DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TrpRS and Wars1

DIOPT Version :9

Sequence 1:	NP_524826.1	Gene:	TrpRS / 45399	FlyBaseID:	FBgn0010803	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_001013188.2	Gene:	Wars1 / 314442	RGDID:	1308278	Length:	475	Species:	Rattus norvegicus

Alignment Length:	412	Identity:	258/412 - (62%)
Similarity:	318/412 - (77%)	Gaps:	16/412 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NGKPDAEPVETGTDAQAQEGATAPTEDVVDPWNVASSNDAGVDYDKLIKRFGSSKIDEELIARFE 82
            ||.||               ||..:||.||||.|.:|:..|:||||||.:|||||||:|||.|.|
  Rat    76 NGDPD---------------ATKASEDFVDPWTVRTSSAKGIDYDKLIVQFGSSKIDKELINRIE 125

  Fly    83 KITGKPAHHFIRRGMFFSHRDLHTILTLREQGKPFYLYTGRGPSSGSLHVGHLVPFIMTKWLQET 147
            :.||:..|.|:|||:||||||::.||...|..|||||||||||||.::|:|||||||.|||||:.
  Rat   126 RATGQRPHRFLRRGIFFSHRDMNQILDAYENKKPFYLYTGRGPSSEAMHLGHLVPFIFTKWLQDV 190

  Fly   148 FDVPLVIQLTDDEKTLWKDLKVEDAIKLGRENAKDIVAIGFDVNKTFIFNNLEFVGKCPAMYQNI 212
            ||||||||::||||.|||||.:|.|.....||||||:|.||||||||||::||::|:.|..|:|:
  Rat   191 FDVPLVIQMSDDEKYLWKDLTLEQAYSYTVENAKDIIACGFDVNKTFIFSDLEYMGQSPGFYKNV 255

  Fly   213 IRIQKCVTFNQVKGIFGFGDSDIIGKIGFPAAQAAPAISSTFPFIFGNR-KVHCLIPCAIDQDPY 276
            ::|||.||||||||||||.|||.||||.|||.||||:.|::||.||.:| .:.||||||||||||
  Rat   256 VKIQKHVTFNQVKGIFGFTDSDCIGKISFPAVQAAPSFSNSFPKIFRDRTDIQCLIPCAIDQDPY 320

  Fly   277 FRMTRDVAPRLGFPKCALIHSTFFPALQGAKTKMSASDQNSAVYLTDTPKQIKNKINKYAFSGGR 341
            ||||||||||:|.||.||:|||||||||||:|||||||.||:::||||.||||:|:||:|||||.
  Rat   321 FRMTRDVAPRIGHPKPALLHSTFFPALQGAQTKMSASDPNSSIFLTDTAKQIKSKVNKHAFSGGS 385

  Fly   342 VSVEEHRKLGGVPEVDVSYQLLKFFLEDDAKLEEVRVAYSKGEMLTGEIKKLAVETLTPIVEQHQ 406
            .:|||||:.||..|||||:..|.||||||..||::|..|:.|.|||||:||..::.|.|::.:||
  Rat   386 DTVEEHRQFGGNCEVDVSFMYLTFFLEDDDSLEQIRKDYTSGAMLTGELKKTLIDVLQPLIAEHQ 450

  Fly   407 AARKLITDEVLDKYFELRPLKF 428
            |.||.:|:|.:.::...|.|.|
  Rat   451 ARRKAVTEETVKEFMAPRQLSF 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TrpRS	NP_524826.1	PLN02486	45..426	CDD:178104	248/381 (65%)
TrpRS	NP_524826.1	trpS	115..422	CDD:272975	206/307 (67%)
Wars1	NP_001013188.2	WHEP-TRS	16..68	CDD:278865
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..85		6/23 (26%)
		PLN02486	89..470	CDD:178104	248/380 (65%)
		trpS	158..467	CDD:272975	206/308 (67%)
		'HIGH' region	168..177		4/8 (50%)
		'KMSKS' region	353..357		3/3 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341921
Domainoid	1	1.000	415	1.000	Domainoid score	I645
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3084
Inparanoid	1	1.050	533	1.000	Inparanoid score	I1170
OMA	1	1.010	-	-		QHG62151
OrthoDB	1	1.010	-	-		D300066at33208
OrthoFinder	1	1.000	-	-		FOG0003947
OrthoInspector	1	1.000	-	-		oto96621
orthoMCL	1	0.900	-	-		OOG6_101168
Panther	1	1.100	-	-	LDO	PTHR10055
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3247
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910