Protein Alignment Aldh-III and ALDH1A1

DIOPT Version :9

• Sequence 1: NP_724562.2
• Gene: Aldh-III / 45398
• FlyBaseID: FBgn0010548
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_000680.2
• Gene: ALDH1A1 / 216
• HGNCID: 402
• Length: 501
• Species: Homo sapiens
• Alignment Length: 484
• Identity: 135/484 - (27%)
• Similarity: 209/484 - (43%)
• Gaps: 85/484 - (17%)

  Fly    56 EQLQSESESDRMANFDDTLQRARLAFSSG---KTRNVSFRRKQLENLLRCYEEHENEIISALEAD 117
            |:|....|.|: .:.|..::.||.||..|   :|.:.|.|.:.|..|                ||
Human    47 EELCQVEEGDK-EDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKL----------------AD 94

  Fly   118 LRRPKQESLIVETEFMKNDIRHILFQLDEWVQSEKPPKSFVNMMDDVQ-------------IYND 169
            |.. :...|:...|.|.....:....|::.....|..:......|.:|             ..::
Human    95 LIE-RDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHE 158

  Fly   170 PFGVVLVIGAWNYPLQLLLVPVASAIAAGNCVVIKPSE----IAANCAKFI---------ADVIP 221
            |.||...|..||:||.:|:..:..|::.||.||:||:|    .|.:.|..|         .:::|
Human   159 PIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVP 223

  Fly   222 KYLDNDCYPVVCGGPSETAELLNQR-FDYIFYTGSTRVGKIIHAAANK-YLTPTTLELGGKSPCY 284
            .|           ||:..|.:.:.. .|.:.:||||.|||:|..||.| .|...||||||||||.
Human   224 GY-----------GPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCI 277

  Fly   285 IDKSVDMRTAVKRILWGKLINCGQTCIAPDYILCSKEVQEKFIVEAKDVLKEWYGEN-----IQS 344
            :....|:..||:....|...:.||.|||...|...:.:.::|:..:.:..|::...|     :..
Human   278 VLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQ 342

  Fly   345 SPDLSRVINANNFQRLLGLMKSGR------VAVGGNYDASERFIEPTILVDVKETDPIMEEEIFG 403
            .|.    |:...:.::|.|::||:      ...||.:.....|::||:..:|.:...|.:|||||
Human   343 GPQ----IDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFG 403

  Fly   404 PILPIFNVESAYDAIKFINAREKPLVIYVFSNS-NKLVKEFRRSTTSGGFSSNETIMHC-GV--D 464
            |:..|...:|..|.||..|.....|...||:.. :|.:      |.|....:....::| ||  .
Human   404 PVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAI------TISSALQAGTVWVNCYGVVSA 462

  Fly   465 VLPFGGVGMSGMGRYHGKYGFETFTHKKS 493
            ..||||..|||.||..|:|||..:|..|:
Human   463 QCPFGGFKMSGNGRELGEYGFHEYTEVKT 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Aldh-III	NP_724562.2	ALDH_F3AB	72..515	CDD:143450	130/468 (28%)
ALDH1A1	NP_000680.2	ALDH_F1AB_F2_RALDH1	15..495	CDD:143459	135/484 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810