIGIPPSIQQ 271
            |.:||||.||:..:.:...|. ....|:||||.   .:|...::||:..|.:|.:.:|......|
  Fly   200 HSFYQLLRGANDNELRQYELQKETGKYHYLNQG---SMDILTEKSDYKGTCNAFKTLGFSTDEVQ 261

Human   272 LVLQLVAGILHLGNISFCEDGNYARVESVDLLAFPAYLLGIDSGRLQEKLTSRKMDSRWGGRSES 336
            .:.:.:|.:|||||:.|....:...:.:...|...|.||.:....|...||.|.:.:  ||
  Fly   262 TIWRTIAAVLHLGNVEFQTIEDELVISNKQHLKSTAKLLQVTETELSTALTKRVIAA--GG---- 320

Human   337 INVTL---NVEQAAYTRDALAKGLYARLFDFLVEAINRAM----QKPQEEYS--IGVLDIYGFEI 392
             ||..   |..||.|.:|||||.:|.|||.:::..||||:    .|.|..::  |||||||||||
  Fly   321 -NVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGFEI 384

Human   393 FQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIQYFNNKVVCDLIENKLSPPGI 457
            |..|.|||||||:.||||||:||||.||.|||||.:|||.||.|:|||||::|||:|.  ...||
  Fly   385 FDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQ--PHKGI 447

Human   458 MSVLDDVCATMHATGGGADQTLLQKLQAAVGTHEHFNS-----------WSAGFVIHHYAGKVSY 511
            ::::|:.|.::   |...|.|||..:...:..|.|:.|           ....|.|.||||.|.|
  Fly   448 IAIMDEACLSV---GKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIY 509

Human   512 DVSGFCERNRDVLFSDLIELMQTSEQAFLRMLFPEKLDGDKK--GRPSTAGSKIKKQANDLVATL 574
            :::||.|:|:|.|:.|...|:..|:.|.|..::||.....||  .||.|||:..::...|||.||
  Fly   510 NINGFIEKNKDTLYQDFKRLLHNSKDANLSEMWPEGAQDIKKTTKRPLTAGTLFQRSMADLVVTL 574

Human   575 MRCTPHYIRCIKPNETKRPRDWEENRTGDSPPRGDSAYPPHQSQAPGGIPGPEGEHQGAQSRLRL 639
            ::..|.|:||||||:.|....::|.|.            .||.:..|.:........|...|.|.
  Fly   575 LKKEPFYVRCIKPNDLKSSTVFDEERV------------EHQVRYLGLLENLRVRRAGFVHRQRY 627

Human   640 PPPVRQIPAEPSALRYAILTPETWPRWR-GDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESL 703
                     :...|||.:::..|||.:| |.:|.||:.|:.......| .:.|.||:|:::|.:|
  Fly   628 ---------DKFLLRYKMISQYTWPNFRAGSDRDGVRVLIEEKKFAQD-VKYGHTKIFIRSPRTL 682

Human   704 FLLEEVRERKFDGFARTIQKAWRRHVAVRKYEEMR------------------EEASNILLNKKE 750
            |.||..|..........:||..|..:..|.:::|:                  :|.:|.|...|:
  Fly   683 FALEHQRNEMIPHIVTLLQKRVRGWIVRRNFKKMKAAITIVRAYKAYKLRSYVQELANRLRKAKQ 747

Human   751 R------------------------------RRNSI----------------------------- 756
            .                              |.|.|
  Fly   748 MRDYGKSIQWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPRSEWPQLRLQIIAATALAGRRPYW 812

Human   757 --NRNFVGDYL-GLEERPELRQFLGK-------------RERVDFADSVTKYDRRFKPIKRDLIL 805
              .|.:||||| ..:|......:.|.             .::|.|:..|.|::...|...|..|:
  Fly   813 GQARRWVGDYLANSQENSGYEAYNGSIKNIRNHPADGETFQQVLFSSFVKKFNHFNKQANRAFIV 877

Human   806 TPKCVYVIG--REKVKKGPEKGQVCEVLKKKVDIQALRGVSLSTRQDDFFIL----QEDAADSFL 864
            :...::.:.  :.|.|.          :|:.:.|:.|..:|:|..:|...:.    .:|...| |
  Fly   878 SDSTIHKLDGIKNKFKD----------MKRTIKIRELTSISVSPGRDQLIVFHSSKNKDLVFS-L 931

Human   865 ESVFKT-------EFVSLLCKRFEEATRRPLPLTFSDTLQFRVKKEGWGGGGTRSVT 914
            ||.:..       |.|.::||::.:.|...|.:..:..:..|:      .|..|.:|
  Fly   932 ESEYTPLKEDRIGEVVGIVCKKYHDLTGTELRVNVTTNISCRL------DGKARIIT 982

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYO1F	NP_001427538.1	None
Myo31DF	NP_523538.1	MYSc_Myo1	21..677	CDD:276829	279/692 (40%)
		Myosin_TH1	801..977	CDD:461801	35/192 (18%)