DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TrpRS and wars-1

DIOPT Version :9

Sequence 1:	NP_524826.1	Gene:	TrpRS / 45399	FlyBaseID:	FBgn0010803	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_507683.2	Gene:	wars-1 / 180231	WormBaseID:	WBGene00006945	Length:	417	Species:	Caenorhabditis elegans

Alignment Length:	429	Identity:	250/429 - (58%)
Similarity:	315/429 - (73%)	Gaps:	15/429 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADTKETVVEGVEALTLNGKPDAEPVETGTDAQAQEGATAPTEDVVDPWNVASSNDAGVDYDKLI 65
            ||...|.|...:|.|.:||            ..|..|.....||.|.||.|.::...|:||||||
Worm     1 MAAPAEQVAAEIENLKVNG------------GAAGGGVQEDEEDRVTPWEVTTTKATGIDYDKLI 53

  Fly    66 KRFGSSKIDEELIARFEKITGKPAHHFIRRGMFFSHRDLHTILTLREQGKPFYLYTGRGPSSGSL 130
            .:||..|:|||:|||||::||..|...:||||||:||||..||..:|||||||||||||.|||||
Worm    54 VKFGCRKLDEEIIARFERVTGHKASPMLRRGMFFAHRDLTAILDRKEQGKPFYLYTGRGASSGSL 118

  Fly   131 HVGHLVPFIMTKWLQETFDVPLVIQLTDDEKTLWKDLKVEDAIKLGRENAKDIVAIGFDVNKTFI 195
            |:|||||||.||||||.||||||||:|||||.||||:||::|.|:.|||.|||:::|||..||||
Worm   119 HLGHLVPFIFTKWLQEVFDVPLVIQMTDDEKFLWKDMKVDEAKKMARENMKDIISVGFDPTKTFI 183

  Fly   196 FNNLEFVGKCPAMYQNIIRIQKCVTFNQVKGIFGFGDSDIIGKIGFPAAQAAPAISSTFPFIFGN 260
            |||.:::  ||..|:||::|.|.|..||.:.||||...|.:||..|||.:|||..:|:||.|||.
Worm   184 FNNFDYM--CPPFYENIVKIWKVVNTNQARAIFGFTPEDCLGKAAFPAVEAAPCFASSFPQIFGK 246

  Fly   261 RK-VHCLIPCAIDQDPYFRMTRDVAPRLGFPKCALIHSTFFPALQGAKTKMSASDQNSAVYLTDT 324
            |. :.|||||||||||:|||||||||||...|.:||.|||.|||.||:||||||:.|:.::|:||
Worm   247 RNDIPCLIPCAIDQDPFFRMTRDVAPRLKASKPSLIFSTFLPALTGAQTKMSASEPNTCIFLSDT 311

  Fly   325 PKQIKNKINKYAFSGGRVSVEEHRKLGGVPEVDVSYQLLKFFLEDDAKLEEVRVAYSKGEMLTGE 389
            .|||||||||||||||:.:|:|||:.||..:||:|||.|:|||:||.||.|:|..|:|||||:||
Worm   312 AKQIKNKINKYAFSGGQQTVQEHREKGGNCDVDISYQFLRFFLDDDEKLAEIRENYTKGEMLSGE 376

  Fly   390 IKKLAVETLTPIVEQHQAARKLITDEVLDKYFELRPLKF 428
            :|.||.:.:..||.:.|..|||:|||.::::.::|||.:
Worm   377 LKALATQKVQEIVLEMQERRKLVTDETVEEFVKVRPLAY 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TrpRS	NP_524826.1	PLN02486	45..426	CDD:178104	236/381 (62%)
TrpRS	NP_524826.1	trpS	115..422	CDD:272975	195/307 (64%)
wars-1	NP_507683.2	PLN02486	34..414	CDD:178104	237/381 (62%)
wars-1	NP_507683.2	trpS	103..416	CDD:272975	198/315 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159997
Domainoid	1	1.000	94	1.000	Domainoid score	I4757
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3084
Inparanoid	1	1.050	503	1.000	Inparanoid score	I738
Isobase	1	0.950	-	0	Normalized mean entropy	S449
OMA	1	1.010	-	-		QHG62151
OrthoDB	1	1.010	-	-		D300066at33208
OrthoFinder	1	1.000	-	-		FOG0003947
OrthoInspector	1	1.000	-	-		oto18831
orthoMCL	1	0.900	-	-		OOG6_101168
Panther	1	1.100	-	-	LDO	PTHR10055
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1459
SonicParanoid	1	1.000	-	-		X3247
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890