DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh-III and Aldh1l2

DIOPT Version :9

Sequence 1:	NP_724562.2	Gene:	Aldh-III / 45398	FlyBaseID:	FBgn0010548	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_705771.2	Gene:	Aldh1l2 / 216188	MGIID:	2444680	Length:	923	Species:	Mus musculus

Alignment Length:	469	Identity:	123/469 - (26%)
Similarity:	208/469 - (44%)	Gaps:	71/469 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 MANFDDTLQRARLAFSSGK--TRNVSFRRKQLENLLRCYEEHENEIISALEADLRRPKQESLIVE 129
            :|:.|..:..|:.||.:|:  ..|...|.:.:..|....||::.| ::.:||      .:|..|.
Mouse   479 LADVDRAVAAAKDAFENGEWGRMNARDRGRLMYRLADLMEENQEE-LATIEA------LDSGAVY 536

  Fly   130 TEFMKNDIRHILFQLDEWVQSEKPPKSFVNMMDDVQ-----------IYN------DPFGVVLVI 177
            |..:|.   ||...:..:       :.|....|.:|           .||      :|.|...:|
Mouse   537 TLALKT---HIGMSVQTF-------RYFAGWCDKIQGSTIPINQARPNYNLTFTKKEPLGACAII 591

  Fly   178 GAWNYPLQLLLVPVASAIAAGNCVVIKPSEIAANCAKFIADV-----IPKYLDNDCYPVVCGGPS 237
            ..|||||.:|....|:.:||||.:|:||:::....|...|::     .||.:.|    ::.|...
Mouse   592 IPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELTVKAGFPKGVIN----IIPGSGG 652

  Fly   238 ETAELLNQRFDY--IFYTGSTRVGK-IIHAAANKYLTPTTLELGGKSPCYIDKSVDMRTAVKRIL 299
            ...:.|:|..|.  :.:||||.||| |:.:.|...|...:||||||||..|....|:..||:..:
Mouse   653 VAGQRLSQHPDIRKLGFTGSTSVGKQIMKSCAVSNLKKVSLELGGKSPLIIFSDCDLEKAVRMGM 717

  Fly   300 WGKLINCGQTCIAPDYILCSKEVQEKFIVEAKDVLKEW-YGENIQSSPDLSRVINANNFQRLL-- 361
            .....|.|:.|||...:...:.:.::|:....:.:|:. .|:.:..|.|.....:..:.::||
Mouse   718 GAVFFNKGENCIAAGRLFVEEAIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHRAHLEKLLQY 782

  Fly   362 ---GLMKSGRVAVGGNYDASER---FIEPTILVDVKETDPIMEEEIFGPILPIFNVESA-YDAI- 418
               |:.:...:..||.  ..:|   |:|||:...|::...:.:||.||||:.|...::. .|.:
Mouse   783 CETGVQEGATLVYGGR--QVQRPGFFMEPTVFTGVEDHMYLAKEESFGPIMVISKFQNGDIDGVL 845

  Fly   419 KFINAREKPLVIYVFS---NSNKLVKEFRRSTTSGGFSSNETIMHCGVDV-LPFGGVGMSGMGRY 479
            :..|..|..|...||:   |....|.:...:.|....:.|:|      || .||||:..||.|:.
Mouse   846 QRANNTEYGLASGVFTRDINKAMYVSDKLEAGTVFINTYNKT------DVAAPFGGMKQSGFGKD 904

  Fly   480 HGKYGFETFTHKKS 493
            .|:.....:...|:
Mouse   905 LGEEALNEYLKIKT 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh-III	NP_724562.2	ALDH_F3AB	72..515	CDD:143450	121/464 (26%)
Aldh1l2	NP_705771.2	Fmt	22..326	CDD:223301
		FMT_core_FDH_N	23..225	CDD:187716
		GART	23..225
		FDH_Hydrolase_C	228..327	CDD:187731
		PP-binding	346..410	CDD:278949
		ALDH_F1L_FTFDH	438..923	CDD:143458	123/469 (26%)
		Aldehyde dehydrogenase	438..923		123/469 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900