DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh-III and ALD6

DIOPT Version :9

Sequence 1:	NP_724562.2	Gene:	Aldh-III / 45398	FlyBaseID:	FBgn0010548	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_015264.1	Gene:	ALD6 / 856044	SGDID:	S000005982	Length:	500	Species:	Saccharomyces cerevisiae

Alignment Length:	514	Identity:	121/514 - (23%)
Similarity:	200/514 - (38%)	Gaps:	99/514 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 ESPIGIFTSQPESQQQQPEQLQSESESDRMANFDDTLQRARLAFSSGKTRNVSFRRKQLENLLRC 102
            |.|.|:|.:....:.|..:....|         |.:.:......||..|.:|       |..:.|
Yeast    23 EQPTGLFINNKFMKAQDGKTYPVE---------DPSTENTVCEVSSATTEDV-------EYAIEC 71

  Fly   103 YEE--HENE-----------IISALEADLRRPKQESLIVETEFMKNDIRHILFQLDEWVQSEKPP 154
            .:.  |:.|           ::|.|..:|.  .|..|:...|.:.|.....|.:.|..:.
Yeast    72 ADRAFHDTEWATQDPRERGRLLSKLADELE--SQIDLVSSIEALDNGKTLALARGDVTIA----- 129

  Fly   155 KSFVNMMDDVQIYND--------------------PFGVVLVIGAWNYPLQLLLVPVASAIAAGN 199
               :|.:.|...|.|                    |.||...|..||:|:.:|...:|.|:|.||
Yeast   130 ---INCLRDAAAYADKVNGRTINTGDGYMNFTTLEPIGVCGQIIPWNFPIMMLAWKIAPALAMGN 191

  Fly   200 CVVIKPSEIAANCAKFIADV-----IPKYLDNDCYPVVCGGPSET--AELLNQ-RFDYIFYTGST 256
            ..::||:.:....|.:.|.:     ||..:.|     :..||..|  |.|.|. |...:.:||||
Yeast   192 VCILKPAAVTPLNALYFASLCKKVGIPAGVVN-----IVPGPGRTVGAALTNDPRIRKLAFTGST 251

  Fly   257 RVGKIIHA-AANKYLTPTTLELGGKSPCYIDKSVDMRTAVKRILWGKLINCGQTCIAPDYILCSK 320
            .|||.:.. ::...|...||||||||...:....:::..:..::.|...|.||.|.:...|...:
Yeast   252 EVGKSVAVDSSESNLKKITLELGGKSAHLVFDDANIKKTLPNLVNGIFKNAGQICSSGSRIYVQE 316

  Fly   321 EVQEKFIVEAKDVLKE--WYGENIQSSPDLSRVINANNFQRL-----LGLMKSGRVAVGGNYDAS 378
            .:.::.:...|..|:.  ..|.....:.....:.|...|..:     :|..:..::..||.....
Yeast   317 GIYDELLAAFKAYLETEIKVGNPFDKANFQGAITNRQQFDTIMNYIDIGKKEGAKILTGGEKVGD 381

  Fly   379 E-RFIEPTILVDVKETDPIMEEEIFGPILPIFNVESAYDAIKFINAREKPLVIYV----FSNSNK 438
            : .||.||:..||.|...|::||||||::.:...::..:.::..|:.|..|...:    .|...|
Yeast   382 KGYFIRPTVFYDVNEDMRIVKEEIFGPVVTVAKFKTLEEGVEMANSSEFGLGSGIETESLSTGLK 446

  Fly   439 LVKEFRRST----TSGGFSSNETIMHCGVDVLPFGGVGMSGMGRYHGKYGFETFTHKKS 493
            :.|..:..|    |...|.|.          :|||||..||.||..|:..:..:|..|:
Yeast   447 VAKMLKAGTVWINTYNDFDSR----------VPFGGVKQSGYGREMGEEVYHAYTEVKA 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh-III	NP_724562.2	ALDH_F3AB	72..515	CDD:143450	114/480 (24%)
ALD6	NP_015264.1	ALDH_F1-2_Ald2-like	23..498	CDD:143410	121/514 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344471
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740