Protein Alignment Aldh-III and ALDH16A1

DIOPT Version :10

• Sequence 1: NP_724562.2
• Gene: Aldh-III / 45398
• FlyBaseID: FBgn0010548
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_699160.2
• Gene: ALDH16A1 / 126133
• HGNCID: 28114
• Length: 802
• Species: Homo sapiens
• Alignment Length: 616
• Identity: 116/616 - (18%)
• Similarity: 213/616 - (34%)
• Gaps: 173/616 - (28%)

  Fly    23 RPITTVINIEPEPET-----------ESPIGIFTS----QPESQQQQPEQ-----------LQSE 61
            |.|.|.:...|.||:           :..:|.:.:    :||.:...|.|           ||::
Human    11 REIFTSLEYGPVPESHACALAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQDPITGENLASCLQAQ 75

  Fly    62 SESDRMANFDDTLQRARLAFSSGKTRNVSFRRKQLENLLRCYEEHENEIISALEADLRRPKQESL 126
            :|....|     ::.||:||..........|.:.|..|....::|:..:.:.          |||
Human    76 AEDVAAA-----VEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLWTL----------ESL 125

  Fly   127 I---VETEFMKNDIRHILFQLDEW--VQSEKPPKSFVNMMDDVQIYNDPFGVVLVIGAWNYPLQL 186
            :   ...|....|:: :..||..:  :|:....::....        :|.||:.:|....:....
Human   126 VTGRAVREVRDGDVQ-LAQQLLHYHAIQASTQEEALAGW--------EPMGVIGLILPPTFSFLE 181

  Fly   187 LLVPVASAIAAGNCVVIKPSEIAANCAKFIADV------IPKYLDNDCYPVVCGGPSETAELLNQ 245
            ::..:..|:|.| |.|:.....|:.....:|.:      .|..|:      |..||:....:|..
Human   182 MMWRICPALAVG-CTVVALVPPASPAPLLLAQLAGELGPFPGILN------VLSGPASLVPILAS 239

  Fly   246 R--FDYIFYTGSTRVGKIIHAAANKYLTPTTLELGGKSPCYIDKSVDMRTAVKRIL---WGKLIN 305
            :  ...:.:.|:...|:.:..:.........|.||.:|...:..:.|:.:||:.::   |.....
Human   240 QPGIRKVAFCGAPEEGRALRRSLAGECAELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGP 304

  Fly   306 CGQTCIAPDYILCSKEVQEKFIVEAKDVLKEWYGENIQSSPDLSRVIN--------ANNFQRLLG 362
            .|...:          :||....||...|:|..| .::|...|...::        .:..||.:.
Human   305 GGLRLL----------IQESVWDEAMRRLQERMG-RLRSGRGLDGAVDMGARGAAACDLVQRFVR 358

  Fly   363 LMKS--GRVAVGGNYDASERFIEPTILVDVKETDPIMEEEIFGPILPIFNVESAYDAIKFINARE 425
            ..:|  .:|...|:..:...|..||::.::....|..:.|:..|::.         |..|..|:|
Human   359 EAQSQGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVV---------ASPFRTAKE 414

  Fly   426 KPLVIYVFSNSNKLVKEFRRSTTSGGFSS--NETI-----MHCGVDV--------------LPFG 469
            ..||              ...|..||.:|  :|.:     :..|:.|              :|.|
Human   415 ALLV--------------ANGTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPSVPTG 465

  Fly   470 GVGMSGMGRYHGKYGFETFTH------KKSCLGKDLS------------PLGEKLSSARYPPYS- 515
            |...||...:.|..|...:..      :.|||.|:|:            |.|.::..:..|||.
Human   466 GCKESGCSWHGGPDGLYEYLRPSGTPARLSCLSKNLNYDTFGLAVPSTLPAGPEIGPSPAPPYGL 530

  Fly   516 ------DRKGSLLSFLLRKRRPL----PNLH 536
                  ...|:      |..||:    .|||
Human   531 FVGGRFQAPGA------RSSRPIRDSSGNLH 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Aldh-III	NP_724562.2	ALDH_F3AB	72..515	CDD:143450	93/507 (18%)
ALDH16A1	NP_699160.2	ALDH-SF	19..492	CDD:448367	96/537 (18%)
		AdhE	525..>767	CDD:440636	10/37 (27%)