Protein Alignment Aldh-III and ALDH1L2

DIOPT Version :10

• Sequence 1: NP_724562.2
• Gene: Aldh-III / 45398
• FlyBaseID: FBgn0010548
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001029345.2
• Gene: ALDH1L2 / 160428
• HGNCID: 26777
• Length: 923
• Species: Homo sapiens
• Alignment Length: 472
• Identity: 123/472 - (26%)
• Similarity: 213/472 - (45%)
• Gaps: 77/472 - (16%)

  Fly    67 MANFDDTLQRARLAFSSGKTRNVSFRRK-----QLENLLRCYEEHENEIISALEADLRRPKQESL 126
            :|:.|..:..|:.||.:|:...::.|.:     :|.:||   ||::.| ::.:||      .:|.
Human   479 LADVDKAVAAAKDAFENGEWGRMNARERGRLMYRLADLL---EENQEE-LATIEA------LDSG 533

  Fly   127 IVETEFMKNDIRHILFQLDEWVQSEKPPKSFVNMMDDVQ-----------------IYNDPFGVV 174
            .|.|..:|.   ||...:..:       :.|....|.:|                 ...:|.||.
Human   534 AVYTLALKT---HIGMSVQTF-------RYFAGWCDKIQGSTIPINQARPNRNLTFTKKEPLGVC 588

  Fly   175 LVIGAWNYPLQLLLVPVASAIAAGNCVVIKPSEIAANCAKFIADV-----IPKYLDNDCYPVVCG 234
            .:|..|||||.:|....|:.:||||.:|:||:::....|...|::     .||.:.|    ::.|
Human   589 AIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAGFPKGVIN----IIPG 649

  Fly   235 GPSETAELLNQRFDY--IFYTGSTRVGK-IIHAAANKYLTPTTLELGGKSPCYIDKSVDMRTAVK 296
            ......:.|::..|.  :.:||||.:|| |:.:.|...|...:||||||||..|....::..||:
Human   650 SGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGKSPLIIFNDCELDKAVR 714

  Fly   297 RILWGKLINCGQTCIAPDYILCSKEVQEKFIVEAKDVLKEW-YGENIQSSPDLSRVINANNFQRL 360
            ..:.....|.|:.|||...:...:.:.::|:....:.:|:. .|:.:..|.|.....:..:.::|
Human   715 MGMGAVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKL 779

  Fly   361 L-----GLMKSGRVAVGGNYDASER---FIEPTILVDVKETDPIMEEEIFGPILPIFNVESA-YD 416
            |     |:.:...:..||.  ..:|   |:|||:..||::...:.:||.||||:.|...::. .|
Human   780 LQYCETGVKEGATLVYGGR--QVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDID 842

  Fly   417 AI-KFINAREKPLVIYVFS---NSNKLVKEFRRSTTSGGFSSNETIMHCGVDV-LPFGGVGMSGM 476
            .: :..|:.|..|...||:   |....|.|...:.|....:.|:|      || .|||||..||.
Human   843 GVLQRANSTEYGLASGVFTRDINKAMYVSEKLEAGTVFINTYNKT------DVAAPFGGVKQSGF 901

  Fly   477 GRYHGKYGFETFTHKKS 493
            |:..|:.....:...|:
Human   902 GKDLGEEALNEYLKTKT 918

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Aldh-III	NP_724562.2	ALDH_F3AB	72..515	CDD:143450	121/467 (26%)
ALDH1L2	NP_001029345.2	Hydrolase domain. /evidence=ECO:0000250|UniProtKB:P28037	23..331
		FMT_core_FDH_N	23..225	CDD:187716
		FDH_Hydrolase_C	228..327	CDD:187731
		PP-binding	346..>390	CDD:425746
		Aldehyde dehydrogenase domain. /evidence=ECO:0000250|UniProtKB:P28037	438..923		123/472 (26%)
		ALDH_F1L_FTFDH	439..923	CDD:143458	123/472 (26%)