DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh-III and Aldh9a1

DIOPT Version :9

Sequence 1:	NP_724562.2	Gene:	Aldh-III / 45398	FlyBaseID:	FBgn0010548	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_064377.2	Gene:	Aldh9a1 / 56752	MGIID:	1861622	Length:	518	Species:	Mus musculus

Alignment Length:	508	Identity:	131/508 - (25%)
Similarity:	208/508 - (40%)	Gaps:	77/508 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PINAAGDRPITTVINIEPEPETESPIGIFTSQPESQQQQPEQLQSESESDRMANFDDTLQRARLA 80
            |::|:|.....       ||.|...|..|....|.:                .|.  .::.|:.|
Mouse    46 PVDASGTEKAF-------EPATGRVIATFACSGEKE----------------VNL--AVENAKAA 85

  Fly    81 FSSGKTRNVSFRRKQLENLLRCYEEHENEIISALEADLRRPKQESLIVETEFMKNDIRHILFQLD 145
            |.....::...|.:.|....|..:|.::||.:               |||......|......:|
Mouse    86 FKLWSKKSGLERCQVLLEAARIIKERKDEIAT---------------VETINNGKSIFEARLDVD 135

  Fly   146 E-WVQSEKPPKSFVNMM-DDVQI--------YNDPFGVVLVIGAWNYPLQLLLVPVASAIAAGNC 200
            . |...|.......:|. :.:|:        ..:|.||.:.|||||||.|:.....|.|:|.||.
Mouse   136 TCWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIACWKSAPALACGNA 200

  Fly   201 VVIKPSEIAANCAKFIADVIPKY-LDNDCYPVVCGGPSETAELL--NQRFDYIFYTGSTRVGKII 262
            ::.|||......|..:|::..|. .....:.||.|| :.|.:.|  ::....|.:|||...|..|
Mouse   201 MIFKPSPFTPVSALLLAEIYTKAGAPPGLFNVVQGG-AATGQFLCHHREVAKISFTGSVPTGVKI 264

  Fly   263 HAAANKYLTPTTLELGGKSPCYIDKSVDMRTAVKRILWGKLINCGQTCIAPDYILCSKEVQEKFI 327
            ...:.|.:.|.|||||||||..|....:|..|||..|....:..||.|.....:...||:.:|||
Mouse   265 MEMSAKGVKPITLELGGKSPLIIFSDCNMENAVKGALMANFLTQGQVCCNGTRVFVQKEIADKFI 329

  Fly   328 VE-AKDVLKEWYGENIQSSPDLSRVINANNFQRLLGLMKSGR-----VAVGGNYDASE------- 379
            .| .|...|...|:.:.....:..:|||.:.:|:||.:|..:     |..||.....|
Mouse   330 NEVVKQTQKIKLGDPLLEDTRMGPLINAPHLERVLGFVKLAKEQGATVLCGGEVYVPEDPKLKHG 394

  Fly   380 RFIEPTILVDVKETDPIMEEEIFGPILPIFNVESAYDAIKFINAREKPLVIYVFS----NSNKLV 440
            .::.|.||.:.::....::||||||::.|....:..:.::..|.....|...||:    .::::.
Mouse   395 YYMTPCILTNCRDDMTCVKEEIFGPVMSILTFGTEAEVLERANDTTFGLAAGVFTRDIQRAHRVA 459

  Fly   441 KEFRRSTTSGGFSSNETIMHCGVDVLPFGGVGMSGMGRYHGKYGFETFTHKKS 493
            .|.:..|.   :.:|..:...   .|||||...||.||.:|:...|.::..|:
Mouse   460 AELQAGTC---YINNYNVSPV---ELPFGGYKKSGFGRENGRVTIEYYSQLKT 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh-III	NP_724562.2	ALDH_F3AB	72..515	CDD:143450	121/452 (27%)
Aldh9a1	NP_064377.2	ALDH_F9_TMBADH	55..512	CDD:143409	128/499 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810