DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TrpRS and wrs1

DIOPT Version :9

Sequence 1:	NP_524826.1	Gene:	TrpRS / 45399	FlyBaseID:	FBgn0010803	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_592983.1	Gene:	wrs1 / 2541841	PomBaseID:	SPAC2F7.13c	Length:	395	Species:	Schizosaccharomyces pombe

Alignment Length:	386	Identity:	218/386 - (56%)
Similarity:	279/386 - (72%)	Gaps:	8/386 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 EDVVDPWNVASS----NDAGVDYDKLIKRFGSSKIDEELIARFEKITGKPAHHFIRRGMFFSHRD 103
            |.:|.||:|..|    .:.|:||::||.:||:.||..|.:.||||:|||..|..:|||.||||||
pombe     5 EQIVTPWDVKGSIVDGEEKGIDYERLIVQFGTRKITPEQLERFEKLTGKKPHLLLRRGAFFSHRD 69

  Fly   104 LHTILTLREQGKPFYLYTGRGPSSGSLHVGHLVPFIMTKWLQETFDVPLVIQLTDDEKTLWKD-L 167
            ...||...||.|||||||||||||.|:|:||::||:..||||:.|.||||||||||||.|:|. :
pombe    70 FDMILDRYEQKKPFYLYTGRGPSSDSMHLGHMIPFMFCKWLQDVFQVPLVIQLTDDEKFLFKQGV 134

  Fly   168 KVEDAIKLGRENAKDIVAIGFDVNKTFIFNNLEFVGKCPAMYQNIIRIQKCVTFNQVKGIFGFGD 232
            .:||..:..|||||||:|:|||..|||||.|..:||  .|.|||::||.||:|.||.|..|||.|
pombe   135 SLEDCQRFARENAKDIIAVGFDPKKTFIFMNSTYVG--GAFYQNVVRIAKCITANQSKACFGFTD 197

  Fly   233 SDIIGKIGFPAAQAAPAISSTFPFIF-GNRKVHCLIPCAIDQDPYFRMTRDVAPRLGFPKCALIH 296
            ||.||||.|.:.||||:.||:||.|| |.:.:.||||||||||||||:||||:.||.|.|.||:|
pombe   198 SDSIGKIHFASIQAAPSFSSSFPHIFNGAKDIPCLIPCAIDQDPYFRLTRDVSGRLKFKKPALLH 262

  Fly   297 STFFPALQGAKTKMSASDQNSAVYLTDTPKQIKNKINKYAFSGGRVSVEEHRKLGGVPEVDVSYQ 361
            |.|||||||.::|||||..:||:::||||.:||||||::|||||..::|.||:.||.|:|||:||
pombe   263 SRFFPALQGPQSKMSASKDSSAIFMTDTPNKIKNKINRHAFSGGGATIEIHREKGGNPDVDVAYQ 327

  Fly   362 LLKFFLEDDAKLEEVRVAYSKGEMLTGEIKKLAVETLTPIVEQHQAARKLITDEVLDKYFE 422
            .|.|||:||.||:::...|..|.:.|||:|...::.|...|...||||..:.:..||.:.:
pombe   328 YLSFFLDDDEKLKQLYNTYKAGTLSTGEMKGECIKLLQQFVSDFQAARSKVDEATLDMFMD 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TrpRS	NP_524826.1	PLN02486	45..426	CDD:178104	217/384 (57%)
TrpRS	NP_524826.1	trpS	115..422	CDD:272975	181/308 (59%)
wrs1	NP_592983.1	nt_trans	6..387	CDD:294020	217/382 (57%)
wrs1	NP_592983.1	trpS	81..395	CDD:272975	181/310 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	354	1.000	Domainoid score	I166
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3084
Inparanoid	1	1.050	437	1.000	Inparanoid score	I314
OMA	1	1.010	-	-		QHG62151
OrthoFinder	1	1.000	-	-		FOG0003947
OrthoInspector	1	1.000	-	-		oto101020
orthoMCL	1	0.900	-	-		OOG6_101168
Panther	1	1.100	-	-	LDO	PTHR10055
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1459
SonicParanoid	1	1.000	-	-		X3247
TreeFam	0	0.000	Not matched by this tool.
	12	12.000