DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh-III and Aldh16a1

DIOPT Version :9

Sequence 1:	NP_724562.2	Gene:	Aldh-III / 45398	FlyBaseID:	FBgn0010548	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001028878.1	Gene:	Aldh16a1 / 361571	RGDID:	1566295	Length:	802	Species:	Rattus norvegicus

Alignment Length:	297	Identity:	66/297 - (22%)
Similarity:	110/297 - (37%)	Gaps:	46/297 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 EPEPETESPIGIFT----SQPESQQQQPEQLQSESESDRMA-----NFDDTLQRARLAFSSGKTR 87
            |..|....|.|:|.    ..|.:|..:|.:..|...|..:|     :....::.|..|......:
  Rat   519 ETGPSPAPPYGLFVRGRFQSPGTQSSRPIKDSSGKVSSYVAEGGAKDIRGAVEAAHQAAPGWGAQ 583

  Fly    88 NVSFRRKQLENLLRCYEEHENEIISALEADLRRPKQESLIVETEFMKNDIRHILFQLDEW---VQ 149
            :...|...|..|....|..:    ..|.|.|.|......:.||| ::..:|    :|..|   ||
  Rat   584 SPRARASLLWALAAALERRK----QVLAAQLERHGAAPTVAETE-VELSVR----RLQTWATRVQ 639

  Fly   150 SEKPPKSFVNMMDDVQIYNDPFGVVLVIGAWNYPLQLLLVPVASAIAAGNCVVIKPSE----IAA 210
            .:........:...|....:|.||:.|:....:|:...:..:|.|:|.||.||:.||.    :|.
  Rat   640 DQGQTLQVTGLRGPVLRLREPLGVLAVVCPDEWPMLAFVSLLAPALAHGNAVVLVPSGSCPLLAL 704

  Fly   211 NCAKFIADVIPKYLDNDCYPVVCGGPSETAE--LLNQRFDYIFYTGSTRVGKIIHAAANKYLTPT 273
            ...:.||.:.|..|.|    ||.|.......  .|:|....::|.||.:..:.:..|:...|.|.
  Rat   705 EACQDIAALFPAGLVN----VVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPV 765

  Fly   274 ----------TLELGGKSPCYIDKSVDMRTAVKRILW 300
                      .:|:.|.     ::.:.:..|..:.||
  Rat   766 WVNRDFPRAWDVEVQGS-----EQELSLHAARTKALW 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh-III	NP_724562.2	ALDH_F3AB	72..515	CDD:143450	55/248 (22%)
Aldh16a1	NP_001028878.1	ALDH-SF	19..491	CDD:416387
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..554		9/34 (26%)
		ALDH-SF	550..>765	CDD:416387	52/227 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900