Protein Alignment Aldh-III and ALDH9A1

DIOPT Version :10

• Sequence 1: NP_724562.2
• Gene: Aldh-III / 45398
• FlyBaseID: FBgn0010548
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_000687.3
• Gene: ALDH9A1 / 223
• HGNCID: 412
• Length: 518
• Species: Homo sapiens
• Alignment Length: 550
• Identity: 145/550 - (26%)
• Similarity: 219/550 - (39%)
• Gaps: 120/550 - (21%)

  Fly     5 AIKPHPEAN--------GAPINAAGDRPITTVINIEP----------EPETESPIGIFTSQPESQ 51
            :::|.|.|.        ..|:|..|.      ..:||          ||.|...|..||...|.:
Human    16 SLRPSPVAAMSTGTFVVSQPLNYRGG------ARVEPADASGTEKAFEPATGRVIATFTCSGEKE 74

  Fly    52 QQQPEQLQSESESDRMANFDDTLQRARLAFSSGKTRNVSFRRKQLENLLRCYEEHENEII----- 111
                            .|.  .:|.|:.||.....::...|.:.|....|...|.|:||.
Human    75 ----------------VNL--AVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECI 121

  Fly   112 ----SALEADLRRPKQESLIVETEFMKNDIRHILFQLDEWVQS----------EKPPKSFVNMMD 162
                |..||.|                 || .|.:|..|:...          :.|..||
Human   122 NNGKSIFEARL-----------------DI-DISWQCLEYYAGLAASMAGEHIQLPGGSF----- 163

  Fly   163 DVQIYNDPFGVVLVIGAWNYPLQLLLVPVASAIAAGNCVVIKPSEIAANCAKFIADV-----IPK 222
             .....:|.||.:.|||||||.|:.....|.|:|.||.:|.|||......|..:|::     :|.
Human   164 -GYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPP 227

  Fly   223 YLDNDCYPVVCGGPSETAELLNQRFDY--IFYTGSTRVGKIIHAAANKYLTPTTLELGGKSPCYI 285
            .|.|    ||.|| :.|.:.|.|..|.  :.:|||...|..|...:.|.:.|.|||||||||..|
Human   228 GLFN----VVQGG-AATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLII 287

  Fly   286 DKSVDMRTAVKRILWGKLINCGQTCIAPDYILCSKEVQEKFIVE-AKDVLKEWYGENIQSSPDLS 349
            ....||..|||..|....:..||.|.....:...||:.:||..| .|...:...|:.:.....:.
Human   288 FSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMG 352

  Fly   350 RVINANNFQRLLGLMK-----SGRVAVGGNYDASE-------RFIEPTILVDVKETDPIMEEEIF 402
            .:||..:.:|:||.:|     ..:|..||:....|       .::.|.:|.:.::....::||||
Human   353 PLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIF 417

  Fly   403 GPILPIFNVESAYDAIKFINAREKPLVIYVFS----NSNKLVKEFRRSTTSGGFSSNETIMHCGV 463
            ||::.|.:.::..:.::..|.....|...||:    .::::|.|.:..|.   |.:|..:...
Human   418 GPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTC---FINNYNVSPV-- 477

  Fly   464 DVLPFGGVGMSGMGRYHGKYGFETFTHKKS 493
             .|||||...||.||.:|:...|.::..|:
Human   478 -ELPFGGYKKSGFGRENGRVTIEYYSQLKT 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Aldh-III	NP_724562.2	ALDH_F3AB	72..515	CDD:143450	129/464 (28%)
ALDH9A1	NP_000687.3	ALDH_F9_TMBADH	55..512	CDD:143409	137/504 (27%)