DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TrpRS and WARS1

DIOPT Version :9

Sequence 1:	NP_524826.1	Gene:	TrpRS / 45399	FlyBaseID:	FBgn0010803	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_004175.2	Gene:	WARS1 / 7453	HGNCID:	12729	Length:	471	Species:	Homo sapiens

Alignment Length:	427	Identity:	262/427 - (61%)
Similarity:	326/427 - (76%)	Gaps:	16/427 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DTKETVVEGVEALTLNGKPDAEPVETGTDAQAQEGATAPTEDVVDPWNVASSNDAGVDYDKLIKR 67
            |.|.....|..|.|.|..|||      |:|:         ||.||||.|.:|:..|:||||||.|
Human    57 DYKADCPPGNPAPTSNHGPDA------TEAE---------EDFVDPWTVQTSSAKGIDYDKLIVR 106

  Fly    68 FGSSKIDEELIARFEKITGKPAHHFIRRGMFFSHRDLHTILTLREQGKPFYLYTGRGPSSGSLHV 132
            |||||||:|||.|.|:.||:..|||:|||:||||||::.:|...|..|||||||||||||.::||
Human   107 FGSSKIDKELINRIERATGQRPHHFLRRGIFFSHRDMNQVLDAYENKKPFYLYTGRGPSSEAMHV 171

  Fly   133 GHLVPFIMTKWLQETFDVPLVIQLTDDEKTLWKDLKVEDAIKLGRENAKDIVAIGFDVNKTFIFN 197
            |||:|||.|||||:.|:||||||:|||||.|||||.::.|.....||||||:|.|||:||||||:
Human   172 GHLIPFIFTKWLQDVFNVPLVIQMTDDEKYLWKDLTLDQAYSYAVENAKDIIACGFDINKTFIFS 236

  Fly   198 NLEFVGKCPAMYQNIIRIQKCVTFNQVKGIFGFGDSDIIGKIGFPAAQAAPAISSTFPFIFGNR- 261
            :|:::|.....|:|:::|||.||||||||||||.|||.||||.|||.||||:.|::||.||.:|
Human   237 DLDYMGMSSGFYKNVVKIQKHVTFNQVKGIFGFTDSDCIGKISFPAIQAAPSFSNSFPQIFRDRT 301

  Fly   262 KVHCLIPCAIDQDPYFRMTRDVAPRLGFPKCALIHSTFFPALQGAKTKMSASDQNSAVYLTDTPK 326
            .:.||||||||||||||||||||||:|:||.||:|||||||||||:|||||||.||:::||||.|
Human   302 DIQCLIPCAIDQDPYFRMTRDVAPRIGYPKPALLHSTFFPALQGAQTKMSASDPNSSIFLTDTAK 366

  Fly   327 QIKNKINKYAFSGGRVSVEEHRKLGGVPEVDVSYQLLKFFLEDDAKLEEVRVAYSKGEMLTGEIK 391
            |||.|:||:||||||.::||||:.||..:||||:..|.||||||.|||::|..|:.|.|||||:|
Human   367 QIKTKVNKHAFSGGRDTIEEHRQFGGNCDVDVSFMYLTFFLEDDDKLEQIRKDYTSGAMLTGELK 431

  Fly   392 KLAVETLTPIVEQHQAARKLITDEVLDKYFELRPLKF 428
            |..:|.|.|::.:|||.||.:|||::.::...|.|.|
Human   432 KALIEVLQPLIAEHQARRKEVTDEIVKEFMTPRKLSF 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TrpRS	NP_524826.1	PLN02486	45..426	CDD:178104	247/381 (65%)
TrpRS	NP_524826.1	trpS	115..422	CDD:272975	204/307 (66%)
WARS1	NP_004175.2	WEPRS_RNA	12..61	CDD:238473	2/3 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..79		8/25 (32%)
		PLN02486	85..466	CDD:178104	247/380 (65%)
		'HIGH' region	164..173		5/8 (63%)
		'KMSKS' region	349..353		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148046
Domainoid	1	1.000	411	1.000	Domainoid score	I679
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3084
Inparanoid	1	1.050	535	1.000	Inparanoid score	I1204
Isobase	1	0.950	-	0	Normalized mean entropy	S449
OMA	1	1.010	-	-		QHG62151
OrthoDB	1	1.010	-	-		D300066at33208
OrthoFinder	1	1.000	-	-		FOG0003947
OrthoInspector	1	1.000	-	-		oto89497
orthoMCL	1	0.900	-	-		OOG6_101168
Panther	1	1.100	-	-	LDO	PTHR10055
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1459
SonicParanoid	1	1.000	-	-		X3247
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.890