DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh-III and aldh1l1

DIOPT Version :9

Sequence 1:	NP_724562.2	Gene:	Aldh-III / 45398	FlyBaseID:	FBgn0010548	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001011027.1	Gene:	aldh1l1 / 496436	XenbaseID:	XB-GENE-1016237	Length:	902	Species:	Xenopus tropicalis

Alignment Length:	470	Identity:	128/470 - (27%)
Similarity:	205/470 - (43%)	Gaps:	71/470 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 RMANFDDTLQRARLAFSSGK--TRNVSFRRKQLENLLRCYEEHENEIISALEADLRRPKQESLIV 128
            ::::.|..:..|:.||.:|:  ..|...|.:.|..|....|||:.|:.:....|       |..|
Frog   457 QVSDIDRAVAAAKEAFENGEWGKMNPRDRGRILYRLADIMEEHQEELATIESID-------SGAV 514

  Fly   129 ETEFMKNDIRHILFQLDEWVQSEKPPKSFVNMMDDVQ-----------------IYNDPFGVVLV 176
            .|..:|.   |:...:..:       :.|....|.:|                 ...:|.||..:
Frog   515 YTLALKT---HVGMSIQTF-------RYFAGWCDKIQGSTIPINQARPNRNLTFTRREPIGVCGI 569

  Fly   177 IGAWNYPLQLLLVPVASAIAAGNCVVIKPSEIAANCAKFIADV-----IPKYLDNDCYPVVCGGP 236
            :..|||||.:|....|:.:||||.||:||:::....|...|::     |||.:.|    ::.|..
Frog   570 VIPWNYPLMMLAWKTAACLAAGNTVVLKPAQVTPLTALKFAELSVKAGIPKGVIN----ILPGAG 630

  Fly   237 SETAELLNQRFDY--IFYTGSTRVGK-IIHAAANKYLTPTTLELGGKSPCYIDKSVDMRTAVKRI 298
            |...:.|:...|.  |.:||||.:|| |:.:.|...:...:||||||||..|.:..|:..||:..
Frog   631 SLIGQRLSDHPDVRKIGFTGSTPIGKHIMKSCAVGNVKKVSLELGGKSPLIIFQDCDLDKAVRMG 695

  Fly   299 LWGKLINCGQTCIAPDYILCSKEVQEKFIVE-AKDVLKEWYGENIQSSPDLSRVINANNFQRLL- 361
            :.....|.|:.|||...:...:.:.::|:.. ..:|.|...|:.:..|.|.....:..:..:|:
Frog   696 MSSVFFNKGENCIAAGRLFLEESIHDEFVKRVVGEVKKMKIGDPLDRSTDHGPQNHKAHLDKLIE 760

  Fly   362 ----GLMKSGRVAVGGNYDASER---FIEPTILVDVKETDPIMEEEIFGPILPI--FNVESAYDA 417
                |:.:..::..||.  ..||   |.||||..||.:...|.:||.||||:.|  |......:.
Frog   761 YCQTGVKEGAKLVYGGK--QVERPGFFFEPTIFTDVTDEMFIAKEESFGPIMIISKFKDGDVDEV 823

  Fly   418 IKFINAREKPLVIYVFSN--SNKL-VKEFRRSTTSGGFSSNETIMHCGVDV-LPFGGVGMSGMGR 478
            :|..|..|..|...||:.  |..| |.|..::.|....:.|:|      || .||||...||.|:
Frog   824 LKRANNTEFGLASGVFTKDISKALYVSEKLQAGTVFVNTYNKT------DVAAPFGGFKQSGFGK 882

  Fly   479 YHGKYGFETFTHKKS 493
            ..|:.....:...|:
Frog   883 DLGEEALNEYLKTKA 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh-III	NP_724562.2	ALDH_F3AB	72..515	CDD:143450	127/464 (27%)
aldh1l1	NP_001011027.1	FMT_core_FDH_N	1..203	CDD:187716
		GART	1..203
		FDH_Hydrolase_C	206..305	CDD:187731
		PP-binding	325..391	CDD:376348
		ALDH_F1L_FTFDH	417..902	CDD:143458	128/470 (27%)
		Aldehyde dehydrogenase	417..902		128/470 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910