DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYO1F and Myo31DF

DIOPT Version :9

Sequence 1:	XP_011526326.1	Gene:	MYO1F / 4542	HGNCID:	7600	Length:	1119	Species:	Homo sapiens
Sequence 2:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster

Alignment Length:	1032	Identity:	342/1032 - (33%)
Similarity:	509/1032 - (49%)	Gaps:	186/1032 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    15 KQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREIDLYQGAAQ 79
            :::||.|.|||.|::.:....||||||.:..|:||||.|.:|:||::||..:....|..|:|...
  Fly     5 REAGVQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGREL 69

Human    80 YENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSG--GGEKVQHVKD 142
            :||.||::|:.|:.||.:....::.|::||||||||||.|:|.||.||:.|:.  |..:::.||:
  Fly    70 FENAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKN 134

Human   143 IILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVMQNENERNF 207
            :::|||.:||.||||||.||:||||||||.:|:|....:|.||.|:|:||||||||.|...||||
  Fly   135 VLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNF 199

Human   208 HIYYQLLEGASQEQRQNLGLM-TPDYYYYLNQSDTYQVDGTDDRSDFGETLSAMQVIGIPPSIQQ 271
            |.:||||.||:..:.:...|. ....|:||||.   .:|...::||:..|.:|.:.:|......|
  Fly   200 HSFYQLLRGANDNELRQYELQKETGKYHYLNQG---SMDILTEKSDYKGTCNAFKTLGFSTDEVQ 261

Human   272 LVLQLVAGILHLGNISFCEDGNYARVESVDLLAFPAYLLGIDSGRLQEKLTSRKMDSRWGGRSES 336
            .:.:.:|.:|||||:.|....:...:.:...|...|.||.:....|...||.|.:.:  ||
  Fly   262 TIWRTIAAVLHLGNVEFQTIEDELVISNKQHLKSTAKLLQVTETELSTALTKRVIAA--GG---- 320

Human   337 INVTL---NVEQAAYTRDALAKGLYARLFDFLVEAINRAM----QKPQEEYS--IGVLDIYGFEI 392
             ||..   |..||.|.:|||||.:|.|||.:::..||||:    .|.|..::  |||||||||||
  Fly   321 -NVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGFEI 384

Human   393 FQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIQYFNNKVVCDLIENKLSPPGI 457
            |..|.|||||||:.||||||:||||.||.|||||.:|||.||.|:|||||::|||:|.  ...||
  Fly   385 FDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQ--PHKGI 447

Human   458 MSVLDDVCATMHATGGGADQTLLQKLQAAVGTHEHFNS-----------WSAGFVIHHYAGKVSY 511
            ::::|:.|.::   |...|.|||..:...:..|.|:.|           ....|.|.||||.|.|
  Fly   448 IAIMDEACLSV---GKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIY 509

Human   512 DVSGFCERNRDVLFSDLIELMQTSEQAFLRMLFPEKLDGDKK--GRPSTAGSKIKKQANDLVATL 574
            :::||.|:|:|.|:.|...|:..|:.|.|..::||.....||  .||.|||:..::...|||.||
  Fly   510 NINGFIEKNKDTLYQDFKRLLHNSKDANLSEMWPEGAQDIKKTTKRPLTAGTLFQRSMADLVVTL 574

Human   575 MRCTPHYIRCIKPNETKRPRDWEENRTGDSPPRGDSAYPPHQSQAPGGIPGPEGEHQGAQSRLRL 639
            ::..|.|:||||||:.|....::|.|.            .||.:..|.:........|...|.|.
  Fly   575 LKKEPFYVRCIKPNDLKSSTVFDEERV------------EHQVRYLGLLENLRVRRAGFVHRQRY 627

Human   640 PPPVRQIPAEPSALRYAILTPETWPRWR-GDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESL 703
                     :...|||.:::..|||.:| |.:|.||:.|:.......| .:.|.||:|:::|.:|
  Fly   628 ---------DKFLLRYKMISQYTWPNFRAGSDRDGVRVLIEEKKFAQD-VKYGHTKIFIRSPRTL 682

Human   704 FLLEEVRERKFDGFARTIQKAWRRHVAVRKYEEMR------------------EEASNILLNKKE 750
            |.||..|..........:||..|..:..|.:::|:                  :|.:|.|...|:
  Fly   683 FALEHQRNEMIPHIVTLLQKRVRGWIVRRNFKKMKAAITIVRAYKAYKLRSYVQELANRLRKAKQ 747

Human   751 R------------------------------RRNSI----------------------------- 756
            .                              |.|.|
  Fly   748 MRDYGKSIQWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPRSEWPQLRLQIIAATALAGRRPYW 812

Human   757 --NRNFVGDYL-GLEERPELRQFLGK-------------RERVDFADSVTKYDRRFKPIKRDLIL 805
              .|.:||||| ..:|......:.|.             .::|.|:..|.|::...|...|..|:
  Fly   813 GQARRWVGDYLANSQENSGYEAYNGSIKNIRNHPADGETFQQVLFSSFVKKFNHFNKQANRAFIV 877

Human   806 TPKCVYVIG--REKVKKGPEKGQVCEVLKKKVDIQALRGVSLSTRQDDFFIL----QEDAADSFL 864
            :...::.:.  :.|.|.          :|:.:.|:.|..:|:|..:|...:.    .:|...| |
  Fly   878 SDSTIHKLDGIKNKFKD----------MKRTIKIRELTSISVSPGRDQLIVFHSSKNKDLVFS-L 931

Human   865 ESVFKT-------EFVSLLCKRFEEATRRPLPLTFSDTLQFRVKKEGWGGGGTRSVT 914
            ||.:..       |.|.::||::.:.|...|.:..:..:..|:      .|..|.:|
  Fly   932 ESEYTPLKEDRIGEVVGIVCKKYHDLTGTELRVNVTTNISCRL------DGKARIIT 982

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYO1F	XP_011526326.1	MYSc	12..711	CDD:214580	291/721 (40%)
		MYSc_Myo1	31..698	CDD:276829	279/692 (40%)
		Myosin_TH1	738..918	CDD:283635	45/283 (16%)
		SH3_MyoIe_If_like	1066..1118	CDD:212761
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	291/720 (40%)
		MYSc_Myo1	21..677	CDD:276829	279/692 (40%)
		Myosin_TH1	801..983	CDD:283635	38/199 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2201
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850