DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh-III and P5CDh1

DIOPT Version :9

Sequence 1:	NP_724562.2	Gene:	Aldh-III / 45398	FlyBaseID:	FBgn0010548	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001189159.1	Gene:	P5CDh1 / 40434	FlyBaseID:	FBgn0037138	Length:	574	Species:	Drosophila melanogaster

Alignment Length:	480	Identity:	116/480 - (24%)
Similarity:	193/480 - (40%)	Gaps:	78/480 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 QQQQPE---QLQSESESDRMANF---DDTLQRARLAFSSGKTRNVSFRRKQLENLLRCYEEHENE 109
            :.:.||   |:.......::|:|   |..|  ...|..:.......:.|..:.:.|:.:|:..:.
  Fly    81 EYKTPEVRYQVMPHDHQHKLASFYYADKKL--IEKAIKTAVETQPKWDRVSIADRLKIWEKAADL 143

  Fly   110 IISALEADLRRPK---QESLIVETEF-----MKNDIRHILFQLDEWVQSEKPPKSFVNMMDDVQI 166
            :.:....||....   |....::.|.     :.:.||...:.|.| |...:|....:.:..:...
  Fly   144 MATTYRQDLNAATMLGQSKTAIQAEIDSAAELIDFIRMNAYFLKE-VTKYQPISENIKVTKNSLR 207

  Fly   167 YNDPFGVVLVIGAWNYPL---QLLLVPVASAIAAGNCVVIKPSEIA--ANCAKF-------IADV 219
            |....|.:..:..:|:..   .|...|.    ..||.|:.|||:.|  :|...|       :.|.
  Fly   208 YRGIDGFIAAVSPFNFTAIGGNLSYTPA----LMGNGVLWKPSDTAMLSNWIIFKIMREAGVPDG 268

  Fly   220 IPKYLDNDCYPVVCGGPSETAELLNQRFDYIFYTGS----TRVGKIIHAAANKYLT--PTTLELG 278
            :..::..| .||.  |.:.||   :.....|.:|||    .|:.|.:....:.|:.  ..|.|.|
  Fly   269 VVNFVPAD-GPVF--GDTITA---SPHLAGINFTGSVPTFNRLWKQVGNNIDNYVNFPRLTGECG 327

  Fly   279 GKSPCYIDKSVDMRTAVKRILWGKLINCGQTCIAPDYILCSK---------EVQEKFIVEAKDVL 334
            ||:..:|..|.|:.:.|...:......|||.|.|     ||:         :::|..:.||   .
  Fly   328 GKNFHFIHASADVESVVTSTIRSAFEYCGQKCSA-----CSRMYVPESLWPQIKEGLVCEA---A 384

  Fly   335 KEWYGENIQSSPDLSRVINANNFQRLLGLMKSGR------VAVGGNY-DASERFIEPTILVDVKE 392
            |...|:....|...|.||:...|:|:.|.::..:      :..||.| |:...|:.|||::....
  Fly   385 KLKIGDVQDFSSFTSAVIDDKAFKRITGYIEHAKKSPNLEILAGGTYSDSKGYFVNPTIVLSKDP 449

  Fly   393 TDPIMEEEIFGPILPIFNVESA--YDAIKFINAREK-PLVIYVFSNSNKLVK----EFRRSTTSG 450
            .|.||.||||||:|.|:..:.:  .:.:|.::...| .|...||......||    ||:.:  :|
  Fly   450 KDRIMTEEIFGPVLSIYVYKESDLLETMKLVHTSTKFALTGAVFGQDEDFVKCALQEFKMA--AG 512

  Fly   451 GFSSNETIMHCGVDVLPFGGVGMSG 475
            .|..|:......|...||||..|||
  Fly   513 NFYINDKSTGSVVGQQPFGGGRMSG 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh-III	NP_724562.2	ALDH_F3AB	72..515	CDD:143450	110/453 (24%)
P5CDh1	NP_001189159.1	ALDH_F4-17_P5CDH	41..563	CDD:143441	116/480 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454112
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830