Protein Alignment Aldh-III and ALDH1B1

DIOPT Version :10

• Sequence 1: NP_724562.2
• Gene: Aldh-III / 45398
• FlyBaseID: FBgn0010548
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_011516104.2
• Gene: ALDH1B1 / 219
• HGNCID: 407
• Length: 564
• Species: Homo sapiens
• Alignment Length: 458
• Identity: 132/458 - (28%)
• Similarity: 206/458 - (44%)
• Gaps: 45/458 - (9%)

  Fly    62 SESDRMANFDDTLQRARLAFSSGK--TRNVSFRRKQLENLLRCYEEHENEIISALEA-DLRRPKQ 123
            :|.|| |:.|..::.||.||..|.  .|..:..|.:|.|.|....|.:...:::||. |..:|.|
Human   116 AEGDR-ADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLASLETLDNGKPFQ 179

  Fly   124 ESLIVETEFMKNDIRHILFQLDEWVQSEKPPKSFVNMMDDVQI---YNDPFGVVLVIGAWNYPLQ 185
            ||..::.:.:....|:.....|:|.....|       ||....   .::|.||...|..||:||.
Human   180 ESYALDLDEVIKVYRYFAGWADKWHGKTIP-------MDGQHFCFTRHEPVGVCGQIIPWNFPLV 237

  Fly   186 LLLVPVASAIAAGNCVVIKPSEIAANCAKFIADVI-----PKYLDNDCYPVVCG-GPSETAELLN 244
            :....:|.|:|.||.||:|.:|.....|.::|.:|     |..:.|    ::.| ||:..|.:..
Human   238 MQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVN----IITGYGPTAGAAIAQ 298

  Fly   245 Q-RFDYIFYTGSTRVGKIIH-AAANKYLTPTTLELGGKSPCYIDKSVDMRTAVKRILWGKLINCG 307
            . ..|.:.:||||.||.:|. ||.:..|...|||||||||..:....||..||::.......|.|
Human   299 HVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMG 363

  Fly   308 QTCIAPDYILCSKEVQEKFIVEAKDVLKEW-----YGENIQSSPDLSRVINANNFQRLLGLM--- 364
            |.|.|.......:.:..:|:....:..|:.     :..:.|..|.    ::...|:|:||.:
Human   364 QCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGPQ----VDKEQFERVLGYIQLG 424

  Fly   365 -KSGRVAVGGNYDASER--FIEPTILVDVKETDPIMEEEIFGPILPIFNVESAYDAIKFINAREK 426
             |.|...:.|.....||  ||:||:...|::...|.:||||||:.|:|..:...:.::..|....
Human   425 QKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVERANNTRY 489

  Fly   427 PLVIYVFSNSNKLVKEFRRSTTSGGFSSNE-TIMHCGVDVLPFGGVGMSGMGRYHGKYGFETFTH 490
            .|...||:........|.::..:|....|. .|:.|..   ||||...||.||..|:.|.:.:|.
Human   490 GLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHT---PFGGFKESGNGRELGEDGLKAYTE 551

  Fly   491 KKS 493
            .|:
Human   552 VKT 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Aldh-III	NP_724562.2	ALDH_F3AB	72..515	CDD:143450	127/448 (28%)
ALDH1B1	XP_011516104.2	ALDH_F1AB_F2_RALDH1	78..558	CDD:143459	132/458 (29%)