DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh-III and CG8665

DIOPT Version :9

Sequence 1:	NP_724562.2	Gene:	Aldh-III / 45398	FlyBaseID:	FBgn0010548	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_610107.1	Gene:	CG8665 / 35407	FlyBaseID:	FBgn0032945	Length:	913	Species:	Drosophila melanogaster

Alignment Length:	471	Identity:	128/471 - (27%)
Similarity:	194/471 - (41%)	Gaps:	80/471 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 DDTLQRARLAFSSGKTRNVSFR-RKQLE-NLLRCYEEHENEIISALEADLRRPKQESLIVETEFM 133
            |..::.|..|| .|..|.::.| |.||. ||....|.::.|:.:....|       |..|.|..:
  Fly   473 DKAVRAAHSAF-YGSWRQITPRQRGQLMLNLADLMERNKEELATIESVD-------SGAVYTLAL 529

  Fly   134 KNDIRHILFQLDEWVQSEKPPKSFVNMMDDVQ-----------------IYNDPFGVVLVIGAWN 181
            |.   |:...::.|       :.|....|.:|                 ...:|.||..:|..||
  Fly   530 KT---HVGMSIEAW-------RYFAGWCDKIQGNTIPVNPARPNNVLTFTRKEPIGVCGLITPWN 584

  Fly   182 YPLQLLLVPVASAIAAGNCVVIKPSEIAANCAKFIADV-----IPKYLDNDCYPVVCGGPSETAE 241
            |||.:|...:|:.|||||..:|||::.....|...|::     .|..:.|    |:.|..|:..:
  Fly   585 YPLMMLSWKMAACIAAGNTCLIKPAQTCPLTALKFAELTVRAGFPPGVIN----VLPGKGSDAGQ 645

  Fly   242 LL--NQRFDYIFYTGSTRVGK-IIHAAANKYLTPTTLELGGKSPCYIDKSVDMRTAVKRILWGKL 303
            .:  ::....:.:||||.:|| |:.:.|:..|...:||||||||..|....||..|||..:....
  Fly   646 AVADHELVRKLGFTGSTPIGKHIMKSCADSNLKKCSLELGGKSPLIIFADCDMDKAVKHGMSSVF 710

  Fly   304 INCGQTCIAPDYILCSKEVQEKFIVEAKDVLKEWYGENIQSSPDLSRVINANN----FQRLL--- 361
            .|.|:.|||...:.....:.::||   :.|||:.....|....|.|......|    |.:||
  Fly   711 FNKGENCIAAGRLFVEDRIHDEFI---RRVLKDLRTMTIGDPLDRSTAHGPQNHKAHFDKLLEFC 772

  Fly   362 --GLMKSGRVAVGG-------NYDASERFIEPTILVDVKETDPIMEEEIFGPILPI--FNVESAY 415
              |:.:..::..||       .|     |..||:..:|.:...|.:||.||||:.|  ||.....
  Fly   773 RRGVDEGAKLVYGGCRVPNLKGY-----FFTPTVFTNVTDDMFIAQEESFGPIMIISKFNGSDID 832

  Fly   416 DAIKFINAREKPLVIYVFSNSNKLVKEFRRSTTSGGFSSNETIMHCGVDV-LPFGGVGMSGMGRY 479
            ..::..|..|..|...||:........|.....:|....|   ::...|| .||||...||.|:.
  Fly   833 SLMQRANRTEYGLASGVFTKDIGKALNFADRIEAGTVFVN---VYNKTDVAAPFGGFKQSGYGKD 894

  Fly   480 HGKYGFETFTHKKSCL 495
            .|:.....:. |..|:
  Fly   895 LGQEALNEYL-KTKCV 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh-III	NP_724562.2	ALDH_F3AB	72..515	CDD:143450	127/470 (27%)
CG8665	NP_610107.1	Fmt	4..315	CDD:223301
		FMT_core	5..207	CDD:294280
		FDH_Hydrolase_C	212..316	CDD:187731
		PP-binding	338..403	CDD:278949
		PLN02466	396..909	CDD:215259	127/469 (27%)
		ALDH_F1L_FTFDH	428..913	CDD:143458	128/471 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454123
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740