Protein Alignment Aldh-III and ALDH2

DIOPT Version :9

• Sequence 1: NP_724562.2
• Gene: Aldh-III / 45398
• FlyBaseID: FBgn0010548
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_000681.2
• Gene: ALDH2 / 217
• HGNCID: 404
• Length: 517
• Species: Homo sapiens
• Alignment Length: 461
• Identity: 131/461 - (28%)
• Similarity: 219/461 - (47%)
• Gaps: 51/461 - (11%)

  Fly    62 SESDRMANFDDTLQRARLAFSSGK--TRNVSFRRKQLENLLRCYEEHENEIISALEA-DLRRPKQ 123
            :|.|: .:.|..::.||.||..|.  .|..:..|.:|.|.|....|.:...::|||. |..:|..
Human    69 AEGDK-EDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYV 132

  Fly   124 ESLIVETEFMKNDIRHILFQLDEWVQSEKPPKSFVNMMDDVQIY--NDPFGVVLVIGAWNYPLQL 186
            .|.:|:.:.:...:|:.....|::.....|      :..|...|  ::|.||...|..||:||.:
Human   133 ISYLVDLDMVLKCLRYYAGWADKYHGKTIP------IDGDFFSYTRHEPVGVCGQIIPWNFPLLM 191

  Fly   187 LLVPVASAIAAGNCVVIKPSEIAANCAKFIADVI-----PKYLDNDCYPVVCG-GPSETAELL-N 244
            ....:..|:|.||.||:|.:|.....|.::|::|     |..:.|    :|.| ||:..|.:. :
Human   192 QAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVN----IVPGFGPTAGAAIASH 252

  Fly   245 QRFDYIFYTGSTRVGKIIH-AAANKYLTPTTLELGGKSPCYIDKSVDMRTAVKRILWGKLINCGQ 308
            :..|.:.:||||.:|::|. ||.:..|...|||||||||..|....||..||::..:....|.||
Human   253 EDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQ 317

  Fly   309 TCIAPDYILCSKEVQEKF----IVEAKDVLKEWYGENIQSSPDLSRVINANNFQRLLGLMKSG-- 367
            .|.|.......:::.::|    :..||..:   .|....|..:....::...|:::||.:.:|
Human   318 CCCAGSRTFVQEDIYDEFVERSVARAKSRV---VGNPFDSKTEQGPQVDETQFKKILGYINTGKQ 379

  Fly   368 ---RVAVGGNYDASER--FIEPTILVDVKETDPIMEEEIFGPILPIFNVESAYDAIKFINAREKP 427
               ::..||.. |::|  ||:||:..||::...|.:||||||::.|...::..:.:...|.....
Human   380 EGAKLLCGGGI-AADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYG 443

  Fly   428 LVIYVFSNSNKLVKEFRRST-TSGGFSSNETIMHCGVDVL----PFGGVGMSGMGRYHGKYGFET 487
            |...||:      |:..::. .|....:....::| .||.    ||||..|||.||..|:||.:.
Human   444 LAAAVFT------KDLDKANYLSQALQAGTVWVNC-YDVFGAQSPFGGYKMSGSGRELGEYGLQA 501

  Fly   488 FTHKKS 493
            :|..|:
Human   502 YTEVKT 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Aldh-III	NP_724562.2	ALDH_F3AB	72..515	CDD:143450	128/451 (28%)
ALDH2	NP_000681.2	ALDH_F1AB_F2_RALDH1	31..511	CDD:143459	131/461 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810