DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh-III and ALDH1L1

DIOPT Version :9

Sequence 1:	NP_724562.2	Gene:	Aldh-III / 45398	FlyBaseID:	FBgn0010548	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001257293.1	Gene:	ALDH1L1 / 10840	HGNCID:	3978	Length:	912	Species:	Homo sapiens

Alignment Length:	476	Identity:	133/476 - (27%)
Similarity:	206/476 - (43%)	Gaps:	83/476 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 RMANFDDTLQRARLAFSSGKTRNVSFRRK-----QLENLLRCYEEHENEI--ISALEADLRRPKQ 123
            ::.:.|..:..|:.||.:|:...:|.|.:     :|.:|:   |:|:.|:  |.||:|.
Human   467 QVTDVDKAVAAAKDAFENGRWGKISARDRGRLMYRLADLM---EQHQEELATIEALDAG------ 522

  Fly   124 ESLIVETEFMKNDIRHILFQLDEWVQSEKPPKSFVNMMDDVQ-----------------IYNDPF 171
               .|.|..:|.   |:...:..:       :.|....|.:|                 ...:|.
Human   523 ---AVYTLALKT---HVGMSIQTF-------RYFAGWCDKIQGSTIPINQARPNRNLTLTRKEPV 574

  Fly   172 GVVLVIGAWNYPLQLLLVPVASAIAAGNCVVIKPSEIAANCAKFIADV-----IPKYLDNDCYPV 231
            ||..:|..|||||.:|....|:.:||||.|||||:::....|...|::     |||.:.|    |
Human   575 GVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVN----V 635

  Fly   232 VCGGPSETAELLNQRFDY--IFYTGSTRVGK-IIHAAANKYLTPTTLELGGKSPCYIDKSVDMRT 293
            :.|..|...:.|:...|.  |.:||||.||| |:.:.|...:...:||||||||..|....|:..
Human   636 LPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCAISNVKKVSLELGGKSPLIIFADCDLNK 700

  Fly   294 AVKRILWGKLINCGQTCIAPDYILCSKEVQEKFIVE-AKDVLKEWYGENIQSSPDLSRVINANNF 357
            ||:..:.....|.|:.|||...:.....:.::|:.. .::|.|...|..:....|..   ..|:.
Human   701 AVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNPLDRDTDHG---PQNHH 762

  Fly   358 QRLLGLM-------KSGRVAV-GGN-YDASERFIEPTILVDVKETDPIMEEEIFGPILPIFN-VE 412
            ..|:.||       |.|...| ||| ......|.|||:..||::...|.:||.|||::.|.. .:
Human   763 AHLVKLMEYCQHGVKEGATLVCGGNQVPRPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFAD 827

  Fly   413 SAYDAI-KFINAREKPLVIYVFS---NSNKLVKEFRRSTTSGGFSSNETIMHCGVDV-LPFGGVG 472
            ...||: ...||.|..|...||:   |....|.:..::.|....:.|:|      || .||||..
Human   828 GDLDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFVNTYNKT------DVAAPFGGFK 886

  Fly   473 MSGMGRYHGKYGFETFTHKKS 493
            .||.|:..|:.....:...|:
Human   887 QSGFGKDLGEAALNEYLRVKT 907

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh-III	NP_724562.2	ALDH_F3AB	72..515	CDD:143450	132/470 (28%)
ALDH1L1	NP_001257293.1	Fmt	10..319	CDD:223301
		FMT_core_FDH_N	11..213	CDD:187716
		FDH_Hydrolase_C	216..316	CDD:187731
		PP-binding	335..401	CDD:278949
		ALDH_F1L_FTFDH	427..912	CDD:143458	133/476 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810