DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh-III and aldh3b1

DIOPT Version :9

Sequence 1:	NP_724562.2	Gene:	Aldh-III / 45398	FlyBaseID:	FBgn0010548	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_775328.2	Gene:	aldh3b1 / 282559	ZFINID:	ZDB-GENE-021120-3	Length:	473	Species:	Danio rerio

Alignment Length:	456	Identity:	215/456 - (47%)
Similarity:	302/456 - (66%)	Gaps:	11/456 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 LQRARLAFSSGKTRNVSFRRKQLENLLRCYEEHENEIISALEADLRRPKQESLIVETEFMKNDIR 138
            |:|.|.||.||.|..|.||..|||.::..:|::|.:|:.||..||.:||.|:::.|.:.:.|||.
Zfish     8 LERLRGAFRSGVTLPVHFRLTQLEAMMSLFEDNETQILEALHEDLAKPKFETVLSEIDIVVNDIC 72

  Fly   139 HILFQLDEWVQSEKPPKSFVNMMDDVQIYNDPFGVVLVIGAWNYPLQLLLVPVASAIAAGNCVVI 203
            :.:..|..|:|......:....:||..:..:|.||||:|||||||:||:|.|:..|||||||.::
Zfish    73 YNISNLQTWMQPSYVGTNLATKLDDCFVRREPLGVVLIIGAWNYPIQLILSPLIGAIAAGNCAIL 137

  Fly   204 KPSEIAANCAKFIADVIPKYLDNDCYPVVCGGPSETAELLNQRFDYIFYTGSTRVGKIIHAAANK 268
            |||||:....|.:|::|||||..:||.|||||..||..||..|||:||||||..|.:.:..||..
Zfish   138 KPSEISKATEKLLAELIPKYLSQECYAVVCGGAEETKTLLENRFDHIFYTGSQSVARCVLQAAAV 202

  Fly   269 YLTPTTLELGGKSPCYIDKSVDMRTAVKRILWGKLINCGQTCIAPDYILCSKEVQEKFIVEAKDV 333
            :|||.|||||||.||.|...:||:.|.||::|.|..|.||:|:||||:||:.||::..:...|:.
Zfish   203 HLTPVTLELGGKCPCLIYGRLDMKAAAKRLVWAKFFNSGQSCVAPDYVLCTDEVKDMLLPFMKEA 267

  Fly   334 LKEWYGENIQSSPDLSRVINANNFQRLLGLMK--SGRVAVGGNYDASERFIEPTILVDVKETDPI 396
            |:.:||...|.|||..|::...::.||:.|||  .|::.:||......|:|.||::||||.||.:
Zfish   268 LESFYGSEPQESPDYGRIVTDRHWDRLIELMKRSEGKIVIGGESVKETRYIAPTVIVDVKGTDAL 332

  Fly   397 MEEEIFGPILPIFNVESAYDAIKFINAREKPLVIYVFSNSNKLVKEFRRSTTSGGFSSNETIMHC 461
            |:||||||||||..::|..:.|.|||.:||.|.:|.||:.:::|......|:||||.||:.|:|.
Zfish   333 MQEEIFGPILPILTIKSLDEGINFINEKEKALALYAFSDESQVVTTVLERTSSGGFCSNDGIVHM 397

  Fly   462 GVDVLPFGGVGMSGMGRYHGKYGFETFTHKKSCL--GKDLSPLGEKLSSARYPPYSDRKGSLLSF 524
            .:..|||||||.||||..||::|||||:||:.|:  |..|    |:::..|||||::   |.||:
Zfish   398 TLPGLPFGGVGASGMGNCHGRWGFETFSHKRGCMLRGWGL----ERVNVLRYPPYTE---SNLSW 455

  Fly   525 L 525
            |
Zfish   456 L 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh-III	NP_724562.2	ALDH_F3AB	72..515	CDD:143450	210/444 (47%)
aldh3b1	NP_775328.2	ALDH_F3AB	5..449	CDD:143450	210/444 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589157
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H73890
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62894
OrthoDB	1	1.010	-	-		D225045at33208
OrthoFinder	1	1.000	-	-		FOG0000656
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100557
Panther	1	1.100	-	-	O	PTHR43570
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2145
SonicParanoid	1	1.000	-	-		X395
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.750