DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh-III and Aldh3b1

DIOPT Version :9

Sequence 1:	NP_724562.2	Gene:	Aldh-III / 45398	FlyBaseID:	FBgn0010548	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_080592.2	Gene:	Aldh3b1 / 67689	MGIID:	1914939	Length:	468	Species:	Mus musculus

Alignment Length:	463	Identity:	223/463 - (48%)
Similarity:	317/463 - (68%)	Gaps:	2/463 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 MANFDDTLQRARLAFSSGKTRNVSFRRKQLENLLRCYEEHENEIISALEADLRRPKQESLIVETE 131
            |.:|:|.||:.|.||..|:||:..||..||:.|.....:::.::..||..||.:...|:.:.|..
Mouse     1 MDSFEDKLQQLREAFKEGRTRSAEFRAAQLQGLSHFLRDNKQQLQEALAQDLHKSAFEAEVSEIA 65

  Fly   132 FMKNDIRHILFQLDEWVQSEKPPKSFVNMMDDVQIYNDPFGVVLVIGAWNYPLQLLLVPVASAIA 196
            ..:.::...|..|..|::.||..|:....:|...|..:|||:||:|..||||:.|.|||:..|||
Mouse    66 ISQAEVDLALRNLRSWMKDEKVSKNLATQLDSAFIRKEPFGLVLIIVPWNYPINLTLVPLVGAIA 130

  Fly   197 AGNCVVIKPSEIAANCAKFIADVIPKYLDNDCYPVVCGGPSETAELLNQRFDYIFYTGSTRVGKI 261
            ||||||:|||||:....|.:|:|:|:|||..|:.||.||..||.:||..:|||||:||:..||||
Mouse   131 AGNCVVLKPSEISKATEKILAEVLPRYLDQSCFTVVLGGRQETGQLLEHKFDYIFFTGNAYVGKI 195

  Fly   262 IHAAANKYLTPTTLELGGKSPCYIDKSVDMRTAVKRILWGKLINCGQTCIAPDYILCSKEVQEKF 326
            :.|||.|:|||.|||||||:|||:|.:.|.:....|:.|.:..|.||||:||||||||:|:||:.
Mouse   196 VMAAAAKHLTPITLELGGKNPCYVDDNCDPQIVANRVAWFRYFNAGQTCVAPDYILCSQEMQERL 260

  Fly   327 IVEAKDVLKEWYGENIQSSPDLSRVINANNFQRLLGLMKSGRVAVGGNYDASERFIEPTILVDVK 391
            :...::.:..:||:|.|:||:|.|:||..:|:||.||:..||||:||..|..||:|.||:||||:
Mouse   261 VPALQNAITRFYGDNPQTSPNLGRIINQKHFKRLQGLLGCGRVAIGGQSDEGERYIAPTVLVDVQ 325

  Fly   392 ETDPIMEEEIFGPILPIFNVESAYDAIKFINAREKPLVIYVFSNSNKLVKEFRRSTTSGGFSSNE 456
            ||:|:|:|||||||||:..|.|..:||:|:|.|||||.:|.||..::::|:....|:||||..|:
Mouse   326 ETEPVMQEEIFGPILPLVTVRSLDEAIEFMNRREKPLALYAFSKRSQVIKQVLARTSSGGFCGND 390

  Fly   457 TIMHCGVDVLPFGGVGMSGMGRYHGKYGFETFTHKKSCLGKDLSPLGEKLSSARYPPYSDRKGSL 521
            ..||..:..|||||||.|||||||||:.|:||:::::||.:  ||..||::..||||||.|...:
Mouse   391 GFMHMTLSSLPFGGVGTSGMGRYHGKFSFDTFSNQRACLLR--SPGMEKINDLRYPPYSSRNLRV 453

  Fly   522 LSFLLRKR 529
            |...:.:|
Mouse   454 LLVAMEER 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh-III	NP_724562.2	ALDH_F3AB	72..515	CDD:143450	216/442 (49%)
Aldh3b1	NP_080592.2	ALDH_F3AB	5..447	CDD:143450	216/443 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	450	1.000	Domainoid score	I512
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H73890
Inparanoid	1	1.050	474	1.000	Inparanoid score	I1482
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62894
OrthoDB	1	1.010	-	-		D225045at33208
OrthoFinder	1	1.000	-	-		FOG0000656
OrthoInspector	1	1.000	-	-		otm44367
orthoMCL	1	0.900	-	-		OOG6_100557
Panther	1	1.100	-	-	O	PTHR43570
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2145
SonicParanoid	1	1.000	-	-		X395
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.870