DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh-III and aldh16a1

DIOPT Version :9

Sequence 1:	NP_724562.2	Gene:	Aldh-III / 45398	FlyBaseID:	FBgn0010548	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001073423.2	Gene:	aldh16a1 / 492710	ZFINID:	ZDB-GENE-070112-2062	Length:	795	Species:	Danio rerio

Alignment Length:	538	Identity:	117/538 - (21%)
Similarity:	192/538 - (35%)	Gaps:	127/538 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 IGIFT----SQPESQQQQPEQLQSESE---SDRMANFDDTLQRARLAFSSGKTRNVSFRRKQLEN 98
            :|.|.    |.|..:|.| :.:.|::.   |...|..:|.......|.:..||          .:
Zfish    39 LGFFIDGKFSHPADRQTQ-DVIDSKAAVVCSTVCAQAEDVASAVSSAAAGFKT----------WS 92

  Fly    99 LLRCYEEHENEIISALEADLRRPKQESLIVETEFMKNDIRHILFQLDEWVQSEKPPKSFVNMMDD 163
            .|.||:  ..:::..|...|:|..|                .:.::.|..||...|...:.:
Zfish    93 QLSCYQ--RAKVLLKLPGVLQRHSQ----------------CVSEVCELSQSTTSPAVLIRL--- 136

  Fly   164 VQIYN-------------DPFGVVLVIGAWNYPLQLLLVPVASAIAAGNCVVIKPSEIAANCAKF 215
            .|.|.             .|.|||.|:.:.:..:..||:.|..|:|.||.|::.|.:..|.....
Zfish   137 AQYYASWAQLRDTRMPEWSPQGVVTVVVSDDCSVYFLLLKVLPALAMGNAVIVVPGKTTALPGLL 201

  Fly   216 IADV-----IPKYLDNDCYPVVCGGPSETAELL--NQRFDYIFYTGSTRVGKIIHAAANKYLTPT 273
            :|.:     :|..:.|    |:.|..:..|..:  |.:.:|:.::|..:.|:.:..||..:..|.
Zfish   202 LAQLFMEAGMPAGVLN----VLTGSEASLAAKMAQNPQVNYLTFSGCRQTGEAVAKAAAGWGVPM 262

  Fly   274 TLELGGKSPC--YIDKSVDMRTAVKRIL-----------WGKLINCGQTCIAPDYILCSKE-VQE 324
            |..|...|.|  .|.:|.|:.:||..::           |               :||.:| |.:
Zfish   263 TFSLSSSSVCPFIIFESADLDSAVDGVIELAFKKKRDFQW---------------VLCVQESVLD 312

  Fly   325 KFIVEAKDVLKEWYGENIQSSPDLSRV---INANNFQRLLGLMKSGRVAVGGNYDASERFIEPTI 386
            ..:...|..:.|..|..:.|.||.|.:   |.....|....:......:.||.|       .||:
Zfish   313 SVVARLKTRMAEMKGVPLASDPDRSIIDAAIQEAQQQGATLIQSCPPASTGGLY-------PPTV 370

  Fly   387 LVDVKETDPIMEEEIF---GPILPIFNVESAYDAIKFINAREKPLVIYVFSNSNKLVKEFRRSTT 448
            |..:.   |..|..|.   ||:||:....|:.:.:...|.........:::....|..|..:|..
Zfish   371 LCGLA---PSCESVISPPPGPVLPLITFRSSAEGVTLGNHSPHGQAASIWTEDLTLALESAKSLC 432

  Fly   449 SGGFSSNETIMHCGVD-VLPFGGVGMSGMGRYHGKYGFETFTHKKSCLGKDLSPLGEKLSSARYP 512
            .|....|   .|..:| .||..|...||.....|:.|...|      |...|||     |..|..
Zfish   433 VGSVWVN---CHSVMDPALPLCGRRDSGNCTDGGREGLYQF------LRPSLSP-----SLPRSS 483

  Fly   513 P----YSDRKGSLLSFLL 526
            |    |:|...:...|::
Zfish   484 PSSVNYADFGSAPSKFMI 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh-III	NP_724562.2	ALDH_F3AB	72..515	CDD:143450	105/487 (22%)
aldh16a1	NP_001073423.2	ALDH-SF	18..470	CDD:299846	106/494 (21%)
aldh16a1	NP_001073423.2	AdhE	514..>755	CDD:223944
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900