DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh-III and Aldh3a2

DIOPT Version :9

Sequence 1:	NP_724562.2	Gene:	Aldh-III / 45398	FlyBaseID:	FBgn0010548	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_006246591.1	Gene:	Aldh3a2 / 65183	RGDID:	61866	Length:	584	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	241/525 - (45%)
Similarity:	337/525 - (64%)	Gaps:	25/525 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 PIGIFTSQPESQQQQPEQLQSESESDRMANFDDTLQRARLAFSSGKTRNVSFRRKQLENLLRCYE 104
            |...|:|.|..::|                    :||.|..|.||::|.:.||.:|||.|.|..:
  Rat    68 PRSAFSSGPAMERQ--------------------VQRLRQTFRSGRSRPLRFRLQQLEALRRMVQ 112

  Fly   105 EHENEIISALEADLRRPKQESLIVETEFMKNDIRHILFQLDEWVQSEKPPKSFVNMMDDVQIYND 169
            |.|.:|::|:.|||.:.:..:...|...:..:|..:|..|.|...:....|:.:.|||:..:..:
  Rat   113 EREKDILAAIAADLSKSELNAYSHEVITILGEIDFMLGNLPELASARPAKKNLLTMMDEAYVQPE 177

  Fly   170 PFGVVLVIGAWNYPLQLLLVPVASAIAAGNCVVIKPSEIAANCAKFIADVIPKYLDNDCYPVVCG 234
            |.||||:|||||||..|.|.|:..||||||..::||||::.|.||.:|:::|:|||.|.|.:|.|
  Rat   178 PLGVVLIIGAWNYPFVLTLQPLVGAIAAGNAAIVKPSELSENTAKILAELLPQYLDQDLYMIVNG 242

  Fly   235 GPSETAELLNQRFDYIFYTGSTRVGKIIHAAANKYLTPTTLELGGKSPCYIDKSVDMRTAVKRIL 299
            |..||.|||.||||:|.|||:|.||||:..||.|:|||.|||||||||||||:..|:..|.:||.
  Rat   243 GVEETTELLRQRFDHILYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDRDCDLDVACRRIT 307

  Fly   300 WGKLINCGQTCIAPDYILCSKEVQEKFIVEAKDVLKEWYGENIQSSPDLSRVINANNFQRLLGLM 364
            |||.:||||||||||||||...:|::.:.:.||.:|::||||:::|||..|:||..:|:|:..|:
  Rat   308 WGKYMNCGQTCIAPDYILCEASLQDQIVQKIKDTVKDFYGENVKASPDYERIINLRHFKRIKSLL 372

  Fly   365 KSGRVAVGGNYDASERFIEPTILVDVKETDPIMEEEIFGPILPIFNVESAYDAIKFINAREKPLV 429
            :..::|.||..|.:.|:|.||||.||.....:|:||||||||||.:|::..:||.|||.|||||.
  Rat   373 EGQKIAFGGETDEATRYIAPTILTDVDPNSKVMQEEIFGPILPIVSVKNVEEAINFINDREKPLA 437

  Fly   430 IYVFSNSNKLVKEFRRSTTSGGFSSNETIMHCGVDVLPFGGVGMSGMGRYHGKYGFETFTHKKSC 494
            :|:||::|||:|.....|:|||.:.|:.|||..|:.|||||||.||||.|||||.|:||:|::.|
  Rat   438 LYIFSHNNKLIKRVIDETSSGGVTGNDVIMHFTVNSLPFGGVGASGMGAYHGKYSFDTFSHQRPC 502

  Fly   495 LGKDLSPLGEKLSSARYPPYSDRKGSLLSFLLRKRRPLPNLHLSHVLAIGLGVGLTVLTNYYL-- 557
            |.|.|.  ||.::..||||.|:.|.|...|.|.|:.....|.|..::.: :.|...::..|..
  Rat   503 LLKGLK--GESVNKLRYPPNSESKVSWSKFFLLKQFNKGRLQLLLLVCL-VAVAAVIVKKYQALW 564

  Fly   558 QGKLL 562
            :||.|
  Rat   565 RGKAL 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh-III	NP_724562.2	ALDH_F3AB	72..515	CDD:143450	223/442 (50%)
Aldh3a2	XP_006246591.1	ALDH_F3AB	82..521	CDD:143450	223/440 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	451	1.000	Domainoid score	I490
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62894
OrthoDB	1	1.010	-	-		D225045at33208
OrthoFinder	1	1.000	-	-		FOG0000656
OrthoInspector	1	1.000	-	-		otm46464
orthoMCL	1	0.900	-	-		OOG6_100557
Panther	1	1.100	-	-	O	PTHR43570
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X395
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.830