DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh-III and ALD3

DIOPT Version :9

Sequence 1:	NP_724562.2	Gene:	Aldh-III / 45398	FlyBaseID:	FBgn0010548	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_013892.1	Gene:	ALD3 / 855205	SGDID:	S000004779	Length:	506	Species:	Saccharomyces cerevisiae

Alignment Length:	514	Identity:	150/514 - (29%)
Similarity:	232/514 - (45%)	Gaps:	79/514 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 ESPIGIFTSQ---PESQQQQPE-----------QLQSESESDRMANFDDTLQRARLAFSSGKTRN 88
            :.|:|:|.:.   |.|..:..|           ..|:.:|.|    .|..::.||.||.:..::.
Yeast    18 KQPLGLFINNEFCPSSDGKTIETVNPATGEPITSFQAANEKD----VDKAVKAARAAFDNVWSKT 78

  Fly    89 VSFRRK-QLENLLRCYEEHENEIISALEA-DLRRP-----KQE-SLIVETEFMKNDIRHILFQLD 145
            .|.:|. .|.|||:..|| |.:.::|||. |..:|     ||: :.|:|.      .|:....:|
Yeast    79 SSEQRGIYLSNLLKLIEE-EQDTLAALETLDAGKPFHSNAKQDLAQIIEL------TRYYAGAVD 136

  Fly   146 EWVQSEKPPKSFVNMMDDVQIYNDPFGVVLVIGAWNYPLQLLLVPVASAIAAGNCVVIKPSEIAA 210
            ::...|..|.:|......:::   |||||..|..|||||.:....:..|:||||.|:|||:|..:
Yeast   137 KFNMGETIPLTFNKFAYTLKV---PFGVVAQIVPWNYPLAMACRKMQGALAAGNTVIIKPAENTS 198

  Fly   211 NCAKFIADVIPKYLDNDCYP-----VVCGGPSETAELLNQRFDY--IFYTGSTRV-GKIIHAAAN 267
            ....:.|.:|.|    ..:|     |:.|..|...:.|....|.  |.:||||:| |.::.|:..
Yeast   199 LSLLYFATLIKK----AGFPPGVVNVIPGYGSVVGKALGTHMDIDKISFTGSTKVGGSVLEASGQ 259

  Fly   268 KYLTPTTLELGGKSPCYIDKSVDMRTAVKRILWGKLINCGQTCIAPDYILCSKEVQEKFIVEAKD 332
            ..|...|||.|||||..:.:..|:..|::.:..|...|.||.|.|...:.....:.:||:.:.|:
Yeast   260 SNLKDITLECGGKSPALVFEDADLDKAIEWVANGIFFNSGQICTANSRVYVQSSIYDKFVEKFKE 324

  Fly   333 VL-KEW--------YGENIQSSPDLSRVINANNFQRL------------LGLMKSGRVAVGGNYD 376
            .. |||        :.|.....|    ||::..:.|:            |.:.::....:||
Yeast   325 TAKKEWDVAGKFDPFDEKCIVGP----VISSTQYDRIKSYIERGKKEEKLDMFQTSEFPIGG--- 382

  Fly   377 ASERFIEPTILVDVKETDPIMEEEIFGPILPIFNVESAYDAIKFINAREKPLVIYVFSNSNKLVK 441
            |...||.|||..||.||..::.:|||||::.:....:..||:|..|.....|...||:...|...
Yeast   383 AKGYFIPPTIFTDVPETSKLLRDEIFGPVVVVSKFTNYDDALKLANDTCYGLASAVFTKDVKKAH 447

  Fly   442 EFRRSTTSGGFSSNETIMHCGVDVLPFGGVGMSGMGRYHGKYGFETFTHKKSCLGKDLS 500
            .|.|...:|....|:|...  ...:||||..|||:||..|..|.:.:...|| :..|||
Yeast   448 MFARDIKAGTVWINQTNQE--EAKVPFGGFKMSGIGRESGDTGVDNYLQIKS-VHVDLS 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh-III	NP_724562.2	ALDH_F3AB	72..515	CDD:143450	140/466 (30%)
ALD3	NP_013892.1	ALDH-SF	14..502	CDD:416387	147/511 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810