DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh-III and aldh3a2b

DIOPT Version :9

Sequence 1:	NP_724562.2	Gene:	Aldh-III / 45398	FlyBaseID:	FBgn0010548	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001315147.1	Gene:	aldh3a2b / 447920	ZFINID:	ZDB-GENE-040912-103	Length:	490	Species:	Danio rerio

Alignment Length:	490	Identity:	230/490 - (46%)
Similarity:	319/490 - (65%)	Gaps:	2/490 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 MANFDDTLQRARLAFSSGKTRNVSFRRKQLENLLRCYEEHENEIISALEADLRRPKQESLIVETE 131
            |:.....::|||.||.:|:::::.:|..||:||.|..:|.:.||..||:.||:|.:..:.:.||.
Zfish     1 MSREQKAVERARKAFFTGRSKSLEYRISQLKNLQRFMQERQKEIAEALKKDLKRSEFGTSLYETL 65

  Fly   132 FMKNDIRHILFQLDEWVQSEKPPKSFVNMMDDVQIYNDPFGVVLVIGAWNYPLQLLLVPVASAIA 196
            .::::|...|.:|.||.......||.:.:.|.|.|..:|.||||:|||||||..:.:.|:..|||
Zfish    66 GVESEINLALKKLKEWAAPRPVNKSLMTISDQVYIQPEPLGVVLIIGAWNYPWAVTVGPLVGAIA 130

  Fly   197 AGNCVVIKPSEIAANCAKFIADVIPKYLDNDCYPVVCGGPSETAELLNQRFDYIFYTGSTRVGKI 261
            |||..||||||::|:.:|.:.:.:|.|||.:.||||.||..||.|||.||||:|||||:..||||
Zfish   131 AGNAAVIKPSEVSAHTSKVMEEFLPLYLDKELYPVVTGGVKETQELLKQRFDHIFYTGNGMVGKI 195

  Fly   262 IHAAANKYLTPTTLELGGKSPCYIDKSVDMRTAVKRILWGKLINCGQTCIAPDYILCSKEVQEKF 326
            |..||.|:||||||||||||||||||..|:..|.:||.|||..||||||||||||||...:|::.
Zfish   196 IMEAAAKHLTPTTLELGGKSPCYIDKDCDLTIACRRIAWGKYSNCGQTCIAPDYILCDPSIQDRV 260

  Fly   327 IVEAKDVLKEWYGENIQSSPDLSRVINANNFQRLLGLMKSGRVAVGGNYDASERFIEPTILVDVK 391
            |.|.|..:||:|.||.|..||..|:||..:|:||:.||:...:||.|.::.:|.:|.||:|.|||
Zfish   261 IEEIKKNIKEFYTENPQKCPDYGRIINQRHFKRLMSLMEGSSIAVSGEHNEAECYIAPTVLRDVK 325

  Fly   392 ETDPIMEEEIFGPILPIFNVESAYDAIKFINAREKPLVIYVFSNSNKLVKEFRRSTTSGGFSSNE 456
            ....:|:||||||:|||..|.|..:||||||.|:|||.:|:||:..||:......|:|||..:|:
Zfish   326 PDAKVMQEEIFGPLLPIVTVNSVDEAIKFINQRDKPLALYIFSSDKKLIDRMIAETSSGGLMAND 390

  Fly   457 TIMHCGVDVLPFGGVGMSGMGRYHGKYGFETFTHKKSCLGKDLSPLGEKLSSARYPPYSDRKGSL 521
            .:||..|..|||||||.|||||||||:||:..:|.:..|.|.|..  |.::..||||::..|...
Zfish   391 CLMHFSVSSLPFGGVGDSGMGRYHGKHGFDNLSHMRGVLLKQLKM--EAVNKMRYPPHTADKLGW 453

  Fly   522 LSFLLRKRRPLPNLHLSHVLAIGLGVGLTVLTNYY 556
            ..|.:.:.....:|....:||:.:.....::..|:
Zfish   454 ARFFIVRHVDFGSLGRMAMLALMVVFAAVIIQKYF 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh-III	NP_724562.2	ALDH_F3AB	72..515	CDD:143450	223/442 (50%)
aldh3a2b	NP_001315147.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	442	1.000	Domainoid score	I516
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	457	1.000	Inparanoid score	I1556
OMA	1	1.010	-	-		QHG62894
OrthoDB	1	1.010	-	-		D225045at33208
OrthoFinder	1	1.000	-	-		FOG0000656
OrthoInspector	1	1.000	-	-		otm25475
orthoMCL	1	0.900	-	-		OOG6_100557
Panther	1	1.100	-	-	O	PTHR43570
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2145
SonicParanoid	1	1.000	-	-		X395
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.910