DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh-III and ALDH3A2

DIOPT Version :9

Sequence 1:	NP_724562.2	Gene:	Aldh-III / 45398	FlyBaseID:	FBgn0010548	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001026976.1	Gene:	ALDH3A2 / 224	HGNCID:	403	Length:	508	Species:	Homo sapiens

Alignment Length:	490	Identity:	242/490 - (49%)
Similarity:	323/490 - (65%)	Gaps:	18/490 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 LQRARLAFSSGKTRNVSFRRKQLENLLRCYEEHENEIISALEADLRRPK-----QESLIV--ETE 131
            ::|.|.||.||::|.:.||.:|||.|.|..:|.|.:|::|:.|||.:.:     ||.:.|  |.:
Human     5 VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEID 69

  Fly   132 FMKNDIRHILFQLDEWVQSEKPPKSFVNMMDDVQIYNDPFGVVLVIGAWNYPLQLLLVPVASAIA 196
            ||       |..|.|||.::...|:.:.|:|:..|...|.||||:|||||||..|.:.|:..|||
Human    70 FM-------LENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIA 127

  Fly   197 AGNCVVIKPSEIAANCAKFIADVIPKYLDNDCYPVVCGGPSETAELLNQRFDYIFYTGSTRVGKI 261
            |||.|:|||||::.|.||.:|.::|:|||.|.|.|:.||..||.|||.||||:|||||:|.||||
Human   128 AGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKI 192

  Fly   262 IHAAANKYLTPTTLELGGKSPCYIDKSVDMRTAVKRILWGKLINCGQTCIAPDYILCSKEVQEKF 326
            :..||.|:|||.||||||||||||||..|:....:||.|||.:||||||||||||||...:|.:.
Human   193 VMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQI 257

  Fly   327 IVEAKDVLKEWYGENIQSSPDLSRVINANNFQRLLGLMKSGRVAVGGNYDASERFIEPTILVDVK 391
            :.:.|:.:||:|||||:.|||..|:||..:|:|:|.|::..::|.||..|.:.|:|.||:|.||.
Human   258 VWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVD 322

  Fly   392 ETDPIMEEEIFGPILPIFNVESAYDAIKFINAREKPLVIYVFSNSNKLVKEFRRSTTSGGFSSNE 456
            ....:|:||||||||||..|::..:||.|||.|||||.:||||:::||:|.....|:|||.:.|:
Human   323 PKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGND 387

  Fly   457 TIMHCGVDVLPFGGVGMSGMGRYHGKYGFETFTHKKSCLGKDLSPLGEKLSSARYPPYSDRKGSL 521
            .|||..::..||||||.||||.||||:.|:||:|::.||.|.|.  .|..:..||||.|..|...
Human   388 VIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLK--REGANKLRYPPNSQSKVDW 450

  Fly   522 LSFLLRKRRPLPNLHLSHVLAIGLGVGLTVLTNYY 556
            ..|.|.||.....|.|  :|...||:...||...|
Human   451 GKFFLLKRFNKEKLGL--LLLTFLGIVAAVLVKKY 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh-III	NP_724562.2	ALDH_F3AB	72..515	CDD:143450	228/447 (51%)
ALDH3A2	NP_001026976.1	ALDH_F3AB	5..444	CDD:143450	228/447 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	456	1.000	Domainoid score	I495
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1337
OMA	1	1.010	-	-		QHG62894
OrthoDB	1	1.010	-	-		D225045at33208
OrthoFinder	1	1.000	-	-		FOG0000656
OrthoInspector	1	1.000	-	-		otm51485
orthoMCL	1	0.900	-	-		OOG6_100557
Panther	1	1.100	-	-	O	PTHR43570
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2145
SonicParanoid	1	1.000	-	-		X395
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.810