DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh-III and alh-3

DIOPT Version :9

Sequence 1:	NP_724562.2	Gene:	Aldh-III / 45398	FlyBaseID:	FBgn0010548	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_502054.2	Gene:	alh-3 / 177999	WormBaseID:	WBGene00000109	Length:	908	Species:	Caenorhabditis elegans

Alignment Length:	535	Identity:	137/535 - (25%)
Similarity:	222/535 - (41%)	Gaps:	107/535 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PHPE-ANGAPINAAGDRPITTVINIEPEPETESPIGIFTSQPESQQQQPEQLQSESESDRMANFD 71
            ||.: .:|..:.::..|...|:     .|.||.||                  .|.....:|:.|
Worm   427 PHDQFIDGKFVGSSDGRTFKTI-----NPATEKPI------------------CELPLATVADVD 468

  Fly    72 DTLQRARLAFSSGKTRNVSFRR--KQLENLLRCYEEHENEI--ISALEADLRRPKQESLIVETEF 132
            ..::.|:.||..|:.|.:|.|.  |:|..|....|||:.|:  :.:|:|.         .|.|..
Worm   469 RAVRAAKKAFERGEWRQMSARERGKRLYKLAELMEEHKEELATLESLDAG---------AVYTLA 524

  Fly   133 MKNDIRHILFQLDEWVQSEKPPKSFVNMMDDVQ-----IYN------------DPFGVVLVIGAW 180
            :|.   |:...:|.|       :.|....|.:|     |.|            :|.|||.:|..|
Worm   525 LKT---HVGMSIDVW-------RYFAGWCDKIQGKTIPISNARPNKNLCLTLREPIGVVGLITPW 579

  Fly   181 NYPLQLLLVPVASAIAAGNCVVIKPSEIAANCAKFIADV-----IPKYLDNDCYPVVCGGPSETA 240
            ||||.:|...:|:.:||||.||.||:::....|...|::     ||..:.|    :|.|..|...
Worm   580 NYPLMMLSWKMAACLAAGNTVVHKPAQVTPLTALKFAELSVLAGIPPGVIN----IVTGSGSLVG 640

  Fly   241 ELLNQRFDY--IFYTGSTRVG-KIIHAAANKYLTPTTLELGGKSPCYIDKSVDMRTAVKRILWGK 302
            ..|....|.  |.:||||.:| .::.:.|...:...:||||||||..|....|:..|||:.....
Worm   641 NRLTAHPDVRKIGFTGSTEIGATVMESCAKSNIKKVSLELGGKSPLIIFADADLEKAVKQACGAV 705

  Fly   303 LINCGQTCIAPDYILCSKEVQEKFIVEAKDVLKEW-YGENIQSSPDLSRVINANNFQRLLGLMK- 365
            ..|.|:.|||...:..:|.:.:.|:.:..:..|:: .|:.:..|.......:..:..:|:..::
Worm   706 FFNKGENCIAAGRVFIAKSIHDDFVKKLVEEAKQYQIGDPLDRSTAHGPQNHLAHLNKLVEYVEK 770

  Fly   366 ----SGRVAVGG-NYDASERFIEPTILVDVKETDPIMEEEIFGPILPI--FNVESAYDAIKFINA 423
                ..:|.||| ..:....:..||||.::.:.:....||.||||:.:  |:.:...|.::..|.
Worm   771 AVAGGAKVEVGGKRLEREGLYFPPTILSNIDDENFAASEESFGPIMCVSSFDDDDIEDVLRRAND 835

  Fly   424 REKPLVIYVFSNSNKLVKEFRRSTTSGGFSSNETIMHCG---------VDV-LPFGGVGMSGMGR 478
            .|..|...||:..:.  |..|.:..          :|.|         .|| .||||...||.|:
Worm   836 TEFGLAAGVFTRDSS--KSLRVAEA----------LHAGTVFVNTYQKTDVAAPFGGFKQSGFGK 888

  Fly   479 YHGKYGFETFTHKKS 493
            ..|:.....:...|:
Worm   889 DMGEEALNEYLVTKT 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh-III	NP_724562.2	ALDH_F3AB	72..515	CDD:143450	124/470 (26%)
alh-3	NP_502054.2	fmt	1..318	CDD:273088
		FMT_core_FDH_N	1..209	CDD:187716
		FDH_Hydrolase_C	214..315	CDD:187731
		PP-binding	335..393	CDD:278949
		ALDH-SF	423..908	CDD:299846	137/535 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810