DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh-III and Aldh3b3

DIOPT Version :9

Sequence 1:	NP_724562.2	Gene:	Aldh-III / 45398	FlyBaseID:	FBgn0010548	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_082821.2	Gene:	Aldh3b3 / 73458	MGIID:	1920708	Length:	479	Species:	Mus musculus

Alignment Length:	458	Identity:	222/458 - (48%)
Similarity:	324/458 - (70%)	Gaps:	4/458 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 FDDTLQRARLAFSSGKTRNVSFRRKQLENLLRCYEEHENEIISALEADLRRPKQESLIVETEFMK 134
            |::.|||.:.||::|||:...||.:||::|.|..:::..::..||:.||.:...||.:.|....:
Mouse    17 FEEKLQRLKEAFNTGKTKTAKFRAEQLQSLGRFLQDNSKQLHDALDGDLGKSGFESDMSEIILCE 81

  Fly   135 NDIRHILFQLDEWVQSEKPPKSFVNMMDDVQIYNDPFGVVLVIGAWNYPLQLLLVPVASAIAAGN 199
            |::...|..|..|::.|....:.:..:....|..:|||:||:|..||||:.|:::|:..||||||
Mouse    82 NEVDLALKNLQTWMKDEPVSTNLLTKLSTAFIRKEPFGLVLIIAPWNYPVNLMIIPLVGAIAAGN 146

  Fly   200 CVVIKPSEIAANCAKFIADVIPKYLDNDCYPVVCGGPSETAELLNQRFDYIFYTGSTRVGKIIHA 264
            |||:|||||:.|..|.:|:::|:|||..|:.|:.|||.||.:||..:|||||:|||.|||||:..
Mouse   147 CVVLKPSEISKNTEKVLAELLPQYLDQSCFAVMLGGPEETGQLLEHKFDYIFFTGSPRVGKIVMT 211

  Fly   265 AANKYLTPTTLELGGKSPCYIDKSVDMRTAVKRILWGKLINCGQTCIAPDYILCSKEVQEKFIVE 329
            ||.|:|||.|||||||:|||:|.:.|.:|...|:.|.:..|.||||:||||||||:|:||:.:..
Mouse   212 AAAKHLTPITLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYILCSQEMQEQLVPA 276

  Fly   330 AKDVLKEWYGENIQSSPDLSRVINANNFQRLLGLMKSGRVAVGGNYDASERFIEPTILVDVKETD 394
            .::.:..:||:|.|:||:|.|:||..:|:||.||:..||||:||..|..||:|.||:||||:||:
Mouse   277 LQNAITRFYGDNPQTSPNLGRIINQKHFKRLQGLLGCGRVAIGGQSDEGERYIAPTVLVDVQETE 341

  Fly   395 PIMEEEIFGPILPIFNVESAYDAIKFINAREKPLVIYVFSNSNKLVKEFRRSTTSGGFSSNETIM 459
            |:|:|||||||||:..|.|..:||:|:|.|||||.:|.:||:.:::|:....|:||||..|:..|
Mouse   342 PVMQEEIFGPILPLVTVRSLDEAIEFMNQREKPLALYAYSNNAEVIKQVLARTSSGGFCGNDGFM 406

  Fly   460 HCGVDVLPFGGVGMSGMGRYHGKYGFETFTHKKSCLGKDLS-PLGEKLSSARYPPYSDRKGSLLS 523
            :..:..|||||||.|||||||||:.|:||:::::||   || |..|||:..||||||.|:..||.
Mouse   407 YMTLSSLPFGGVGSSGMGRYHGKFSFDTFSNQRACL---LSCPGMEKLNGLRYPPYSPRRQQLLR 468

  Fly   524 FLL 526
            :.:
Mouse   469 WAI 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh-III	NP_724562.2	ALDH_F3AB	72..515	CDD:143450	216/443 (49%)
Aldh3b3	NP_082821.2	ALDH_F3AB	18..460	CDD:143450	216/444 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844269
Domainoid	1	1.000	450	1.000	Domainoid score	I512
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	474	1.000	Inparanoid score	I1482
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62894
OrthoDB	1	1.010	-	-		D225045at33208
OrthoFinder	1	1.000	-	-		FOG0000656
OrthoInspector	1	1.000	-	-		otm44367
orthoMCL	1	0.900	-	-		OOG6_100557
Panther	1	1.100	-	-	O	PTHR43570
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2145
SonicParanoid	1	1.000	-	-		X395
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800