Protein Alignment TrpRS and WARS1

DIOPT Version :10

• Sequence 1: NP_524826.1
• Gene: TrpRS / 45399
• FlyBaseID: FBgn0010803
• Length: 430
• Species: Drosophila melanogaster
• Sequence 2: NP_004175.2
• Gene: WARS1 / 7453
• HGNCID: 12729
• Length: 471
• Species: Homo sapiens
• Alignment Length: 427
• Identity: 262/427 - (61%)
• Similarity: 326/427 - (76%)
• Gaps: 16/427 - (3%)

  Fly     3 DTKETVVEGVEALTLNGKPDAEPVETGTDAQAQEGATAPTEDVVDPWNVASSNDAGVDYDKLIKR 67
            |.|.....|..|.|.|..|||      |:|:         ||.||||.|.:|:..|:||||||.|
Human    57 DYKADCPPGNPAPTSNHGPDA------TEAE---------EDFVDPWTVQTSSAKGIDYDKLIVR 106

  Fly    68 FGSSKIDEELIARFEKITGKPAHHFIRRGMFFSHRDLHTILTLREQGKPFYLYTGRGPSSGSLHV 132
            |||||||:|||.|.|:.||:..|||:|||:||||||::.:|...|..|||||||||||||.::||
Human   107 FGSSKIDKELINRIERATGQRPHHFLRRGIFFSHRDMNQVLDAYENKKPFYLYTGRGPSSEAMHV 171

  Fly   133 GHLVPFIMTKWLQETFDVPLVIQLTDDEKTLWKDLKVEDAIKLGRENAKDIVAIGFDVNKTFIFN 197
            |||:|||.|||||:.|:||||||:|||||.|||||.::.|.....||||||:|.|||:||||||:
Human   172 GHLIPFIFTKWLQDVFNVPLVIQMTDDEKYLWKDLTLDQAYSYAVENAKDIIACGFDINKTFIFS 236

  Fly   198 NLEFVGKCPAMYQNIIRIQKCVTFNQVKGIFGFGDSDIIGKIGFPAAQAAPAISSTFPFIFGNR- 261
            :|:::|.....|:|:::|||.||||||||||||.|||.||||.|||.||||:.|::||.||.:|
Human   237 DLDYMGMSSGFYKNVVKIQKHVTFNQVKGIFGFTDSDCIGKISFPAIQAAPSFSNSFPQIFRDRT 301

  Fly   262 KVHCLIPCAIDQDPYFRMTRDVAPRLGFPKCALIHSTFFPALQGAKTKMSASDQNSAVYLTDTPK 326
            .:.||||||||||||||||||||||:|:||.||:|||||||||||:|||||||.||:::||||.|
Human   302 DIQCLIPCAIDQDPYFRMTRDVAPRIGYPKPALLHSTFFPALQGAQTKMSASDPNSSIFLTDTAK 366

  Fly   327 QIKNKINKYAFSGGRVSVEEHRKLGGVPEVDVSYQLLKFFLEDDAKLEEVRVAYSKGEMLTGEIK 391
            |||.|:||:||||||.::||||:.||..:||||:..|.||||||.|||::|..|:.|.|||||:|
Human   367 QIKTKVNKHAFSGGRDTIEEHRQFGGNCDVDVSFMYLTFFLEDDDKLEQIRKDYTSGAMLTGELK 431

  Fly   392 KLAVETLTPIVEQHQAARKLITDEVLDKYFELRPLKF 428
            |..:|.|.|::.:|||.||.:|||::.::...|.|.|
Human   432 KALIEVLQPLIAEHQARRKEVTDEIVKEFMTPRKLSF 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TrpRS	NP_524826.1	PLN02486	45..426	CDD:178104	247/381 (65%)
WARS1	NP_004175.2	WEPRS_RNA	12..61	CDD:238473	2/3 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	59..79		8/25 (32%)
		PLN02486	85..466	CDD:178104	247/380 (65%)
		'HIGH' region. /evidence=ECO:0000269|PubMed:1373391	164..173		5/8 (63%)
		'KMSKS' region. /evidence=ECO:0000269|PubMed:1373391	349..353		3/3 (100%)